Stereoselective synthesis of bicyclic heterocycles
    5.
    发明授权
    Stereoselective synthesis of bicyclic heterocycles 有权
    双环杂环的立体选择性合成

    公开(公告)号:US08658790B2

    公开(公告)日:2014-02-25

    申请号:US12846943

    申请日:2010-07-30

    IPC分类号: C07D239/72

    摘要: The present invention relates to a process for the stereoselective preparation of compounds of formulae (1A) and (1B) and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways.

    摘要翻译: 本发明涉及立体选择性制备式(1A)和(1B)化合物及其盐,特别是其与无机或有机酸和碱的生理上可接受的盐,其具有有价值的药理学性质,特别是抑制性 对由酪氨酸激酶介导的信号转导的作用,其用于治疗疾病,特别是肿瘤疾病以及良性前列腺增生(BPH),肺和气道疾病的用途。