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公开(公告)号:US20100120872A1
公开(公告)日:2010-05-13
申请号:US12557654
申请日:2009-09-11
申请人: Markus Rolf Dobler , Francois Lenoir , David Thomas Parker , Yunshan Peng , Grazia Piizzi , Sompong Wattanasin
发明人: Markus Rolf Dobler , Francois Lenoir , David Thomas Parker , Yunshan Peng , Grazia Piizzi , Sompong Wattanasin
IPC分类号: A61K31/44 , C07C233/16 , C12N1/20 , A61K31/16 , A61P31/04 , C07D213/00
CPC分类号: C07D309/22 , C07B2200/05 , C07C259/06 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D211/70 , C07D213/30 , C07D307/42 , C07D307/80
摘要: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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公开(公告)号:US20080255149A1
公开(公告)日:2008-10-16
申请号:US12088367
申请日:2006-09-25
申请人: Markus Rolf Dobler , Jonathan E. Grob , Arup Patnaik , Branko Radetich , Micheal Shultz , Yanyi Zhu
发明人: Markus Rolf Dobler , Jonathan E. Grob , Arup Patnaik , Branko Radetich , Micheal Shultz , Yanyi Zhu
IPC分类号: A61K31/4035 , C07D209/44 , C07C271/06 , C07D211/70 , A61K31/435 , A61K31/445 , A61K31/496 , A61P35/02 , A61P17/06 , A61P19/02 , A61P35/00 , A61K31/438 , A61K31/44 , A61K31/235 , C07D211/10 , C07D241/04
CPC分类号: C07D209/44 , C07D211/44 , C07D211/70 , C07D221/20 , C07D295/185 , C07D295/192 , C07D401/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/10
摘要: The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.
摘要翻译: 本发明涉及羧胺化合物及其盐在治疗HDAC依赖性疾病中的用途以及用于制备用于治疗所述疾病的药物制剂。
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公开(公告)号:US08372885B2
公开(公告)日:2013-02-12
申请号:US12557654
申请日:2009-09-11
申请人: Markus Rolf Dobler , Francois Lenoir , David Thomas Parker , Yunshan Peng , Grazia Piizzi , Sompong Wattanasin
发明人: Markus Rolf Dobler , Francois Lenoir , David Thomas Parker , Yunshan Peng , Grazia Piizzi , Sompong Wattanasin
IPC分类号: A61K31/19 , C07C229/00 , C07C259/04
CPC分类号: C07D309/22 , C07B2200/05 , C07C259/06 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D211/70 , C07D213/30 , C07D307/42 , C07D307/80
摘要: The present application describes organic compounds of a general formula: and salts, and isomers thereof, wherein R, R2 and R3 are defined in the specification. The compounds are useful for treating a gram-negative bacterial infection.
摘要翻译: 本申请描述了通式为的有机化合物及其盐及其异构体,其中R 1,R 2和R 3在本说明书中定义。 该化合物可用于治疗革兰氏阴性细菌感染。
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公开(公告)号:US20120142685A1
公开(公告)日:2012-06-07
申请号:US12594728
申请日:2008-04-04
申请人: Markus Rolf Dobler , Charles Francis Jewell, JR. , Erik Meredith , Lauren G. Monovich , Sarah Siska , Anette Von Matt , Maurice Van Eis , Taeyoung Yoon , Christoph Gaul , Michael Paul Capparelli
发明人: Markus Rolf Dobler , Charles Francis Jewell, JR. , Erik Meredith , Lauren G. Monovich , Sarah Siska , Anette Von Matt , Maurice Van Eis , Taeyoung Yoon , Christoph Gaul , Michael Paul Capparelli
IPC分类号: A61K31/5377 , C07D471/10 , A61K31/444 , A61P7/10 , A61P9/04 , A61P35/00 , A61P3/04 , A61P3/10 , C07D471/04 , A61K31/496
CPC分类号: C07D471/04
摘要: The present invention provides a compound formula I: (formula I) said compound is inhibitor of selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example MARK1/2/3, PKD-1/2/3, PKN-1/2, CDK-9, CaMKII, ROCK-I/II, inhibitors of histone deacetylase (HDAC) phosphorylation, or inhibitors of other kinases. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译: 本发明提供式I化合物:(式I)所述化合物是属于AGC或钙调蛋白激酶家族的激酶选择性亚型的抑制剂,例如MARK1 / 2/3,PKD-1/2/3,PKN -1/2,CDK-9,CaMKII,ROCK-I / II,组蛋白脱乙酰酶(HDAC)磷酸化抑制剂或其他激酶抑制剂。 最后,本发明还提供药物组合物。
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