公开(公告)号：US20240362466A1

公开(公告)日：2024-10-31

申请号：US18308167

申请日：2023-04-27

申请人： International Business Machines Corporation ,  Massachusetts Institute Of Technology

发明人： Ramon Fernandez Astudillo ,  Andrew Drozdov ,  Jiawei Zhou ,  Radu Florian ,  Tahira Naseem ,  Yoon Hyung Kim

IPC分类号： G06N3/0475 ,  G06N3/047 ,  G06N5/045

CPC分类号： G06N3/0475 ,  G06N3/047 ,  G06N5/045

摘要： Systems, computer-implemented methods, and computer program products to facilitate reducing error propagation when combining generative aligners and transition-based aligners are provided. According to an embodiment, a system can comprise a processor that executed components stored in memory. The computer executable components comprise a generative alignment component, an error propagation component, a discriminative parser, and a stochastic oracle policy component. The error propagation component can compute a posterior distribution over one or more hard alignments of parts given a pair of the generative alignment component. The discriminative parser can be trained via the stochastic oracle policy component to reduce error propagation when combining the generative alignment component with the discriminative parser.

公开(公告)号：US20240358502A1

公开(公告)日：2024-10-31

申请号：US18655491

申请日：2024-05-06

申请人： Children's Medical Center Corporation ,  President and Fellows of Harvard College ,  Massachusetts Institute of Technology

发明人： Sophie-Charlotte Hofferberth ,  Pedro J. del Nido ,  Elazer R. Edelman ,  Peter E. Hammer ,  Christopher Payne

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2433 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0013 ,  A61F2250/0004 ,  A61F2250/0065 ,  A61F2250/0082

摘要： A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.

公开(公告)号：US12131276B2

公开(公告)日：2024-10-29

申请号：US15409653

申请日：2017-01-19

申请人： Massachusetts Institute of Technology

发明人： Carlo Filippo Ratti ,  Giovanni Resta ,  Paolo Santi

IPC分类号： G06Q10/00 ,  G06Q10/0631 ,  G06Q50/00 ,  G06Q50/40 ,  G08G1/00

CPC分类号： G06Q10/06313 ,  G06Q10/06315 ,  G06Q50/40 ,  G08G1/202

摘要： Real-time, point-to-point, on-demand ride dispatching system. The system provides for optimal operation including a fleet dimensioning module for determining an optimal number of vehicles in a fleet needed to serve a collection of trip requests, and a vehicle dispatching module for dispatching the fleet of vehicles to serve a selected number of trip requests. The fleet dimensioning module employs a shareability network to model trip requests that can be served by a same vehicle to find the minimum number of vehicles in the fleet to serve all trip requests in the collection of trip requests.

公开(公告)号：US12130281B2

公开(公告)日：2024-10-29

申请号：US17404286

申请日：2021-08-17

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College

发明人： Armon R. Sharei ,  Marc Lajoie ,  Klavs F. Jensen ,  Robert S. Langer

IPC分类号： G01N33/487 ,  C12N15/87 ,  G01N33/50 ,  C12Q1/00

CPC分类号： G01N33/5002 ,  C12N15/87 ,  G01N33/48721 ,  C12Q1/00

摘要： Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described.

公开(公告)号：US12126324B2

公开(公告)日：2024-10-22

申请号：US18558207

申请日：2022-05-06

申请人： Massachusetts Institute of Technology

发明人： David J. Perreault ,  Jessica Boles ,  Jeffrey H. Lang ,  Joseph Bonavia

IPC分类号： H03H9/17

CPC分类号： H03H9/17

摘要： Described are structures and techniques for providing high-efficiency, high-power-density piezoelectric resonators (PRs) for use in power converters. In some embodiments, a power converter can include a PR for energy transfer, where the PR substantially satisfies geometry conditions disclosed herein for achieving high-efficiency and high-power-density. The geometry conditions can be defined in terms of the converter's specified (e.g., rated) voltage and power level.

公开(公告)号：US20240346352A1

公开(公告)日：2024-10-17

申请号：US18294259

申请日：2022-08-02

申请人： President and Fellows of Harvard College ,  Massachusetts Institute of Technology

发明人： Dolev Bluvstein ,  Harry Jay Levne ,  Giulia Semeghini ,  Tout WANG ,  Sepehr Ebadi ,  Alexander Keesling Contreras ,  Mikhail D. Lukin ,  Markus Greiner ,  Vladan Vuletic

IPC分类号： G06N10/40 ,  G06N10/20 ,  G06N10/70

CPC分类号： G06N10/40 ,  G06N10/20 ,  G06N10/70

摘要： Dynamically reconfigurable architectures for quantum information and simulation are provided. A plurality of neutral atoms is provided. Each neutral atom is disposed in a corresponding optical trap. Each of the plurality of neutral atoms is prepared in a mF=0 clock state. A pair of neutral atoms of the plurality of neutral atoms is entangled by directing a laser pulse thereto. The laser pulse is configured to transition the pair of neutral atoms through a Rydberg state. The optical trap corresponding to at least one neutral atom of the pair is adiabatically moved, thereby moving one atom of the pair relative to the other atom of the pair without destroying entanglement of the pair.

公开(公告)号：US20240344991A1

公开(公告)日：2024-10-17

申请号：US18685153

申请日：2022-08-19

申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： Pil Joong CHUNG ,  Sayuj KOYYAPPURATH ,  Nam-Hai CHUA ,  Rajani SAROJAM ,  Gajendra Pratap SINGH ,  Rajeev J. RAM

IPC分类号： G01N21/65 ,  G01N33/00

CPC分类号： G01N21/65 ,  G01N33/0098

摘要： The present invention relates to the use of Raman spectroscopy for the real time detection and quantitation of innate immunity response in plants. More specifically, the present invention provides Raman spectroscopy as a tool for rapid, non-invasive, and early detection and quantitation of plant innate immune response.

公开(公告)号：US20240338583A1

公开(公告)日：2024-10-10

申请号：US17357270

申请日：2021-06-24

申请人： Massachusetts Institute of Technology

发明人： Martin Zwierlein ,  Thomas Richard Hartke ,  Ningyuan Jia ,  Botond Oreg

IPC分类号： G06N10/40 ,  G01N21/64 ,  G06N10/20 ,  G21K1/00

CPC分类号： G06N10/40 ,  G01N21/6458 ,  G06N10/20 ,  G21K1/003 ,  G21K1/006

摘要： Fermions are the building blocks of matter. Here, we disclose a robust quantum register composed of hundreds of fermionic atom pairs trapped in an optical lattice. With each fermion pair forming a spin-singlet, the qubit is realized as a set of near-degenerate, symmetry-protected two-particle wavefunctions describing common and relative motion. Degeneracy is lifted by the atomic recoil energy, which depends on mass and lattice wavelength, thereby rendering two-fermion motional qubits insensitive to noise of the confining potential. The quantum coherence can last longer than ten seconds. Universal control is provided by modulating interactions between the atoms. Via state-dependent, coherent conversion of free atom pairs into tightly bound molecules, we tune the speed of motional entanglement over three orders of magnitude, yielding 104 Ramsey oscillations within the coherence time. For site-resolved motional state readout, pairs are coherently split into their constituent fermions via a double-well, creating entangled Bell pairs.

公开(公告)号：US12110131B2

公开(公告)日：2024-10-08

申请号：US17591234

申请日：2022-02-02

申请人： Massachusetts Institute of Technology

发明人： Ariel Ekblaw ,  Joseph A. Paradiso

IPC分类号： B64G1/22 ,  G01R33/038

CPC分类号： B64G1/22 ,  G01R33/0385

摘要： A method for autonomously assembling a plurality of tiles is performed in a microgravity environment. Each tile includes a shell having a first geometrical shape and an arrangement of first magnets and a controller that are supported by the shell. The controller controls operation of the arrangement of first magnets to self-assemble the shell with another tile. The first magnets are controlled to mate with a complementary arrangement of second magnets on the other tile when the complementary arrangement of second magnets floats to within a range of magnetic attractive force of the arrangement of first magnets, with or without the aid of propulsion. The controllers in the tiles detect the status of the magnetic bonds to determine whether each pair of tiles is properly bonded or has a magnetic bond error. When an error is detected, the tiles are controlled to disassemble and reassemble to correct the error.

公开(公告)号：US12109301B2

公开(公告)日：2024-10-08

申请号：US18055595

申请日：2022-11-15

申请人： Massachusetts Institute of Technology ,  The General Hospital Corporation

发明人： Xiang Li ,  Michael J. Cima ,  Brian H. Eisner

IPC分类号： A61K9/00 ,  A61K31/4409 ,  A61K31/4422 ,  A61K45/06

CPC分类号： A61K9/0034 ,  A61K9/0002 ,  A61K31/4409 ,  A61K31/4422 ,  A61K45/06

摘要： Provided are formulations and methods for treating one or more genitourinary conditions. The formulations may include a therapeutic agent that includes a calcium channel blocker, a rho kinase inhibitor, or a combination thereof. The methods may include locally administering a therapeutic agent into a ureter. Systems for delivering a therapeutic agent also are provided.