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    Molecular differences between species of the M. tuberculosis complex
    1.
    发明授权
    Molecular differences between species of the M. tuberculosis complex 有权
    结核分枝杆菌菌种之间的分子差异

    公开(公告)号：US07700118B2

    公开(公告)日：2010-04-20

    申请号：US12049063

    申请日：2008-03-14

    申请人： Marcel Behr ,  Peter Small ,  Gary Schoolnik ,  Michael A. Wilson

    发明人： Marcel Behr ,  Peter Small ,  Gary Schoolnik ,  Michael A. Wilson

    IPC分类号： A61K39/04 ,  A61K39/205 ,  A61K39/00

    CPC分类号： C12Q1/689 ,  C12Q2600/156

    摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tubercuosis to attenuate the pathogenic bacteria.

    摘要翻译： 在分枝杆菌分离株中鉴定了特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.tb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。

    Gas generation system
    2.
    发明授权
    Gas generation system 失效
    气体发生系统

    公开(公告)号：US07188567B1

    公开(公告)日：2007-03-13

    申请号：US10130191

    申请日：2000-11-10

    申请人： John R. Italiane ,  James M. Styner ,  Andrew C. Nguyen ,  Gary S. Gregg ,  Gary F. Holland ,  Michael A. Wilson

    发明人： John R. Italiane ,  James M. Styner ,  Andrew C. Nguyen ,  Gary S. Gregg ,  Gary F. Holland ,  Michael A. Wilson

    IPC分类号： C06D5/00

    CPC分类号： C06D5/06 ,  B60R21/264 ,  B60R2021/2633

    摘要： A gas generator (24; 140) may be used in an inflatable member system (20) which includes an inflatable member (22) expandable from a stowed condition to a deployed condition. The generator may include a flexible container (30; 150) within the inflatable member, a gas generant (28; 148), initially located within the flexible container, and an initiator (34). A propagating member (60; 142) may be located within the container to permit the initiator to initiate the generant upon triggering of the initiator to inflate the inflatable member from stowed to deployed conditions. A sustainer (44; 152; 156) may be provided to sustain the gas generation and may be positioned within a generator housing upstream of the propagating member or at or adjacent the downstream end of the propagating member.

    摘要翻译： 气体发生器（24; 140）可以用在可膨胀构件系统（20）中，该系统包括从收起状态扩展到展开状态的可膨胀构件（22）。 发生器可以包括可充气构件内的柔性容器（30; 150），最初位于柔性容器内的气体发生剂（28; 148）和起动器（34）。 传播构件（60; 142）可以位于容器内，以允许引发器在触发引发器时起动发生器，以使可充气构件从收起的状态充满到展开状态。 可以提供维持器（44; 152; 156）以维持气体产生并且可以位于传播构件上游的发生器壳体内，或位于传播构件的下游端处或邻近传播构件的下游端。

    Molecular differences between species of the M. tuberculosis complex
    3.
    发明授权
    Molecular differences between species of the M. tuberculosis complex 失效
    结核分枝杆菌菌种之间的分子差异

    公开(公告)号：US06291190B1

    公开(公告)日：2001-09-18

    申请号：US09318191

    申请日：1999-05-25

    申请人： Marcel Behr ,  Peter Small ,  Gary Schoolnik ,  Michael A. Wilson

    发明人： Marcel Behr ,  Peter Small ,  Gary Schoolnik ,  Michael A. Wilson

    IPC分类号： G01N3353

    CPC分类号： C12Q1/689 ,  C12Q2600/156

    摘要： Specific genetic deletions are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tuberculosis to attenuate the pathogenic bacteria.

    摘要翻译： 在分枝杆菌分离物中鉴定特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.bb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。

    Threshold crossover detector with improved digital noise rejection
    4.
    发明授权
    Threshold crossover detector with improved digital noise rejection 失效
    具有改进的数字噪声抑制的阈值交叉检测器

    公开(公告)号：US5278462A

    公开(公告)日：1994-01-11

    申请号：US873253

    申请日：1992-04-24

    申请人： Michael A. Wilson

    发明人： Michael A. Wilson

    IPC分类号： H03K5/08 ,  H03K5/1536 ,  H03K5/153

    CPC分类号： H03K5/08 ,  H03K5/1536

    摘要： The detector applies an analog input signal through respectively positive and negative offset voltages to the inputs of two comparators, one of which produces a first output signal as the input signal passes beyond a predetermined minimum voltage in the positive going direction, and the other of which produces a second output signal when the input voltage exceeds a minimum predetermined value in a negative going direction. The input signal is also applied directly to the input of a third comparator the output of which produces a third signal each time the input signal crosses over zero voltage in a positive going direction. The first and second comparator output signals are applied to the reset and set terminals, respectively, of a first flip flop. The output of this first flip flop, and the output of the third comparator are applied through an AND gate to the set terminal of a second flip flop. The second flip flop produces at its output a digital signal precisely at the time that a signal is produced at the output of the third comparator, provided the outputs of the first and second comparators have been successively generated in the cycle of the input voltage immediately preceding the output signal of the third comparator.

    摘要翻译： 检测器通过分别的正和负偏移电压将模拟输入信号施加到两个比较器的输入端，其中一个输入信号随着输入信号在正向上超过预定最小电压而产生第一输出信号，另一个 当输入电压在负方向上超过最小预定值时产生第二输出信号。 输入信号也直接施加到第三比较器的输入，第三比较器的输出在每次输入信号在正向运行方向上跨过零电压时产生第三信号。 第一和第二比较器输出信号分别施加到第一触发器的复位和设置端子。 该第一触发器的输出和第三比较器的输出通过与门施加到第二触发器的设定端。 第二触发器在其输出处产生数字信号，在第三比较器的输出处产生信号时，只要第一和第二比较器的输出在紧接着的输入电压的周期中连续生成 第三比较器的输出信号。

    Golf grip cover
    6.
    发明授权
    Golf grip cover 有权
    高尔夫手柄盖

    公开(公告)号：US07886787B1

    公开(公告)日：2011-02-15

    申请号：US12283518

    申请日：2008-09-12

    申请人： Michael A. Wilson

    发明人： Michael A. Wilson

    IPC分类号： A63B57/00 ,  A63B53/00

    CPC分类号： A63B60/36 ,  A63B53/14 ,  A63B57/00

    摘要： A cover for the grip area of golf clubs to keep them dry and protected from the elements is herein disclosed, preferably comprising a neoprene covering in the shape of a tube with the approximate dimensions of twelve (12) to twenty (20) inches long and a diameter of two (2) inches. A first end of the tube is sealed, while a second end is furnished with a flexible membrane which seals it against the club shaft. The closed end is provided with a hook to allow the cover to be hung along with a club, thereby providing a means for the cover to be placed over the grip end of a golf club in much the same manner as a sock. This not only extends the life of the club and grip, but provides the golfer with enhanced performance due to the decreased risk of slippage during play, particularly during wet conditions.

    摘要翻译： 本文公开了用于保持其干燥和保护元件的高尔夫球杆的握持区域的盖，优选地包括具有十二（12）至二十（20）英寸长的尺寸的管的形状的氯丁橡胶覆盖物，并且 直径为2（2）英寸。 管的第一端被密封，而第二端设置有柔性膜，其将其密封抵靠球杆杆杆。 封闭端设置有钩子，以允许盖子与杆杆一起悬挂，从而提供了一种用于以与袜子大致相同的方式将盖子放置在高尔夫球杆的握持端上的装置。 这不仅延长了球杆的使用寿命，而且提高了高尔夫球手的性能，因为在打滑期间打滑的风险降低，特别是在潮湿条件下。

    Thrust slot air conveyor
    8.
    发明授权
    Thrust slot air conveyor 失效
    推力槽空气输送机

    公开(公告)号：US5820306A

    公开(公告)日：1998-10-13

    申请号：US828760

    申请日：1997-04-01

    申请人： Brian K. Hilbish ,  Michael A. Wilson

    发明人： Brian K. Hilbish ,  Michael A. Wilson

    IPC分类号： B65G51/03 ,  B65G51/02

    CPC分类号： B65G51/035 ,  B65G2201/0244 ,  B65G2201/0247

    摘要： An air conveyor which includes guides for stabilizing articles during conveyance and a plenum with apertures for providing pressurized air is provided. In the preferred embodiment, the air conveyor also includes opposed spacers defining passages having a closed end and an open end. The passages are in fluid communication with the apertures of the plenum for directing streams of pressurized air through the open ends at the articles in a downstream direction to propel the articles. In another embodiment, channels defined in support structure for the guides form part of passageways for directing streams of pressurized air at an inclined and downstream angle to propel the articles. The guides are removable to allow the conveyor to be adapted to different sized and shaped articles. The air conveyor may also include an additional plenum and additional opposed spacers associated with the plenum for propelling the articles downstream.

    摘要翻译： 提供一种空气输送机，其包括用于在运输期间稳定物品的引导件和具有用于提供加压空气的孔的增压室。 在优选实施例中，空气输送机还包括限定具有封闭端和开口端的通道的相对间隔件。 通道与增压室的孔流体连通，用于在下游方向上引导加压空气流通过物品处的开口端，以推进物品。 在另一个实施例中，限定在用于引导件的支撑结构中的通道形成用于以倾斜和下游角度引导加压空气流的通道的一部分，以推进物品。 引导件是可拆卸的，以允许输送机适应不同尺寸和成形的物品。 空气输送机还可以包括附加的增压室和与增压室相关联的附加的相对间隔件，用于将物品推进下游。

    Linear oscillator for proximity sensor
    9.
    发明授权
    Linear oscillator for proximity sensor 失效
    接近传感器用线性振荡器

    公开(公告)号：US4068189A

    公开(公告)日：1978-01-10

    申请号：US730532

    申请日：1976-10-07

    申请人： Michael A. Wilson

    发明人： Michael A. Wilson

    IPC分类号： G01V3/10 ,  H03K17/95 ,  G01R33/12 ,  G08C21/00

    CPC分类号： G01V3/102 ,  H03K17/9537 ,  H03K17/9547

    摘要： A linear oscillator circuit has a resonant circuit which develops an oscillating voltage V.sub.R having an amplitude proportional to a distance between a conducting body and the resonant circuit located within a probe. A control power drive circuit coupled to the output of the resonant circuit switches a current through the resonant circuit during each period of oscillation of the voltage V.sub.R. A reference current source is coupled to the control power drive circuit for drawing a current through the control power drive circuit and the resonant circuit. The magnitude of the current is equal to the magnitude of an independently established reference current. A detector circuit responsive to the value of the amplitude of oscillation may be provided to indicate the distance of the conductive body from the resonant circuit-containing probe.

    ULTRASONIC FLOW METER
    10.
    发明申请
    ULTRASONIC FLOW METER 审中-公开
    超声波流量计

    公开(公告)号：US20120271569A1

    公开(公告)日：2012-10-25

    申请号：US13404681

    申请日：2012-02-24

    申请人： Michael A. Wilson

    发明人： Michael A. Wilson

    IPC分类号： G06F19/00 ,  G06F15/00

    CPC分类号： G01F1/66 ,  G01F15/022

    摘要： A method and apparatus for measuring fluid flow in a conduit using ultrasonic transducers. A periodic signal is transmitted from a first transducer and received at a second transducer, and from the second transducer to the first. For each transmission, the phase difference between the signal as transmitted and received is measured. The rate of fluid flow in the conduit can be computed from the phase relationships of the transmitted and received signals.

    摘要翻译： 一种使用超声换能器测量导管中的流体流动的方法和装置。 周期性信号从第一换能器发送并在第二换能器处接收，并且从第二换能器传送到第一换能器。 对于每次发送，测量发送和接收的信号之间的相位差。 可以根据发送和接收信号的相位关系来计算导管中的流体流量。