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    Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
    1.
    发明授权
    Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same 失效
    来自长链多不饱和脂肪酸的牛痘素及其制备和使用方法

    公开(公告)号：US07884131B2

    公开(公告)日：2011-02-08

    申请号：US11284790

    申请日：2005-11-21

    Applicant: Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Van Elswyk

    Inventor： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Van Elswyk

    IPC: A61K31/22 ,  C07C59/00 ,  C07C57/00

    CPC classification number: C12P7/6472 ,  C07C59/42 ,  C07D303/38 ,  C12P7/6427

    Abstract: Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.

    Abstract translation: 公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为多糖类，以及制备和使用这种oxylipin的方法。 还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6） 作为生产新型oxylipins的底物，以及由此产生的oxylipin。 还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是 作为抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，尤其是二十二烷酸。

    Products containing highly unsaturated fatty acids for use by women during stages of preconception, pregnancy and lactation/post-partum
    2.
    发明授权
    Products containing highly unsaturated fatty acids for use by women during stages of preconception, pregnancy and lactation/post-partum 有权
    含有高度不饱和脂肪酸的产品，用于妇女在孕前，怀孕和哺乳期/产后阶段使用

    公开(公告)号：US08349895B2

    公开(公告)日：2013-01-08

    申请号：US12111844

    申请日：2008-04-29

    Applicant: Mary Van Elswyk

    Inventor： Mary Van Elswyk

    IPC: A61K31/194 ,  A61K31/202 ,  A61K33/42

    CPC classification number: A23D9/00 ,  A23L33/12 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/202 ,  G06Q90/00

    Abstract: A method and product for improving maternal and child health through nutrition. Omega-6 fatty acid and/or omega-3 fatty acid are provided to a woman and/or child prior to, during and/or after pregnancy to improve the health of the woman and her child. The ratios of the omega-6 and omega-3 fatty acids vary during various stages, e.g., pre-pregnancy, pregnancy and post-pregnancy. The omega-6 and omega-3 fatty acids can be in a variety of forms, such as at least one of highly purified algal oil comprising 70% by weight or more of the desired HUFA, triglyceride oil combined with phospholipid, phospholipid, protein and phospholipid combination, or dried marine microalgae.

    Abstract translation: 通过营养改善母婴健康的方法和产品。 在怀孕之前，期间和/或之后，向女性和/或儿童提供ω-6脂肪酸和/或ω-3脂肪酸，以改善女性和她的孩子的健康。 ω-6和ω-3脂肪酸的比例在各个阶段中变化，例如怀孕前，怀孕和怀孕后。 ω-6和ω-3脂肪酸可以是各种形式，例如至少一种高度纯化的藻油，其包含70重量％以上的所需HUFA，甘油三酯油与磷脂，磷脂，蛋白质和蛋白质组合， 磷脂组合或干海洋微藻。

    Oxylipins From Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
    3.
    发明申请
    Oxylipins From Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same 审中-公开
    来自长链多不饱和脂肪酸的Oxylipins及其制备和使用方法

    公开(公告)号：US20110178047A1

    公开(公告)日：2011-07-21

    申请号：US12981261

    申请日：2010-12-29

    Applicant: Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Van Elswyk

    Inventor： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Van Elswyk

    IPC: A61K31/202 ,  C07C59/42 ,  A61K31/616 ,  A61P29/00 ,  A61P25/28

    CPC classification number: C12P7/6472 ,  C07C59/42 ,  C07D303/38 ,  C12P7/6427

    Abstract: Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.

    Abstract translation: 公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为多糖类，以及制备和使用这种oxylipin的方法。 还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6） 作为生产新型oxylipins的底物，以及由此产生的oxylipin。 还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是 作为抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，尤其是二十二烷酸。

    Products Containing Highly Unsaturated Fatty Acids for Use by Women During Stages of Preconception, Pregnancy and Lactation/Post-Partum
    6.
    发明申请
    Products Containing Highly Unsaturated Fatty Acids for Use by Women During Stages of Preconception, Pregnancy and Lactation/Post-Partum 有权
    含有高度不饱和脂肪酸的产品在孕前，哺乳期和哺乳期/产后阶段使用妇女

    公开(公告)号：US20080226745A1

    公开(公告)日：2008-09-18

    申请号：US12111844

    申请日：2008-04-29

    Applicant: Mary Van Elswyk

    Inventor： Mary Van Elswyk

    IPC: A61K31/194 ,  A61K31/202 ,  A61K33/42

    CPC classification number: A23D9/00 ,  A23L33/12 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/202 ,  G06Q90/00

    Abstract: A method and product for improving maternal and child health through nutrition. Omega-6 fatty acid and/or omega-3 fatty acid are provided to a woman and/or child prior to, during and/or after pregnancy to improve the health of the woman and her child. The ratios of the omega-6 and omega-3 fatty acids vary during various stages, e.g., pre-pregnancy, pregnancy and post-pregnancy. The omega-6 and omega-3 fatty acids can be in a variety of forms, such as at least one of highly purified algal oil comprising 70% by weight or more of the desired HUFA, triglyceride oil combined with phospholipid, phospholipid, protein and phospholipid combination, or dried marine microalgae.

    Abstract translation: 通过营养改善母婴健康的方法和产品。 在怀孕之前，期间和/或之后，向女性和/或儿童提供ω-6脂肪酸和/或ω-3脂肪酸，以改善女性和她的孩子的健康。 ω-6和ω-3脂肪酸的比例在各个阶段中变化，例如怀孕前，怀孕和怀孕后。 ω-6和ω-3脂肪酸可以是各种形式，例如至少一种高度纯化的藻油，其包含70重量％以上的所需HUFA，甘油三酯油与磷脂，磷脂，蛋白质和蛋白质组合， 磷脂组合或干海洋微藻。

    Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation
    7.
    发明申请
    Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation 审中-公开
    预防性二十二碳六烯酸治疗亚临床炎症患者

    公开(公告)号：US20060069159A1

    公开(公告)日：2006-03-30

    申请号：US11223128

    申请日：2005-09-12

    Applicant: Linda Arterburn ,  James Hoffman ,  Harry Oken ,  Mary Van Elswyk

    Inventor： Linda Arterburn ,  James Hoffman ,  Harry Oken ,  Mary Van Elswyk

    IPC: A61K31/202

    CPC classification number: A61K45/06 ,  A61K31/202 ,  A61K31/232 ,  A61K31/60 ,  A61K2300/00

    Abstract: This invention is directed to methods and compositions which impede the development and progression of diseases associated with subclinical inflammation. Subclinical inflammation is commonly associated with atherosclerotic cardiovascular disease, coronary disease or cerebrovascular disease. The methods and compositions of the invention are also particularly suited to providing therapy for subclinical inflammation in diabetic and prediabetic patients. Methods of the invention comprise administration of DHA alone and in combination with antiplatelet drugs.

    Abstract translation: 本发明涉及妨碍与亚临床炎症相关的疾病的发展和进展的方法和组合物。 亚临床炎症通常与动脉粥样硬化性心血管疾病，冠心病或脑血管疾病有关。 本发明的方法和组合物还特别适用于在糖尿病和糖尿病患者中提供亚临床炎症的治疗。 本发明的方法包括单独给予DHA并与抗血小板药物组合。

    OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME
    8.
    发明申请
    OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
    来自长链多脂脂肪酸的氧化锌及其制备和使用方法

    公开(公告)号：US20110190389A1

    公开(公告)日：2011-08-04

    申请号：US12531344

    申请日：2008-02-20

    Applicant: Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Dutt Vinjamoori ,  Mary Van Elswyk

    Inventor： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Dutt Vinjamoori ,  Mary Van Elswyk

    IPC: A61K31/336 ,  A61K31/202 ,  C07C57/03 ,  A61P29/00 ,  C12P7/64 ,  C12P17/02 ,  C07D303/38 ,  A61P25/28

    CPC classification number: A61K31/202 ,  A23L33/12 ,  A61K8/361 ,  A61K31/60 ,  A61K45/06 ,  A61Q19/00 ,  C07C59/42 ,  C07D303/36 ,  C07D303/48 ,  A61K2300/00

    Abstract: Disclosed are novel oxylipins, referred to herein as docosanoids and eicosanoids, that are derived from C22 polyunsaturated fatty acids and from C20 polyunsaturated fatty acids, respectively, and methods of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6), docosatrienoic acid (C22:3n-3) (DTrAn-3), docosadienoic acid (C22:2n-6) (DDAn-6), eicosatrienoic acid (C20:3n-3) (ETrAn-3) eicosapentaenoic acid and arachidonic acid as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of LCPUF A-derived oxylipins, and particularly, docosanoids.

    Abstract translation: 公开了分别衍生自C22多不饱和脂肪酸和C20多不饱和脂肪酸的新型牛脂素，本文称为二十二烷酸类和类二十烷酸，以及制备和使用这些牛脂素的方法。 还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6） ，二十二碳三烯酸（C22：3n-3）（DTrAn-3），二十二碳烯酸（C22：2n-6）（DDAn-6），二十碳三烯酸（C20：3n-3）（ETrAn-3）二十碳五烯酸和花生四烯酸 作为生产新型oxylipins的底物，以及由此产生的oxylipin。 还公开了在治疗和营养或美容应用中使用DPAn-6，DPAn-3，DTAn-6和/或由其衍生的oxylipin，和/或衍生自C22脂肪酸结构的新型二醇类，特别是作为 抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸（LCPUF A）的油和组合物的新方法，其含有增强和有效量的LCPUF A衍生的草甘膦脂类，特别是二十二烷酸。

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