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公开(公告)号:US09126976B2
公开(公告)日:2015-09-08
申请号:US14239452
申请日:2012-08-13
申请人: Rajan Anand , Vincent J. Colandrea , Maud Reiter , Petr Vachal , Aaron Zwicker , Jonathan E. Wilson , Fengqi Zhang , Kake Zhao
发明人: Rajan Anand , Vincent J. Colandrea , Maud Reiter , Petr Vachal , Aaron Zwicker , Jonathan E. Wilson , Fengqi Zhang , Kake Zhao
IPC分类号: A61K31/498 , C07D241/42 , C07D409/06 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06 , A61K31/506 , A61K31/5377 , A61K45/06
CPC分类号: C07D409/06 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D241/42 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06
摘要: Compounds having the structure of Formula Ia, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.
摘要翻译: 具有式Ia结构的化合物,包括化合物的药学上可接受的盐,是CETP抑制剂,可用于培养HDL-胆固醇,降低LDL-胆固醇,以及用于治疗或预防动脉粥样硬化。