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公开(公告)号:US06329400B1
公开(公告)日:2001-12-11
申请号:US09382924
申请日:1999-08-25
申请人: Robert Carl Andrews , Marc Werner Andersen , Dulce Garrido Bubacz , Joseph Howing Chan , David John Cowan , Michael David Gaul , Daryl Lynn McDougald , David Lee Musso , Michael Howard Rabinowitz , Jennifer Badiang Stanford , Robert William Wiethe
发明人: Robert Carl Andrews , Marc Werner Andersen , Dulce Garrido Bubacz , Joseph Howing Chan , David John Cowan , Michael David Gaul , Daryl Lynn McDougald , David Lee Musso , Michael Howard Rabinowitz , Jennifer Badiang Stanford , Robert William Wiethe
IPC分类号: C07D40912
CPC分类号: C07D213/75 , C07D277/46 , C07D285/135 , C07D409/12 , C07D417/12
摘要: A family of compounds having the general structural formula where W is a reverse hydroxamic acid group, and R1, R2, R3, R4, R5 and R6 are as described in the specification, or a pharmaceutically acceptable salt, solvate, biohydrolyzable ester, biohydrolyzable amide, affinity reagent, or prodrug thereof.
摘要翻译: 具有通式结构式W的化合物族是反向异羟肟酸基团,R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述,或其药学上可接受的盐,溶剂化物,生物可水解的酯,可生物水解的酰胺, 亲和试剂或其前药。
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公开(公告)号:US07189851B2
公开(公告)日:2007-03-13
申请号:US10507006
申请日:2003-02-24
申请人: Ashok Bhandari , Eric Eugene Boros , David John Cowan , Anthony Louis Handlon , Clifton Earl Hyman , Jeffrey Alan Oplinger , Michael Howard Rabinowitz , Philip Stewart Turnbull
发明人: Ashok Bhandari , Eric Eugene Boros , David John Cowan , Anthony Louis Handlon , Clifton Earl Hyman , Jeffrey Alan Oplinger , Michael Howard Rabinowitz , Philip Stewart Turnbull
IPC分类号: C07D471/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号: C07D471/14 , C07D487/04
摘要: The present invention relates to novel fused heterocyclic ring system compounds and methods for their use in the treatment and prevention of diseases or conditions.
摘要翻译: 本发明涉及新颖的稠合杂环体系化合物及其用于治疗和预防疾病或病症的方法。
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公开(公告)号:US06191150B1
公开(公告)日:2001-02-20
申请号:US09382747
申请日:1999-08-25
申请人: Robert Carl Andrews , Marc Werner Andersen , Dulce Garrido Bubacz , Joseph Howing Chan , David John Cowan , Michael David Gaul , Daryl Lynn McDougald , David Lee Musso , Michael Howard Rabinowitz , Jennifer Badiang Stanford , Robert William Wiethe
发明人: Robert Carl Andrews , Marc Werner Andersen , Dulce Garrido Bubacz , Joseph Howing Chan , David John Cowan , Michael David Gaul , Daryl Lynn McDougald , David Lee Musso , Michael Howard Rabinowitz , Jennifer Badiang Stanford , Robert William Wiethe
IPC分类号: A61K3144
CPC分类号: C07D277/46
摘要: A family of compounds having the general structural formula where W is a reverse hydroxamic acid group, and R1, R2, R3, R4, R5 and R6 are as described in the specification, or a pharmaceutically acceptable salt, solvate, biohydrolyzable ester, biohydrolyzable amide, affinity reagent, or prodrug thereof.
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公开(公告)号:US06172064B2
公开(公告)日:2001-01-09
申请号:US09382333
申请日:1999-08-25
申请人: Robert Carl Andrews , Marc Werner Andersen , David John Cowan , David Norman Deaton , Scott Howard Dickerson , David Harold Drewry , Michael David Gaul , Michael Joseph Luzzio , Brian Edward Marron , Michael Howard Rabinowitz
发明人: Robert Carl Andrews , Marc Werner Andersen , David John Cowan , David Norman Deaton , Scott Howard Dickerson , David Harold Drewry , Michael David Gaul , Michael Joseph Luzzio , Brian Edward Marron , Michael Howard Rabinowitz
IPC分类号: C07D21170
CPC分类号: C07D213/40 , C07C259/06 , C07D295/13 , C07D333/24
摘要: A family of compounds having the general structural formula where W is a reverse hydroxamic acid group, and R1, R2, R3, R4, R5 and R6 are as described in the specification, or a pharmaceutically acceptable salt, solvate, biohydrolyzable ester, biohydrolyzable amide, affinity reagent, or prodrug thereof. Also described are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine.
摘要翻译: 具有通式结构式W的化合物族是反向异羟肟酸基团,R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述,或其药学上可接受的盐,溶剂化物,生物可水解的酯,可生物水解的酰胺, 亲和试剂或其前药。 还描述了它们的制备方法,包括这些化合物的药物组合物及其在药物中的用途。
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