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公开(公告)号:US20100136130A1
公开(公告)日:2010-06-03
申请号:US12596401
申请日:2008-04-15
申请人: Matthias Seiler , Martin Haneke , Henning Marckmann , Stephan Pilz , Muhammad Irfan , Saskia Klee-Laquai , Geoffrey Hills , Mike Farwick , Peter Lersch , Axel Kobus
发明人: Matthias Seiler , Martin Haneke , Henning Marckmann , Stephan Pilz , Muhammad Irfan , Saskia Klee-Laquai , Geoffrey Hills , Mike Farwick , Peter Lersch , Axel Kobus
IPC分类号: A61K36/736 , A61K9/14 , A61P43/00
CPC分类号: A61K36/00
摘要: The present invention relates to a preparation comprising at least one encapsulation material and at least one bioactive natural substance, which bioactive natural substance can be released from the preparation in a controlled manner, wherein the encapsulation material comprises at least one glyceride with a melting point of at least 35° C. and additionally at least one polymer with polyester units, which has a melting temperature of at least 30° C. and a viscosity in the range from 50 mPa*s to 250 Pa*s, measured by means of rotational viscometry at 110° C. The present invention further describes processes for producing the preparation of the invention, as well as preferred uses.
摘要翻译: 本发明涉及包含至少一种包封材料和至少一种生物活性天然物质的制剂,所述生物活性天然物质可以以受控的方式从所述制剂中释放,其中所述包封材料包含至少一种甘油酯,其熔点为 至少35℃,另外具有至少一种具有聚酯单元的聚合物,其具有至少30℃的熔融温度和在50mPa * s至250Pa * s范围内的粘度,其通过旋转 本发明还描述了制备本发明制剂的方法以及优选的用途。
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公开(公告)号:US20130338324A1
公开(公告)日:2013-12-19
申请号:US13903546
申请日:2013-05-28
申请人: Christine Beierlein , Niko Haberkorn , Michael Korell , Thomas Gruenfelder , Norbert Richter , Michael Oldenkott , Juergen Pospiech , Martin Haneke , Andreas Berlineanu , Peter Denkinger , Juergen Hellwig
发明人: Christine Beierlein , Niko Haberkorn , Michael Korell , Thomas Gruenfelder , Norbert Richter , Michael Oldenkott , Juergen Pospiech , Martin Haneke , Andreas Berlineanu , Peter Denkinger , Juergen Hellwig
IPC分类号: C08F2/06
摘要: A process for polymerization of a diene is provided. The process comprises: a) reacting the diene with hydrogen peroxide in a hydrophilic organic solvent in the presence of water to obtain a polymerization reaction mixture; b) contacting the polymerization reaction mixture with water having a temperature of from 20 to 80° C. to form a mixture having an organic phase and an aqueous phase; c) removing unreacted gaseous diene from the water mixture obtained in b); d) separating the aqueous phase comprising the hydrophilic solvent from the organic phase of the water mixture; and e) distilling volatile materials from the separated organic phase from d) to obtain the polymerization product; wherein a temperature of the reaction a) is from 50-150° C., a pressure of the reaction a) is from 0 to 50 bar, the unreacted gaseous diene removed in c) is condensed, distilled and the distillate obtained reacted according to a), and the hydrophilic solvent is recovered from the separated aqueous phase and reused according to a). Also provided is an apparatus for conducting the process of the invention.
摘要翻译: 提供二烯聚合方法。 该方法包括:a)在水存在下使二烯与过氧化氢在亲水性有机溶剂中反应,得到聚合反应混合物; b)使聚合反应混合物与温度为20至80℃的水接触以形成具有有机相和水相的混合物; c)从b)中得到的水混合物中除去未反应的气态二烯; d)将包含亲水溶剂的水相与水混合物的有机相分离; 和e)从分离的有机相中蒸馏挥发性物质,从d)得到聚合产物; 其中反应a)的温度为50-150℃,反应a)的压力为0至50巴,将在c)中除去的未反应的气体二烯冷凝,蒸馏,得到的馏出物根据 a),并且从分离的水相中回收亲水性溶剂,并根据a)重复使用。 还提供了用于进行本发明的方法的装置。
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