公开(公告)号：US20080075744A1

公开(公告)日：2008-03-27

申请号：US11824480

申请日：2007-06-29

申请人： John Hiserodt ,  Martin Graf ,  Gale Granger

发明人： John Hiserodt ,  Martin Graf ,  Gale Granger

IPC分类号： A61K35/00 ,  A61K39/00 ,  A61P43/00 ,  C12N15/87

CPC分类号： A61K35/13 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/5152 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/55533 ,  C07K14/525 ,  C07K14/535 ,  C07K14/5406 ,  C07K14/55 ,  C12N2510/02 ,  C12N2799/027 ,  A61K2300/00

摘要： This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a cytokine-secreting cell line. Tumor antigen may be provided in the form of primary tumor cells, tumor cell lines or tumor extracts prepared from the subject. In certain embodiments of the invention, the cytokine-secreting line is a separate tumor line that is allogeneic to the patient and genetically altered so as to produce a cytokine at an elevated level. Exemplary cytokines are IL-4, GM-CSF, IL-2, TNF-α, and M-CSF in the secreted or membrane-bound form. In these embodiments, the cytokine-producing cells provide immunostimulation in trans to generate a specific immune response against the tumor antigen. Vaccines may be tailored for each type of cancer or for each subject by mixing tumor antigen with a favorable number of cytokine-producing cells, or with a cocktail of such cells producing a plurality of cytokines at a favorable ratio.

摘要翻译： 本发明包括细胞疫苗及其在癌症免疫治疗中的使用方法，特别是在人类中。 疫苗包括肿瘤相关抗原的来源和细胞因子分泌细胞系。 可以以从受试者制备的原发性肿瘤细胞，肿瘤细胞系或肿瘤提取物的形式提供肿瘤抗原。 在本发明的某些实施方案中，细胞因子分泌系是与患者同种异体的遗传改变的单独的肿瘤细胞系，从而在升高的水平产生细胞因子。 示例性细胞因子是分泌或膜结合形式的IL-4，GM-CSF，IL-2，TNF-α和M-CSF。 在这些实施方案中，细胞因子产生细胞在反式中提供免疫刺激以产生针对肿瘤抗原的特异性免疫应答。 可以通过将肿瘤抗原与有利数量的产生细胞因子的细胞混合，或者以这样的细胞的混合物以有利的比例产生多种细胞因子，为每种类型的癌症或每个受试者定制疫苗。

公开(公告)号：US07173109B2

公开(公告)日：2007-02-06

申请号：US10964878

申请日：2004-10-14

申请人： Thilo Enderle ,  Martin Graf ,  Cornelia Hertel ,  Sannah Jensen Zoffmann ,  Eric Argirios Kitas

发明人： Thilo Enderle ,  Martin Graf ,  Cornelia Hertel ,  Sannah Jensen Zoffmann ,  Eric Argirios Kitas

IPC分类号： A61K38/00

CPC分类号： C07K14/60 ,  G01N31/22

摘要： The present invention relates to a fluorescently labeled growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, in particular by high throughput screening.

摘要翻译： 本发明涉及荧光标记的生长激素促分泌素，其可用于鉴定能够结合生长激素促分泌素受体的化合物，特别是通过高通量筛选。

公开(公告)号：US5351719A

公开(公告)日：1994-10-04

申请号：US768306

申请日：1993-03-29

申请人： Martin Graf

发明人： Martin Graf

IPC分类号： D03C9/06

CPC分类号： D03C9/0691 ,  D03C9/0675

摘要： A releasable corner structure for a heddle frame includes a projection carried by a side support, wherein the projection is received in a hollow space of a frame stave and is clamped in position by a clamping screw. The clamped projection is in the form of a flat body formed in one piece with the side support, and defines an outer frame having an opening within which flexible vibration dampers are positioned to lie between the outer frame of the projection and a metallic member that fits within and is spaced from the sides of the frame opening. The metallic member is riveted to a U-shaped sheet-metal casing that is adapted to surround the outer frame with a slight clearance space. Into the open top of the U-shaped sheet metal casing is riveted a rigid ledge member, against which the clamping screw acts. The side support projection is received within the frame stave and is separated therefrom by the vibration dampers, and therefore vibrations between the side support and the frame stave are damped and heddle frame breakage is prevented, especially when the machine in which the heddle frame is installed is operated at high speeds.

摘要翻译： PCT No.PCT / CH90 / 00035 Sec。 371日期1993年3月29日 102（e）1993年3月29日PCT 1990年2月14日提交PCT公布。 公开号WO91 / 12360 PCT 日期：1991年8月22日。综框的可释放的角结构包括由侧支撑承载的突起，其中突出部被容纳在框架的中空空间中并且通过夹紧螺钉被夹紧就位。 被夹紧的突起是与侧支架形成为一体的平坦体的形式，并且限定了具有开口的外框架，柔性减震器定位在该开口内，以位于突起的外框架和适合的金属构件之间 在框架开口的两侧之间并与之隔开。 金属构件被铆接到适于围绕外框架的微小间隙空间的U形金属板壳体。 在U形金属板壳体的开口顶部铆接有刚性凸缘构件，夹紧螺钉与该刚性凸缘构件作用。 侧支撑突起容纳在框架壁内并且通过减振器与其分离，因此侧支撑件和框架板之间的振动被阻尼，并且防止了整齐的框架断裂，特别是当其中装有综框的机器时 以高速运行。

公开(公告)号：US4462433A

公开(公告)日：1984-07-31

申请号：US423166

申请日：1982-09-24

申请人： Martin Graf

发明人： Martin Graf

IPC分类号： D03D51/30 ,  D03D51/24 ,  D03D51/28

CPC分类号： D03D51/24

摘要： A warp stop motion apparatus includes individual disengageable coupling and control elements which have fork-like ends that are capable of surrounding the lateral sides of drive pins extending outwardly from the opposite sides of the end portions of the respective inner movable serrated bars which slidingly extend into a housing part that is oscillated back and forth by an individual electrical motor. Oscillation of the housing part causes the inner serrated bars to oscillate in their longitudinal direction with respect to outer stationary serrated bars in which they are positioned. Separate adjustable spring loaded locking cams act to keep each coupling and control element in position; however, if an inner serrated bar becomes blocked with respect to its movement relative to the associated outer serrated bar due to drop wire falling across the teeth thereof, the associated coupling and control element will rotate, causing a contact spring to close an electrical circuit which activates a switch to stop the weaving machine and the oscillating movement of the housing part.

摘要翻译： 翘曲停止运动装置包括单独的可脱离联接和控制元件，其具有叉形端部，其能够围绕驱动销的横向侧面，驱动销的侧面从相应的内部可移动锯齿形杆的端部的相对侧向外延伸，滑动延伸到 由单独的电动机来回摆动的壳体部。 壳体部件的振荡使得内部锯齿形杆相对于它们所定位的外侧固定锯齿形杆在其纵向方向上摆动。 单独的可调弹簧加载锁定凸轮用于将每个联轴器和控制元件保持在适当位置; 然而，如果内部锯齿形杆相对于由于下落线落在其齿上而相对于相关联的外部锯齿状杆的移动而被阻挡，则相关联的联接和控制元件将旋转，导致接触弹簧闭合电路， 启动开关以停止织机和壳体部件的摆动。

公开(公告)号：US4155379A

公开(公告)日：1979-05-22

申请号：US882156

申请日：1978-02-28

申请人： Martin Graf

发明人： Martin Graf

IPC分类号： D03C9/04 ,  D03C9/02

CPC分类号： D03C9/02

摘要： The heddles of a weaving machine have vibration absorbing material on the end loops thereof which normally contact edges of metal rods mounted on a heddle frame for oscillating movement, the heddles effecting a lifting movement relative to the rods upon oscillation thereof. Metal-to-metal contact between the end loops and the rods is therefore avoided so as to reduce noise during operation of the machine and so as to avoid corrosion of the heddles and the rods.

摘要翻译： 编织机的综丝在其端部环上具有振动吸收材料，其通常接触安装在综框上的金属杆的边缘以进行摆动运动，所述综丝在振荡时相对于杆进行提升运动。 因此避免了端环和杆之间的金属对金属的接触，以便在机器操作期间减少噪音并且避免综丝和杆的腐蚀。

公开(公告)号：US3990481A

公开(公告)日：1976-11-09

申请号：US585630

申请日：1975-06-10

申请人： Martin Graf

发明人： Martin Graf

IPC分类号： D03C7/06 ,  D03C7/02

CPC分类号： D03C7/02

摘要： A wear resistant leno heddle is disclosed which has a doup and two lifting heddles. The lifting heddles are formed in one piece by moulding a plastic material. The moulding technique allows the lifting heddles to be formed with varying cross-sectional dimensions according to the required strength of a given area. Reinforcing members may also be embedded within the lifting heddles to further increase its structural strength.

摘要翻译： 公开了一种耐磨的罗拉综丝，其具有多针和两个提升综丝。 起重综丝通过模制塑料材料形成为一体。 成型技术允许提升综丝根据给定面积的所需强度形成具有变化的横截面尺寸。 加强构件也可以嵌入提升综丝以进一步增加其结构强度。

公开(公告)号：US3949789A

公开(公告)日：1976-04-13

申请号：US556034

申请日：1975-03-06

申请人： Martin Graf

发明人： Martin Graf

IPC分类号： D03C9/06

CPC分类号： D03C9/0683

摘要： A frame stave for the head frame of a weaving machine is extruded with a closed, internal T shaped channel 10 in its upper edge. When the location of connecting hooks 5 is determined, a portion of the top edge of the stave is machined away at 6 to enable the hooks to be attached to the stave by screws 8 and sliding inserts 9 within the channel.

摘要翻译： 用于织机的头框的框架壁在其上边缘处被封闭的内部T形通道10挤压。 当确定连接钩5的位置时，壁板的顶部边缘的一部分被加工成6以使钩能够通过螺钉8和滑动插入件9附接到通道内。

公开(公告)号：US06369368B2

公开(公告)日：2002-04-09

申请号：US09872119

申请日：2001-06-01

申请人： Martin Graf ,  Martin Lohner

发明人： Martin Graf ,  Martin Lohner

IPC分类号： H05B306

CPC分类号： F24H9/1863 ,  Y10T403/21

摘要： The invention concerns an expanding device (1) comprising two parts (heating elements 3,4) which can be moved relative to one another against the action of a spring element (11), wherein the spring element (11) is disposed between the two parts (heating elements 3,4) and abuts both parts (heating elements 3,4) with one external leg (12,13) each, a tensioning element (21) which can be displaced at a right angle to the direction of movement (14,15) of the two parts (heating elements 3,4) and is surrounded by a central connecting leg (18) of the spring element (11), and a counter bearing (20) on which the connecting leg (18) is supported in a tensioning direction (21′) of the tensioning element (21), wherein at least in the tension-free state, a section (16,17) of the connecting leg (18) cooperating with the tensioning element (21) in the tensioning direction (21′) is oriented at an inclined angle to the tensioning direction (21′) thereby forcing the parts to an abutment or wall and holding them in position.

摘要翻译： 本发明涉及一种膨胀装置（1），包括两个部分（加热元件3,4），该部分可以相对于弹簧元件（11）的作用相对于彼此移动，其中弹簧元件（11）设置在两个 部件（加热元件3,4）并且与一个外部腿部（12,13）分别邻接两个部件（加热元件3,4），可以与运动方向成直角位移的张紧元件（21） 两个部分（加热元件3,4）的四周（14,15）和由弹簧元件（11）的中心连接腿（18）围绕的一个反作用轴承（20），连接脚（18） 支撑在张紧元件（21）的张紧方向（21'）上，其中至少在无张力状态下，连接腿部（18）的与张紧元件（21）配合的部分（16,17） 张紧方向（21'）被定向成与张紧方向（21'）成倾斜的角度，从而迫使部件到邻接或壁面并保持 将它们置于适当位置。

公开(公告)号：US4715409A

公开(公告)日：1987-12-29

申请号：US927165

申请日：1986-11-05

申请人： Martin Graf

发明人： Martin Graf

IPC分类号： D03C13/00 ,  D03C1/14 ,  D03C9/00 ,  D03C9/06

CPC分类号： D03C9/0683 ,  D03C1/144 ,  D03C9/00

摘要： One coupling element secured to a heddle frame has a pivotally mounted bolt latch for interlocking with another coupling element connected to a drive member when the another element is inserted in an opening of the one element to couple the heddle frame with the drive member. Toothing on the bolt latch and toothing on the another coupling element come into the locking position by a toggle lever pivotally mounted on the one element. The toggle lever has a manual operating lever, and a further lever element hinged thereon and comprising a bolt-shaped part surrounded by a tensioned helical compression spring which is supported between two abutments which are constructed as hinges for connection of the lever to the manual operating lever and to the bolt latch. One abutment is fixed to the bolt, and the other abutment is slidable relative to the bolt to a limited longitudinal extent determined by stops formed by an over-sized bore in the hinge receiving a pin carried by the bolt. In the over dead-center position of the toggle lever, in which the bolt latch is urged into the locking position, a cam-shaped projection on the manual operating lever abuts against an angled end of the L-shaped bolt latch. This mutual support is also present when, as a result of wear of the toothing, the bolt latch allows itself to be pressed slightly further, and the manual operating lever modifies its pivoting end position accordingly under the action of the spring. Thereby self-adjustment is ensured and the occurrence of play between the coupling elements is prevented.

摘要翻译： 固定到综框的一个联接元件具有枢转安装的螺栓闩锁，用于当另一个元件插入到该元件的开口中以将综框与驱动构件连接时，与连接到驱动构件的另一联接元件互锁。 通过枢转地安装在一个元件上的肘节杆，在螺栓闩锁和另一个联接元件上的齿部上的紧固件进入锁定位置。 肘节杆具有手动操作杆和铰接在其上的另一杠杆元件，并且包括被张紧的螺旋压缩弹簧包围的螺栓形部分，所述螺旋形部分被支撑在两个邻接部之间，所述两个支座被构造成用于将杠杆连接到手动操作 杠杆和螺栓闩锁。 一个支座固定在螺栓上，另一个支座可相对于螺栓滑动到有限的纵向范围内，该纵向尺寸由接收由螺栓承载的销钉的铰链中的尺寸较大的孔形成的止动件确定。 在肘杆的过度中心位置，其中螺栓闩锁被推入锁定位置，手动操作杆上的凸轮形突起抵靠L形螺栓闩锁的倾斜端。 当由于齿的磨损而导致螺栓闩锁允许其稍微进一步按压时，这种相互支撑也存在，并且手动操作杆相应地在弹簧的作用下修改其枢转端部位置。 从而确保了自调整，并且防止了联接元件之间的间隙的发生。

公开(公告)号：US4646789A

公开(公告)日：1987-03-03

申请号：US863889

申请日：1986-04-07

申请人： Martin Graf

发明人： Martin Graf

IPC分类号： D03D51/30 ,  D03D51/28

CPC分类号： D03D51/28

摘要： A contact bar assembly for the warp stop motion of a loom includes an inner bar (1) having a beam-shaped part (2) of insulating material at the upper edge of which a groove (5) is provided for the reception of a metallic serrated bar (6), and the entire inner bar can longitudinally reciprocate in an outer bar (8) of a U-shaped cross section. The outer bar (8) has longitudinally spaced slots (12) each for the reception of a guide piece (12) of synthetic material which can easily be inserted and removed, each guide piece having a longitudinal slot (13) with a larger configuration (14) at its lower section. The beam-shaped part (2) of synthetic material has a lower section of T-shaped cross-section (4) and (10) which engages with slot (13) and its larger configuration (14) for holding and guiding the inner bar (1) in such a manner that a vertical separation of the inner bar from the outer bar is prevented, although the inner bar is capable of longitudinal reciprocation in the outer bar (8). The longitudinal edge of the inner bar located beyond the free ends of the legs of the U shaped outer bar has about the same thickness as the outer bar and covers a slot (9) of the outer bar (8) to prevent entry of fluff and dust.

摘要翻译： PCT No.PCT / CH84 / 00125 Sec。 一九八六年四月七日 102（e）日期1986年4月7日PCT提交1984年8月9日PCT公布。 出版物WO86 / 01236 日本1986年2月27日。用于织机的翘曲停止运动的接触杆组件包括：内杆（1），其具有在其上边缘处具有凹槽（5）的绝缘材料的梁形部分（2） 提供用于接收金属锯齿形杆（6），并且整个内杆可以在U形横截面的外杆（8）中纵向往复运动。 外杆（8）具有纵向间隔开的狭槽（12），每个狭槽（12）用于接收能够容易地插入和拆卸的合成材料的引导件（12），每个引导件具有较大构造的纵向槽（13） 14）在其下部。 合成材料的梁形部分（2）具有与槽（13）接合的T形横截面（4）和（10）的下部，并且其较大的构造（14）用于保持和引导内杆 （1），尽管内杆能够在外杆（8）中纵向往复运动，但是防止了内杆与外杆的垂直分离。 位于U型外侧杆的腿部的自由端之外的内侧杆的纵向边缘具有与外侧杆大致相同的厚度并且覆盖外部杆（8）的狭槽（9），以防止绒毛进入，并且 灰尘。