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    Methods and compositions for treatment of ion imbalances
    1.
    发明申请
    Methods and compositions for treatment of ion imbalances 有权
    用于治疗离子失衡的方法和组合物

    公开(公告)号：US20050220750A1

    公开(公告)日：2005-10-06

    申请号：US10814527

    申请日：2004-03-30

    Applicant: Alpern Robert ,  Jerry Buysse ,  Han Chang ,  Dominique Charmot ,  Michael Cope ,  John Fordtran ,  Gerrit Klaerner

    Inventor： Alpern Robert ,  Jerry Buysse ,  Han Chang ,  Dominique Charmot ,  Michael Cope ,  John Fordtran ,  Gerrit Klaerner

    IPC: A61K31/74 ,  A61K31/785

    CPC classification number: A61K31/74

    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.

    Abstract translation: 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。

    Toxin binding compositions
    3.
    发明申请
    Toxin binding compositions 审中-公开
    毒素结合组合物

    公开(公告)号：US20060078534A1

    公开(公告)日：2006-04-13

    申请号：US10965688

    申请日：2004-10-13

    Applicant: Dominique Charmot ,  Jerry Buysse ,  Han Chang ,  Tony Mong ,  Michael Cope ,  Elizabeth Goka

    Inventor： Dominique Charmot ,  Jerry Buysse ,  Han Chang ,  Tony Mong ,  Michael Cope ,  Elizabeth Goka

    IPC: A61K31/765 ,  C08G63/91

    CPC classification number: A61K31/765 ,  A61K47/549 ,  A61K47/58 ,  A61K47/6927 ,  C08F293/005 ,  C08L2201/50

    Abstract: Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the invention can be used in the treatment of toxin-mediated diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, including Clostridium difficile associated diarrhea.

    Abstract translation: 本文提供了用于治疗毒素介导的疾病的方法和组合物。 本发明的一个方面是与毒素相互作用的基于寡糖的治疗剂及其使用方法。 在一个实施方案中，本发明的基于寡糖的治疗剂包含具有连接的寡糖结合部分的聚合物颗粒。 本发明的组合物可用于治疗毒素介导的疾病，例如抗生素相关性腹泻和假膜性结肠炎，包括艰难梭菌相关性腹泻。

    Apparatuses and Methods for Evaluating and Sorting Pollen and Plants
    6.
    发明申请
    Apparatuses and Methods for Evaluating and Sorting Pollen and Plants 审中-公开
    花粉和植物评估和排序的设备和方法

    公开(公告)号：US20140115730A1

    公开(公告)日：2014-04-24

    申请号：US14006605

    申请日：2012-03-20

    Applicant: Jason Michael Cope

    Inventor： Jason Michael Cope

    IPC: A01H1/04 ,  A01H1/02 ,  G01N33/569 ,  C12Q1/68

    CPC classification number: A01H1/04 ,  A01H1/02 ,  C12Q1/6895 ,  G01N33/56961

    Abstract: A method for sorting pollen containing genetic elements of interest may include associating a genetic marker with seeds defining the genetic elements of interest, growing plants from the seeds, collecting pollen from the seeds, evaluating the pollen for presence of the genetic markers, and sorting the pollen based on presence or absence of the genetic markers. A method of determining viability of pollen may evaluate the optical density of grains of pollen and compare the optical density to an optical density threshold. Further, a method for identifying plants defining a genetic marker with seeds defining the genetic element of interest, growing plants from the seeds, and evaluating the plants for presence of the genetic marker. Additionally, a method for identifying a genotype of pollen may include evaluating pollen via spectral and/or hyperspectral imaging,

    Abstract translation: 用于分选含有感兴趣的遗传元件的花粉的方法可以包括将遗传标记物与限定感兴趣的遗传元件的种子，从种子生长的植物，从种子收集花粉，评估花粉存在遗传标记物，以及分类 基于存在或不存在遗传标记的花粉。 确定花粉生存力的方法可以评估花粉颗粒的光密度，并将光密度与光密度阈值进行比较。 此外，一种用于鉴定用定义感兴趣的遗传元件的种子定义遗传标记的植物的方法，从种子生长植物，以及评估植物存在遗传标记。 另外，用于鉴定花粉基因型的方法可以包括通过光谱和/或高光谱成像评价花粉，

    HFC SOLUTION FORMULATIONS CONTAINING SALBUTAMOL HYDROCHLORIDE OR SALBUTAMOL CITRATE
    8.
    发明申请
    HFC SOLUTION FORMULATIONS CONTAINING SALBUTAMOL HYDROCHLORIDE OR SALBUTAMOL CITRATE 审中-公开
    含有盐酸氢氯化物或沙丁胺醇柠檬酸盐的HFC溶液制剂

    公开(公告)号：US20070041911A1

    公开(公告)日：2007-02-22

    申请号：US11463477

    申请日：2006-08-09

    Applicant: Friedrich Schmidt ,  Mariola Mann ,  Michael Cope ,  Holger Memmesheimer

    Inventor： Friedrich Schmidt ,  Mariola Mann ,  Michael Cope ,  Holger Memmesheimer

    IPC: A61L9/04 ,  A61K31/573 ,  A61K31/137 ,  A61K31/4745

    CPC classification number: C07C215/60 ,  A61K9/008 ,  A61K31/137 ,  C07C59/265

    Abstract: This invention relates to stabilized aerosol solution formulations containing acid addition salts of salbutamol, which are suitable for administration by metered dose inhalers (MDIs). More particularly, this invention relates to solution formulations containing one of the aforementioned salts of salbutamol, preferably salbutamol hydrochloride or salbutamol citrate, more preferably one of the two before mentioned salts in combination with one or more additional pharmacologically active substances, together with an environmentally safe hydrofluorocarbon (HFC) as a propellant, a co-solvent, preferably an organic compound as a co-solvent, and either an inorganic acid or an organic acid.

    Abstract translation: 本发明涉及含有沙丁胺醇酸加成盐的稳定化气溶胶制剂，其适用于计量吸入器（MDI）的给药。 更具体地说，本发明涉及含有上述沙丁胺醇盐之一，优选盐酸沙丁胺醇或沙丁胺醇柠檬酸盐的溶液制剂，更优选两种上述盐中的一种与一种或多种另外的药理学活性物质组合，以及环境安全 作为推进剂的氢氟烃（HFC），共溶剂，优选作为助溶剂的有机化合物，以及无机酸或有机酸。

    Apparatus and Method for Dispensing Grains of Pollen
    10.
    发明申请
    Apparatus and Method for Dispensing Grains of Pollen 审中-公开
    花粉分配装置及方法

    公开(公告)号：US20140223812A1

    公开(公告)日：2014-08-14

    申请号：US14006715

    申请日：2012-03-20

    Applicant: Jason Michael Cope ,  Bradley Thomas McAvoy

    Inventor： Jason Michael Cope ,  Bradley Thomas McAvoy

    IPC: A01H1/02

    CPC classification number: A01H1/025 ,  A01H1/02

    Abstract: An apparatus configured for dispensing grains of pollen may include a pollen storage container, a flow source configured to dispense the grains of pollen from the pollen storage container, and a control mechanism configured to selectively activate the flow source. The apparatus may or may not apply an electrical charge to the grains of pollen. Related methods may include steps of collecting pollen, inserting the pollen into a pollen storage container, connecting the pollen storage container to a dispensing device such as the above-described apparatus, and dispensing the pollen from the pollen storage container with the dispensing device. Known grains of pollen may be dispensed to create predetermined gamete crosses with known plants. Further, an outlet of a fan which dispenses the pollen from the pollen storage container or other parts of the dispensing device may be cleaned when swapping the pollen storage container to prevent cross-contamination.

    Abstract translation: 配置用于分配花粉颗粒的装置可以包括花粉储存容器，被配置为从花粉储存容器分配花粉颗粒的流动源和被配置为选择性地激活流动源的控制机构。 该设备可以或可以不向花粉颗粒施加电荷。 相关方法可以包括收集花粉，将花粉插入花粉储存容器，将花粉储存容器连接到诸如上述装置的分配装置的步骤，以及使用分配装置从花粉储存容器分配花粉。 可以分配已知的花粉粒以产生与已知植物的预定的配子交叉。 此外，当交换花粉储存容器以防止交叉污染时，可以清洁从花粉储存容器或分配装置的其它部分分配花粉的风扇的出口。

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