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公开(公告)号:US07737160B2
公开(公告)日:2010-06-15
申请号:US11675183
申请日:2007-02-15
申请人: Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人: Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号: A61K31/4745 , A61K31/4743 , A61K31/4741
CPC分类号: A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法,含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号:US08273736B2
公开(公告)日:2012-09-25
申请号:US12623026
申请日:2009-11-20
申请人: Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人: Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号: A61K31/4365 , A61K31/55 , A61K31/5377 , A61K31/496 , C07D495/04
CPC分类号: A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法,含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号:US07202363B2
公开(公告)日:2007-04-10
申请号:US10899168
申请日:2004-07-26
申请人: Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人: Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号: C07D491/04 , C07D421/04
CPC分类号: A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有式的化合物
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公开(公告)号:US07468371B2
公开(公告)日:2008-12-23
申请号:US11089473
申请日:2005-03-24
申请人: Lee D. Arnold , Jürgen Dinges , Richard W. Dixon , Stevan W. Djuric , Anna M. Ericsson , Kimba Fischer , Alan F. Gasiecki , Vijaya J. Gracias , James H. Holms , Makoto Takeshita , Michael R. Michaelides , Melanie A. Muckey , Paul Rafferty , Douglas H. Steinman , Carol K. Wada , Zhiren Xia , Irini Akritopoulou-Zanze , Henry Q. Zhang
发明人: Lee D. Arnold , Jürgen Dinges , Richard W. Dixon , Stevan W. Djuric , Anna M. Ericsson , Kimba Fischer , Alan F. Gasiecki , Vijaya J. Gracias , James H. Holms , Makoto Takeshita , Michael R. Michaelides , Melanie A. Muckey , Paul Rafferty , Douglas H. Steinman , Carol K. Wada , Zhiren Xia , Irini Akritopoulou-Zanze , Henry Q. Zhang
IPC分类号: A61K31/496 , A61K31/415 , C07D231/54 , C07D409/14
CPC分类号: C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
摘要: Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 本发明的化合物可用于抑制蛋白酪氨酸激酶。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US20100069371A1
公开(公告)日:2010-03-18
申请号:US12623026
申请日:2009-11-20
申请人: Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人: Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号: A61K31/4365 , C07D495/04 , A61K31/55 , A61K31/5377 , A61K31/496
CPC分类号: A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法,含有该化合物的组合物和使用该化合物的处理方法。
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