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1.
公开(公告)号:US09174978B2
公开(公告)日:2015-11-03
申请号:US14665245
申请日:2015-03-23
申请人: Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu
发明人: Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu
IPC分类号: A61K31/40 , C07D417/14 , A61K31/427 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/496 , A61K31/4545 , C07D487/04 , A61K45/06
CPC分类号: A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , C07D487/04 , Y02A50/473 , Y02A50/481
摘要: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
摘要翻译: 本发明一般涉及本文进一步描述的式I抗菌化合物及其药学上可接受的盐和制剂。 在某些方面,本发明涉及使用这些化合物治疗诸如革兰氏阴性菌引起的感染的方法。
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公开(公告)号:US20160051523A1
公开(公告)日:2016-02-25
申请号:US14861797
申请日:2015-09-22
申请人: Virender Singh AULAKH , Anthony CASAREZ , Xiaodong LIN , Mika LINDVALL , Glenn MCENROE , Heinz Ernst MOSER , Folkert RECK , Meiliana TJANDRA , Robert Lowell SIMMONS , Aregahegn YIFRU , Qingming ZHU
发明人: Virender Singh AULAKH , Anthony CASAREZ , Xiaodong LIN , Mika LINDVALL , Glenn MCENROE , Heinz Ernst MOSER , Folkert RECK , Meiliana TJANDRA , Robert Lowell SIMMONS , Aregahegn YIFRU , Qingming ZHU
IPC分类号: A61K31/427 , A61K45/06 , A61K31/496 , A61K31/454 , A61K31/4439
CPC分类号: A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , C07D487/04 , Y02A50/473 , Y02A50/481
摘要: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
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公开(公告)号:US20140134132A1
公开(公告)日:2014-05-15
申请号:US14037644
申请日:2013-09-26
申请人: Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人: Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译: 本发明提供式I化合物; 或其药学上可接受的盐,其中本文定义的变量R1,R2,R3,R4,R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂,因此可用于预防或治疗疾病或 疾病如HCV感染,中风,多发性硬化,HBV感染,HPV感染,哮喘,癌症,肌营养不良,败血症,缺血/再灌注损伤和心力衰竭。
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公开(公告)号:US20150306172A1
公开(公告)日:2015-10-29
申请号:US14717872
申请日:2015-05-20
申请人: Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人: Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译: 本发明提供式I化合物; 或其药学上可接受的盐,其中R1,R2,R3,R4,R5和AB如本文所定义,其为非免疫抑制性,亲环蛋白结合,mPTP阻断剂,因此可用于预防或治疗疾病或病症 例如HCV感染,中风,多发性硬化,HBV感染,HPV感染,哮喘,癌症,肌营养不良,败血症,缺血/再灌注损伤和心力衰竭。
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5.
公开(公告)号:US20150266867A1
公开(公告)日:2015-09-24
申请号:US14665245
申请日:2015-03-23
申请人: Virender Singh AULAKH , Anthony CASAREZ , Xiaodong LIN , Mika LINDVALL , Glenn MCENROE , Heinz Ernst MOSER , Folkert RECK , Meiliana TJANDRA , Robert Lowell SIMMONS , Aregahegn YIFRU , Qingming ZHU
发明人: Virender Singh AULAKH , Anthony CASAREZ , Xiaodong LIN , Mika LINDVALL , Glenn MCENROE , Heinz Ernst MOSER , Folkert RECK , Meiliana TJANDRA , Robert Lowell SIMMONS , Aregahegn YIFRU , Qingming ZHU
IPC分类号: C07D417/14 , A61K31/454 , A61K31/4439 , A61K45/06 , A61K31/496 , A61K31/4545 , C07D487/04 , A61K31/427 , A61K31/433
CPC分类号: A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , C07D487/04 , Y02A50/473 , Y02A50/481
摘要: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
摘要翻译: 本发明一般涉及本文进一步描述的式I抗菌化合物及其药学上可接受的盐和制剂。 在某些方面,本发明涉及使用这些化合物治疗诸如革兰氏阴性菌引起的感染的方法。
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公开(公告)号:US09072696B2
公开(公告)日:2015-07-07
申请号:US14037644
申请日:2013-09-26
申请人: Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人: Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译: 本发明提供式I化合物; 或其药学上可接受的盐,其中本文定义的变量R1,R2,R3,R4,R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂,因此可用于预防或治疗疾病或 疾病如HCV感染,中风,多发性硬化,HBV感染,HPV感染,哮喘,癌症,肌营养不良,败血症,缺血/再灌注损伤和心力衰竭。
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