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1.发明授权公开(公告)号：US07780618B2
公开(公告)日：2010-08-24
申请号：US11760826
申请日：2007-06-11
IPC分类号： A61M37/00
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides an apparatus and method for controlling a fluid separation system, preferably a blood apheresis system, by sensing fluid pressure and comparing the sensed fluid pressure to a threshold value.
摘要翻译： 本发明提供了一种用于通过检测流体压力并将感测到的流体压力与阈值进行比较来控制流体分离系统（优选血液分离系统）的装置和方法。
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公开(公告)号：US06613009B1
公开(公告)日：2003-09-02
申请号：US08914405
申请日：1997-08-19
IPC分类号： A61M3700
CPC分类号： A61M1/3624 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3639 , A61M1/3641 , A61M1/3652 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2205/12 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/3382 , A61M2205/3386 , A61M2205/505 , B04B5/0442 , B04B9/08 , B04B2005/045
摘要： An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
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公开(公告)号：US08088090B2
公开(公告)日：2012-01-03
申请号：US11530131
申请日：2006-09-08
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes at least a two-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.
摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法至少使用两级报警系统。 响应于系统中的压降而触发第一级报警条件以小于或等于指定的系统压力并在系统的至少一部分中暂停流体流动。 响应于指定时间内的指定数量的所述压降触发二级报警条件，并且降低系统中流体的流量。 报警条件也可能触发可见和/或声音报警。 当压降由非严重的，自分辨的或易于纠正的条件（例如系统部件的未对准）引起时，这些警报水平允许通过白细胞减少室流动。
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公开(公告)号：US07824355B2
公开(公告)日：2010-11-02
申请号：US12187988
申请日：2008-08-07
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
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公开(公告)号：US20090043237A1
公开(公告)日：2009-02-12
申请号：US12187988
申请日：2008-08-07
IPC分类号： A61M1/14
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
摘要翻译： 提出了用于血液处理的方法，装置和装置部件。 特别地，提出了用于将血液分离成血液成分并收集一种或多种分离的血液成分的方法，装置和装置部件，其减少血管浸润的发生率并增强供体的舒适度。 一方面，本发明提供了具有在返回时间内系统地减少的返回流速的血液处理方法。 另一方面，本发明提供了血液处理方法，其具有从受检者的总血液体积得到的去除流速，回流流量或两者。 另一方面，本发明提供了血液处理方法，其中选择相应于所收集的组分的去除血液的体积份数以优化血液处理效率并增强收集的血液成分的纯度。
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公开(公告)号：US06790195B2
公开(公告)日：2004-09-14
申请号：US09940955
申请日：2001-08-27
IPC分类号： A61M3700
CPC分类号： A61M1/3639 , A61M1/3624 , A61M1/3641 , A61M1/3652 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/505 , B04B5/0442 , B04B9/08 , B04B2005/045
摘要： An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis sytem in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing channel and the utilization of high packing factors for the procedure.
摘要翻译： 公开了一种体外血液处理系统，其包括各种新颖的组分，并且可以根据各种新颖的方法进行操作。 例如，该系统包括图形操作员界面，其指导操作者通过单采程序的各个方面。 此外，该系统还包括与将血液处理容器装载到血液处理通道中并且在完成手术之后移除血液处理通道相关的各种特征。 此外，该系统还包括与准备该过程一起使用至少部分单采系统的血液灌注相关的各种特征。 此外，该系统包括增强单采血液系统性能的各种特征，包括血液处理容器和血液处理通道之间的相互关系以及该程序的高填充因子的利用。
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公开(公告)号：US07608053B2
公开(公告)日：2009-10-27
申请号：US11530122
申请日：2006-09-08
CPC分类号： A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331
摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a return-flow alarm system. A return-flow alarm-triggering pressure is specified, and when pressure of the return flow in the system is higher than or equal to the specified pressure, a return-flow alarm is triggered.
摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法采用回流报警系统。 指定回流报警触发压力，当系统的回流压力大于或等于指定压力时，会触发回流报警。
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公开(公告)号：US07169352B1
公开(公告)日：2007-01-30
申请号：US10681035
申请日：2003-10-08
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.
摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法采用三级报警系统。 响应于系统中的压降而触发第一级报警条件以小于或等于指定的系统压力并在系统的至少一部分中暂停流体流动。 响应于指定时间内的指定数量的所述压降触发二级报警条件，并且降低系统中流体的流量。 报警条件也可能触发可见和/或声音报警。 当压降由非严重的，自分辨的或易于纠正的条件（例如系统部件的未对准）引起时，这些警报水平允许通过白细胞减少室流动。
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公开(公告)号：US06179801B2
公开(公告)日：2001-01-30
申请号：US09071293
申请日：1998-01-21
IPC分类号： A61M3700
CPC分类号： B04B5/0442 , A61M1/3624 , A61M1/3639 , A61M1/3641 , A61M1/3652 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/505 , B04B9/08 , B04B2005/045
摘要： An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
摘要翻译： 公开了一种体外血液处理系统，其包括各种新颖的组分，并且可以根据各种新颖的方法进行操作。 例如，该系统包括图形操作员界面，其指导操作者通过单采程序的各个方面。 此外，该系统还包括与将血液处理容器装载到血液处理通道中并且在完成手术之后移除血液处理通道相关的各种特征。 此外，该系统还包括与准备该过程一起使用至少部分单采血液系统的血液灌注相关的各种特征。 此外，该系统包括增强单采血液系统性能的各种特征，包括血液处理容器和血液处理容器之间的相互关系以及该程序的高填充因子的利用。
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公开(公告)号：US07513882B2
公开(公告)日：2009-04-07
申请号：US11530111
申请日：2006-09-08
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.
摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法采用三级报警系统。 响应于系统中的压降而触发第一级报警条件以小于或等于指定的系统压力并在系统的至少一部分中暂停流体流动。 响应于指定时间内的指定数量的所述压降触发二级报警条件，并且降低系统中流体的流量。 报警条件也可能触发可见和/或声音报警。 当压降由非严重的，自分辨的或易于纠正的条件（例如系统部件的未对准）引起时，这些警报水平允许通过白细胞减少室流动。
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