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公开(公告)号:US20060142301A1
公开(公告)日:2006-06-29
申请号:US11100355
申请日:2005-04-06
申请人: Alan Hutchison , Bertrand Chenard , James Tarrant , Guiying Li , Manuka Ghosh , George Luke , John Peterson , Wallace Pringle , Mary-Margaret O'Donnell , Kyungae Lee , Linda Gustavson , Dario Doller
发明人: Alan Hutchison , Bertrand Chenard , James Tarrant , Guiying Li , Manuka Ghosh , George Luke , John Peterson , Wallace Pringle , Mary-Margaret O'Donnell , Kyungae Lee , Linda Gustavson , Dario Doller
IPC分类号: A61K31/496 , A61K31/497 , C07D403/02
CPC分类号: C07D213/74 , C07D213/82 , C07D471/04 , C07D487/04 , C07D487/08
摘要: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译: 提供了式I化合物,其中变量如本文所述:这样的化合物可用于在体内或体外调节MCH与MCH受体的结合,并且特别可用于治疗各种代谢,进食和性障碍 在人类,驯养的伴侣动物和家畜中。 还提供了用于治疗这种病症的药物组合物和方法,以及使用这些配体检测MCH受体的方法(例如受体定位研究)。
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公开(公告)号:US20070249616A1
公开(公告)日:2007-10-25
申请号:US11763926
申请日:2007-06-15
申请人: Alan Hutchison , Bertrand Chenard , James Tarrant , Guiying Li , Manuka Ghosh , George Luke , John Peterson , Wallace Pringle , Mary-Margaret O'Donnell , Kyungae Lee , Linda Gustavson , Dario Doller
发明人: Alan Hutchison , Bertrand Chenard , James Tarrant , Guiying Li , Manuka Ghosh , George Luke , John Peterson , Wallace Pringle , Mary-Margaret O'Donnell , Kyungae Lee , Linda Gustavson , Dario Doller
IPC分类号: A61K31/496 , A61K31/498 , A61P3/04
CPC分类号: C07D213/74 , C07D213/82 , C07D471/04 , C07D487/04 , C07D487/08
摘要: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译: 提供了式I化合物,其中变量如本文所述:这样的化合物可用于在体内或体外调节MCH与MCH受体的结合,并且特别可用于治疗各种代谢,进食和性障碍 在人类,驯养的伴侣动物和家畜中。 还提供了用于治疗这种病症的药物组合物和方法,以及使用这些配体检测MCH受体的方法(例如受体定位研究)。
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公开(公告)号:US20060009456A1
公开(公告)日:2006-01-12
申请号:US11154986
申请日:2005-06-16
申请人: Alan Hutchinson , Bertrand Chenard , Guiying Li , Manuka Ghosh , James Tarrant , Taeyoung Yoon , George Luke , Kyungae Lee , Mary-Margaret O'Donnell , Wallace Pringle , John Peterson , Kevin Hodgetts , Cheryl Steenstra , Dario Doller
发明人: Alan Hutchinson , Bertrand Chenard , Guiying Li , Manuka Ghosh , James Tarrant , Taeyoung Yoon , George Luke , Kyungae Lee , Mary-Margaret O'Donnell , Wallace Pringle , John Peterson , Kevin Hodgetts , Cheryl Steenstra , Dario Doller
IPC分类号: A61K31/498 , A61K31/497 , A61K31/496 , C07D403/02 , C07D487/04
CPC分类号: C07D295/073 , C07D207/08 , C07D207/12 , C07D207/26 , C07D207/38 , C07D211/18 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/52 , C07D211/74 , C07D213/64 , C07D213/74 , C07D213/82 , C07D231/12 , C07D233/54 , C07D233/56 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/08 , C07D275/02 , C07D295/088 , C07D295/096 , C07D295/192 , C07D307/20 , C07D307/79 , C07D307/82 , C07D309/06 , C07D309/12 , C07D311/14 , C07D401/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
摘要: Aryl-substituted piperazine derivatives are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译: 提供了芳基取代的哌嗪衍生物。 这样的化合物可用于在体内或体外调节MCH受体活性,并且特别可用于治疗人,驯养伴侣动物和家畜中的各种代谢,喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法,以及使用这些配体检测MCH受体的方法(例如受体定位研究)。
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