利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

23 条记录 (耗时 0.031 秒)

    Use of inhibitory oligonucleotides to treat autoimmune disease
    2.
    发明授权
    Use of inhibitory oligonucleotides to treat autoimmune disease 有权
    使用抑制性寡核苷酸治疗自身免疫性疾病

    公开(公告)号：US08729039B2

    公开(公告)日：2014-05-20

    申请号：US12862429

    申请日：2010-08-24

    申请人： Eyal Raz ,  Mark Roman

    发明人： Eyal Raz ,  Mark Roman

    IPC分类号： A61K31/70

    CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55561 ,  A61K2039/57 ,  C07K14/4703 ,  C12N15/117 ,  C12N2310/111 ,  C12N2310/17 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/33 ,  C12N2310/334 ,  C12N2310/3513 ,  C12Q1/6883 ,  Y02A50/41 ,  Y02A50/423

    摘要： The invention consists of oligonucleotides which inhibit the immunostimulatory activity of ISS-ODN (immunostimulatory sequence oligodeoxynucleotides) as well as methods for their identification and use. The oligonucleotides of the invention are useful in controlling therapeutically intended ISS-ODN adjuvant activity as well as undesired ISS-ODN activity exerted by recombinant expression vectors, such as those used for gene therapy and gene immunization. The oligonucleotides of the invention also have anti-inflammatory activity useful in reducing inflammation in response to infection of a host with ISS-ODN containing microbes, in controlling autoimmune disease and in boosting host Th2 type immune responses to an antigen. The invention also encompasses pharmaceutically useful conjugates of the oligonucleotides of the invention (including conjugate partners such as antigens and antibodies).

    摘要翻译： 本发明由抑制ISS-ODN（免疫刺激性寡脱氧核苷酸）的免疫刺激活性的寡核苷酸以及鉴定和使用的方法组成。 本发明的寡核苷酸可用于控制治疗性意图的ISS-ODN佐剂活性以及重组表达载体（例如用于基因治疗和基因免疫的那些）所产生的不期望的ISS-ODN活性。 本发明的寡核苷酸还具有抗炎活性，其可用于在控制具有含有ISS-ODN的微生物的宿主的感染中，在控制自身免疫疾病和促进对抗原的宿主Th2型免疫应答中减少炎症。 本发明还包括本发明的寡核苷酸的药学上有用的缀合物（包括缀合物如抗原和抗体）。

    Apparatus and methods for forming composite stiffeners and reinforcing structures
    6.
    发明授权
    Apparatus and methods for forming composite stiffeners and reinforcing structures 有权
    用于形成复合加强筋和加强结构的装置和方法

    公开(公告)号：US07513769B2

    公开(公告)日：2009-04-07

    申请号：US10903871

    申请日：2004-07-30

    申请人： Vernon M. Benson ,  Jason Slack ,  Todd A. Rosevear ,  James L. Harvey ,  Mark Roman ,  Timothy Olschewski

    发明人： Vernon M. Benson ,  Jason Slack ,  Todd A. Rosevear ,  James L. Harvey ,  Mark Roman ,  Timothy Olschewski

    IPC分类号： B28B3/12

    CPC分类号： B29C70/388 ,  B29C70/504 ,  B29C70/545 ,  B29K2307/00 ,  B29K2901/10 ,  B29L2031/003 ,  Y10T156/1002 ,  Y10T156/1028 ,  Y10T156/1031 ,  Y10T428/24124 ,  Y10T428/24628 ,  Y10T428/249948 ,  Y10T428/24995

    摘要： A method and apparatus are provided for forming elongated composite structural members with a desired cross-sectional geometry as taken transverse to the length of the member. An apparatus may include a base with a substantially elongated mandrel mounted thereon. One or more rollers configured to at least partially complementarily engage the mandrel are configured to roll over and press one or more plies of composite material onto the mandrel. The mandrel may be disposed on a rotary table and configured to exhibit a curved elongated geometry to form at least partially curved or arcuate elongated members. The present invention enables the formation of elongated structural members from resin impregnated materials while maintaining the materials in a substantially uncured state. The formed members may then be cocured with a skin or other composite structure.

    摘要翻译： 提供了一种用于形成细长复合结构构件的方法和装置，所述细长复合结构构件具有横向于构件长度的所需横截面几何形状。 设备可以包括其上安装有基本上细长的心轴的基座。 构造成至少部分地互补接合心轴的一个或多个辊构造成滚动并将一个或多个复合材料层压在心轴上。 心轴可以设置在旋转工作台上并且构造成呈现弯曲的细长几何形状以形成至少部分弯曲或弧形的细长构件。 本发明能够在将材料保持在基本上未固化状态的同时，从树脂浸渍材料形成细长的结构构件。 然后可以将形成的构件与皮肤或其它复合结构共同组合。

    Apparatus and methods for forming composite stiffeners and reinforcing structures
    8.
    发明申请
    Apparatus and methods for forming composite stiffeners and reinforcing structures 有权
    用于形成复合加强筋和加强结构的装置和方法

    公开(公告)号：US20050056362A1

    公开(公告)日：2005-03-17

    申请号：US10903871

    申请日：2004-07-30

    申请人： Vernon Benson ,  Jason Slack ,  Todd Rosevear ,  James Harvey ,  Mark Roman ,  Timothy Olschewski

    发明人： Vernon Benson ,  Jason Slack ,  Todd Rosevear ,  James Harvey ,  Mark Roman ,  Timothy Olschewski

    IPC分类号： B29C70/38 ,  B29C70/50 ,  B65H81/00

    CPC分类号： B29C70/388 ,  B29C70/504 ,  B29C70/545 ,  B29K2307/00 ,  B29K2901/10 ,  B29L2031/003 ,  Y10T156/1002 ,  Y10T156/1028 ,  Y10T156/1031 ,  Y10T428/24124 ,  Y10T428/24628 ,  Y10T428/249948 ,  Y10T428/24995

    摘要： A method and apparatus are provided for forming elongated composite structural members with a desired cross-sectional geometry as taken transverse to the length of the member. An apparatus may include a base with a substantially elongated mandrel mounted thereon. One or more rollers configured to at least partially complementarily engage the mandrel are configured to roll over and press one or more plies of composite material onto the mandrel. The mandrel may be disposed on a rotary table and configured to exhibit a curved elongated geometry to form at least partially curved or arcuate elongated members. The present invention enables the formation of elongated structural members from resin impregnated materials while maintaining the materials in a substantially uncured state. The formed members may then be cocured with a skin or other composite structure.

    摘要翻译： 提供了一种用于形成细长复合结构构件的方法和装置，所述细长复合结构构件具有横向于构件长度的所需横截面几何形状。 设备可以包括其上安装有基本上细长的心轴的基座。 构造成至少部分地互补接合心轴的一个或多个辊构造成滚动并将一个或多个复合材料层压在心轴上。 心轴可以设置在旋转工作台上并且构造成呈现弯曲的细长几何形状以形成至少部分弯曲或弧形的细长构件。 本发明能够在将材料保持在基本上未固化状态的同时，从树脂浸渍材料形成细长的结构构件。 然后可以将形成的构件与皮肤或其它复合结构共同组合。

    Inhibitors of DNA immunostimulatory sequence activity
    10.
    发明授权
    Inhibitors of DNA immunostimulatory sequence activity 失效
    抑制DNA的免疫刺激序列活性

    公开(公告)号：US06225292B1

    公开(公告)日：2001-05-01

    申请号：US09092314

    申请日：1998-06-05

    申请人： Eyal Raz ,  Mark Roman

    发明人： Eyal Raz ,  Mark Roman

    IPC分类号： A01N4304

    CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55561 ,  A61K2039/57 ,  C07K14/4703 ,  C12N15/117 ,  C12N2310/111 ,  C12N2310/17 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/33 ,  C12N2310/334 ,  C12N2310/3513 ,  C12Q1/6883 ,  Y02A50/41 ,  Y02A50/423

    摘要： The invention consists of oligonucleotides which inhibit the immunostimulatory activity of ISS-ODN (immunostimulatory sequence oligodeoxynucleotides) as well as methods for their identification and use. The oligonucleotides of the invention are useful in controlling therapeutically intended ISS-ODN adjuvant activity as well as undesired ISS-ODN activity exerted by recombinant expression vectors, such as those used for gene therapy and gene immunization. The oligonucleotides of the invention also have anti-inflammatory activity useful in reducing inflammation in response to infection of a host with ISS-ODN containing microbes, in controlling autoimmune disease and in boosting host Th2 type immune responses to an antigen. The invention also encompasses pharmaceutically useful conjugates of the oligonucleotides of the invention (including conjugate partners such as antigens and antibodies).

    摘要翻译： 本发明由抑制ISS-ODN（免疫刺激性寡脱氧核苷酸）的免疫刺激活性的寡核苷酸以及鉴定和使用的方法组成。 本发明的寡核苷酸可用于控制治疗性意图的ISS-ODN佐剂活性以及重组表达载体（例如用于基因治疗和基因免疫的那些）所产生的不期望的ISS-ODN活性。 本发明的寡核苷酸还具有抗炎活性，其可用于在控制具有含有ISS-ODN的微生物的宿主的感染中，在控制自身免疫疾病和促进对抗原的宿主Th2型免疫应答中减少炎症。 本发明还包括本发明的寡核苷酸的药学上有用的缀合物（包括缀合物如抗原和抗体）。