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1.发明申请BIPHENYL COMPOUNDS FOR USE IN TREATING MALARIA AND OTHER PARASITIC DISORDERS 有权联苯胺化合物用于治疗疟疾和其他PARASITIC DISORDERS公开(公告)号：US20150274637A1
公开(公告)日：2015-10-01
申请号：US14343431
申请日：2012-09-10
IPC分类号： C07C69/616 , C07D213/30
CPC分类号： C07C69/616 , C07C69/734 , C07C257/06 , C07C257/14 , C07D213/30 , C07D295/205 , C07D311/80 , C07D319/08 , C07D321/10 , C07D321/12
摘要： The present invention relates to a compound of formula (I) as defined herein.
摘要翻译： 本发明涉及本文定义的式（I）化合物。
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2.发明授权公开(公告)号：US09499471B2
公开(公告)日：2016-11-22
申请号：US14343431
申请日：2012-09-10
IPC分类号： C07C69/616 , C07C257/06 , C07C257/14 , C07D311/80 , C07C69/734 , C07D321/10 , C07D321/12 , C07D295/205 , C07D213/30 , C07D319/08
CPC分类号： C07C69/616 , C07C69/734 , C07C257/06 , C07C257/14 , C07D213/30 , C07D295/205 , C07D311/80 , C07D319/08 , C07D321/10 , C07D321/12
摘要： The present invention relates to a compound of formula (I) as defined herein.
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3.发明授权Method for producing intermediates for the production of macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof 有权用于生产作为p27蛋白酶体降解的抑制剂的大环化合物的中间体的方法，例如铁蛋白及其衍生物公开(公告)号：US08853249B2
公开(公告)日：2014-10-07
申请号：US13513128
申请日：2010-12-14
申请人： Markus Kalesse , Ulrike Eggert
发明人： Markus Kalesse , Ulrike Eggert
IPC分类号： A61K31/429 , C07D513/08 , C07D209/20 , C07B53/00
CPC分类号： C07B53/00 , C07D209/20 , C07D513/08
摘要： The present invention relates to an improved method for the synthesis of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof.
摘要翻译： 本发明涉及一种用于合成特异性大环化合物的改进方法，其是p27蛋白酶体降解抑制剂，特别是金属蛋白酶及其衍生物。
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4.发明申请Method For Producing Intermediates For The Production Of Macrocycles That Are Inhibitors Of The Proteasomic Degradation of P27, Such As Argyrin And Derivatives Thereof 有权生产中间体的方法，用于生产大环内酯类的抑制剂，如P27的蛋白酶体降解，如Argyrin及其衍生物公开(公告)号：US20120295941A1
公开(公告)日：2012-11-22
申请号：US13513128
申请日：2010-12-14
申请人： Markus Kalesse , Ulrike Eggert
发明人： Markus Kalesse , Ulrike Eggert
IPC分类号： C07D513/08 , A61K31/429 , C07D209/20
CPC分类号： C07B53/00 , C07D209/20 , C07D513/08
摘要： The present invention relates to an improved method for the synthesis of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof.
摘要翻译： 本发明涉及一种用于合成特异性大环化合物的改进方法，其是p27蛋白酶体降解抑制剂，特别是金属蛋白酶及其衍生物。
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5.发明授权Method for producing intermediates for the production of novel macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof, and uses of said macrocycles 有权用于生产作为p27蛋白酶体降解的抑制剂的新型大环化合物的中间体的方法，例如金属蛋白和其衍生物，以及所述大环化合物的用途公开(公告)号：US09458200B2
公开(公告)日：2016-10-04
申请号：US13000516
申请日：2009-06-23
申请人： Markus Kalesse , Nisar Malek , Ronald Frank , Tobias Brodmann , Leila Bülow , Andreas Rentsch , Anna-Katharina Girbig , Ulrike Eggert
发明人： Markus Kalesse , Nisar Malek , Ronald Frank , Tobias Brodmann , Leila Bülow , Andreas Rentsch , Anna-Katharina Girbig , Ulrike Eggert
摘要： The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.
摘要翻译： 本发明涉及特定的大环化合物的用途，所述大环化合物是p27蛋白酶体降解的抑制剂，特别是其金属蛋白和其衍生物，用于各种病症的治疗，例如诱导免疫耐受性，自身免疫性疾病，细菌感染和 增殖性疾病，如癌症。
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6.发明申请Method for Producing Intermediates for the Production of Novel Macrocycles that are Inhibitors of the Proteasomic Degradation of p27, such as Argyrin and Derivatives Thereof, and Uses of Said Macrocycles 有权生产用于生产新型大环的中间体的方法，其为抑制p27的蛋白酶体降解，如Argyrin及其衍生物，以及所述大环的用途公开(公告)号：US20110311564A1
公开(公告)日：2011-12-22
申请号：US13000516
申请日：2009-06-23
申请人： Markus Kalesse , Leíla Bülow , Andreas Rentsch , Anna-Katharina Girbig , Ulrike Eggert , Nisar Malek , Ronald Frank , Tobias Brodmann
发明人： Markus Kalesse , Leíla Bülow , Andreas Rentsch , Anna-Katharina Girbig , Ulrike Eggert , Nisar Malek , Ronald Frank , Tobias Brodmann
摘要： The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.
摘要翻译： 本发明涉及特定的大环化合物的用途，所述大环化合物是p27蛋白酶体降解的抑制剂，特别是其金属蛋白和其衍生物，用于各种病症的治疗，例如诱导免疫耐受性，自身免疫性疾病，细菌感染和 增殖性疾病，如癌症。
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