公开(公告)号：US20240029818A1

公开(公告)日：2024-01-25

申请号：US18230718

申请日：2023-08-07

申请人： MeMed Diagnostics Ltd.

发明人： Eran EDEN ,  Kfir OVED ,  Roy NAVON ,  Assaf COHEN-DOTAN ,  Olga BOICO

IPC分类号： G16B5/20 ,  G16B5/00 ,  G16B20/00 ,  G16B40/00 ,  G16B20/20 ,  G16B40/30 ,  G16B25/10 ,  G16B40/20 ,  G16H50/50 ,  G06F17/18

CPC分类号： G16B5/20 ,  G16B5/00 ,  G16B20/00 ,  G16B40/00 ,  G16B20/20 ,  G16B40/30 ,  G16B25/10 ,  G16B40/20 ,  G16H50/50 ,  G06F17/18 ,  G16B25/00

摘要： A method of analyzing biological data containing expression values of a plurality of polypeptides in the blood of a subject. The method comprises: calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction. The method further comprises correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection. The coordinate is defined by a combination of the expression values, wherein at least 90% of the segment is between a lower bound line and an upper bound line.

公开(公告)号：US20230184760A1

公开(公告)日：2023-06-15

申请号：US18077277

申请日：2022-12-08

申请人： MeMed Diagnostics Ltd.

发明人： Kfir OVED ,  Eran EDEN ,  Gali KRONENFELD ,  Olga BOICO ,  Roy NAVON ,  Assaf COHEN-DOTAN

IPC分类号： G01N33/569

CPC分类号： G01N33/56911 ,  G01N33/56983 ,  G01N33/56966 ,  G01N2800/26 ,  G01N2800/60

摘要： A method of determining an infection type in a subject is disclosed. The method comprises measuring the concentration of a first determinant selected from the group consisting of the determinants which are set forth in Table 1 and a second determinant selected from the group of the determinants which are set forth in Table 2 in a subject derived sample, wherein the concentration is indicative of the infection type.

公开(公告)号：US10859574B2

公开(公告)日：2020-12-08

申请号：US16157193

申请日：2018-10-11

申请人： MeMed Diagnostics Ltd.

发明人： Kfir Oved ,  Eran Eden

IPC分类号： G01N33/569

摘要： Antibiotics (Abx) are the world's most misused drugs. Antibiotics misuse occurs when the drug is administered in case of a non-bacterial infection (such as a viral infection) for which it is ineffective. Overall, it is estimated that 40-70% of the worldwide Abx courses are mis-prescribed. The financial and health consequences of Abx over-prescription include the direct cost of the drugs, as well as the indirect costs of their side effects, which are estimated at >$15 billion annually. Furthermore, over-prescription directly causes the emergence of Abx-resistant strains of bacteria, which are recognized as one of the major threats to public health today. This generates an immediate need for reliable diagnostics to assist physicians in correct Abx prescription, especially at the point-of-care (POC) where most Abx are prescribed. Accordingly, some aspects of the present invention provide methods using biomarkers for rapidly detecting the source of infection and administrating the appropriate treatment.

公开(公告)号：US20190041388A1

公开(公告)日：2019-02-07

申请号：US16157193

申请日：2018-10-11

申请人： MeMed Diagnostics Ltd.

发明人： Kfir Oved ,  Eran Eden

IPC分类号： G01N33/569

摘要： Antibiotics (Abx) are the world's most misused drugs. Antibiotics misuse occurs when the drug is administered in case of a non-bacterial infection (such as a viral infection) for which it is ineffective. Overall, it is estimated that 40-70% of the worldwide Abx courses are mis-prescribed. The financial and health consequences of Abx over-prescription include the direct cost of the drugs, as well as the indirect costs of their side effects, which are estimated at >$15 billion annually. Furthermore, over-prescription directly causes the emergence of Abx-resistant strains of bacteria, which are recognized as one of the major threats to public health today. This generates an immediate need for reliable diagnostics to assist physicians in correct Abx prescription, especially at the point-of-care (POC) where most Abx are prescribed. Accordingly, some aspects of the present invention provide methods using biomarkers for rapidly detecting the source of infection and administrating the appropriate treatment.

公开(公告)号：US12055545B2

公开(公告)日：2024-08-06

申请号：US17717200

申请日：2022-04-11

申请人： MeMed Diagnostics Ltd.

发明人： Eran Eden ,  Kfir Oved ,  Assaf Cohen-Dotan ,  Roy Navon ,  Olga Boico ,  Meital Paz

IPC分类号： A61P31/04 ,  A61P31/12 ,  G01N33/50 ,  G01N33/535 ,  G01N33/547 ,  G01N33/569 ,  G01N33/68 ,  C07K14/52 ,  C07K14/525 ,  C07K14/54

CPC分类号： G01N33/56944 ,  A61P31/04 ,  A61P31/12 ,  G01N33/50 ,  G01N33/5005 ,  G01N33/535 ,  G01N33/547 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2333/521 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/5753 ,  G01N2333/70578 ,  G01N2333/70596 ,  G01N2333/715 ,  G01N2333/7151 ,  G01N2333/7155 ,  G01N2800/26 ,  G01N2800/60

摘要： Methods of determining infection type are disclosed. In one embodiment, the method comprises measuring the amount of TRAIL and/or IP10 no more than two days from symptom onset.

公开(公告)号：US12044681B2

公开(公告)日：2024-07-23

申请号：US17372575

申请日：2021-07-12

申请人： MeMed Diagnostics Ltd.

发明人： Eran Eden ,  Kfir Oved ,  Assaf Cohen-Dotan ,  Roy Navon ,  Olga Boico ,  Gali Kronenfeld ,  Meital Paz ,  Ellen Bamberger

IPC分类号： C07K16/18 ,  C07K14/525 ,  C07K14/54 ,  C07K14/555 ,  C07K14/575 ,  C07K16/12 ,  C07K16/24 ,  C07K16/26 ,  C07K16/28 ,  G01N33/50 ,  G01N33/52 ,  G01N33/53 ,  G01N33/535 ,  G01N33/543 ,  G01N33/547 ,  G01N33/569 ,  G01N33/577 ,  G01N33/58 ,  G01N33/60 ,  G01N33/68 ,  G16B40/20 ,  G16B40/30 ,  G16B20/00 ,  G16B40/00

CPC分类号： G01N33/56911 ,  C07K14/525 ,  C07K14/5412 ,  C07K14/555 ,  C07K14/57527 ,  C07K16/12 ,  C07K16/18 ,  C07K16/241 ,  C07K16/248 ,  C07K16/249 ,  C07K16/26 ,  C07K16/2818 ,  C07K16/2875 ,  G01N33/5091 ,  G01N33/52 ,  G01N33/53 ,  G01N33/535 ,  G01N33/54306 ,  G01N33/547 ,  G01N33/577 ,  G01N33/581 ,  G01N33/582 ,  G01N33/60 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6893 ,  G16B40/20 ,  G16B40/30 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/555 ,  G01N2333/5753 ,  G01N2333/585 ,  G01N2333/70578 ,  G01N2333/70596 ,  G01N2333/7155 ,  G01N2333/902 ,  G01N2333/916 ,  G01N2469/00 ,  G01N2800/122 ,  G01N2800/26 ,  G16B20/00 ,  G16B40/00

摘要： Methods of diagnosing infections are disclosed. In one embodiment, the method comprises measuring the amount of each of the polypeptides TRAIL, CRP, IP10 and at least one additional polypeptide selected from the group consisting of IL-6 and PCT.

公开(公告)号：US20240157366A1

公开(公告)日：2024-05-16

申请号：US18419606

申请日：2024-01-23

申请人： MeMed Diagnostics Ltd.

发明人： Noga SALOMON ,  Kfir OVED ,  Yana KHALFIN ,  Omer Nahum KATZENELSON ,  Amir GELMAN ,  Moran BROUK RUDICH ,  Roy NAVON ,  Assaf COHEN-DOTAN ,  Eran EDEN ,  Salit TZABAN ,  Arnon ZANGVIL ,  Ofer HALBREICH ,  Matthew FENWICK ,  Adrian Charles Ian SCOTT-MURPHY ,  Matthew Hou-Pou YEUNG ,  James William LUTHER ,  Barbara TORNAGHI ,  Andrea BESANA ,  Thomas Sanelli CRUGNALE

IPC分类号： B01L3/00 ,  G01N35/00 ,  G01N35/10

CPC分类号： B01L3/50853 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/10 ,  A61B5/150022

摘要： In a cartridge device for analyzing a body liquid, a first member of the cartridge has two or more wells for performing assays, and a second member of the cartridge has a compartment for holding one or more disposable pipette tips.

公开(公告)号：US20230045305A1

公开(公告)日：2023-02-09

申请号：US17955599

申请日：2022-09-29

申请人： MeMed Diagnostics Ltd.

发明人： Kfir OVED ,  Eran EDEN ,  Olga BOICO ,  Gali KRONENFELD ,  Roy NAVON ,  Assaf COHEN-DOTAN ,  Einav SIMON

IPC分类号： C12Q1/70 ,  C12Q1/689 ,  G01N33/569 ,  C12Q1/00

摘要： Methods of determining infection type are disclosed. In one embodiment, the method comprises measuring the amount of a determinant which is set forth in Tables 1 or 2 in a sample derived from the subject, wherein said amount is indicative of the infection type.

公开(公告)号：US20220326256A1

公开(公告)日：2022-10-13

申请号：US17841704

申请日：2022-06-16

申请人： MeMed Diagnostics Ltd.

发明人： Eran EDEN ,  Kfir OVED ,  Assaf COHEN-DOTAN ,  Roy NAVON ,  Olga BOICO ,  Meital PAZ

IPC分类号： G01N33/68 ,  G16H50/30 ,  G16H50/70 ,  G16H50/20 ,  G01N33/50 ,  G01N33/52 ,  G01N33/53 ,  G01N33/60 ,  G01N33/58

摘要： A method of determining a management course for treating a subject showing symptoms of a disease is disclosed. The method comprises measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is below a predetermined amount, the subject is treated as a high-risk patient.

公开(公告)号：US11353456B2

公开(公告)日：2022-06-07

申请号：US16336528

申请日：2017-09-27

申请人： MeMed Diagnostics Ltd.

发明人： Kfir Oved ,  Eran Eden ,  Assaf Cohen-Dotan ,  Roy Navon ,  Niv Steven Mastboim ,  Olga Boico ,  Meital Paz

IPC分类号： A61B17/00 ,  G01N15/14 ,  G01N33/58 ,  G01N33/60 ,  G01N33/569 ,  G01N33/68 ,  G16H50/20 ,  C07K14/525

摘要： A method of measuring risk assessment in a patient with appendicitis is disclosed. The method comprises: (a) measuring the TRAIL protein level in a blood sample of the patient; (b) providing a risk assessment based on the TRAIL protein level.