公开(公告)号：US20100143907A1

公开(公告)日：2010-06-10

申请号：US12514638

申请日：2006-11-13

Applicant: Kai Krohn ,  Wael Hassan ,  Päivi Peltomäki ,  Markku Helle ,  Sonja Hahtola ,  Annamari Ranki

Inventor： Kai Krohn ,  Wael Hassan ,  Päivi Peltomäki ,  Markku Helle ,  Sonja Hahtola ,  Annamari Ranki

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/156

Abstract: The present invention relates to the fields of genetics and oncology and provides methods for predicting and identifying tumors of epithelial origin. Specifically, the present invention relates to a novel method of predicting tumor initiation, tumor progression and/or carcinomas, the method comprising detecting genetic abnormality associated with tumors of epithelial origin. The present invention further relates to a novel method of identifying an individual with potential for developing carcinoma, the method comprising detection of genetic abnormalities. The present invention also relates to a method of predicting the progression of carcinomas and the transformation thereof to an aggressive variant, the method comprising detection of genetic abnormalities, which indicate the probability to develop carcinoma. The present invention also relates to a use of specific chromosomal region, a gene or a fragment thereof, and/or genetic markers for predicting tumor initiation, tumor progression and/or carcinoma. The present invention also relates to a use of specific chromosomal region or a gene or a fragment thereof in therapy, for the development of therapy, and for the preparation of a medicament for treating tumors of epithelial origin.

Abstract translation: 本发明涉及遗传学和肿瘤学领域，并提供预测和鉴定上皮起源肿瘤的方法。 具体地，本发明涉及一种预测肿瘤起始，肿瘤进展和/或癌的新方法，该方法包括检测与上皮起源的肿瘤相关的遗传异常。 本发明还涉及鉴定具有发展癌潜力的个体的新方法，所述方法包括检测遗传异常。 本发明还涉及预测癌的进展及其转化为侵略性变体的方法，所述方法包括检测遗传异常，其指示发生癌的可能性。 本发明还涉及特定染色体区域，其基因或其片段的用途和/或用于预测肿瘤起始，肿瘤进展和/或癌症的遗传标记。 本发明还涉及特异性染色体区域或其基因或片段在治疗中的用途，用于治疗的发展，以及用于制备治疗上皮肿瘤的药物。