-
公开(公告)号：US08247565B2
公开(公告)日：2012-08-21
申请号：US12891667
申请日：2010-09-27
申请人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
IPC分类号： C07D417/00 , A61K31/44
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
-
公开(公告)号：US20090012080A1
公开(公告)日：2009-01-08
申请号：US12214804
申请日：2008-06-20
申请人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
IPC分类号： A61K31/5377 , C07D417/14 , A61K31/4439 , A61P3/00 , C07D413/14
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
-
3.发明授权Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier 失效用于扫描盘形数据载体的装置，包括用于传送数据载体的传送系统公开(公告)号：US07367033B2
公开(公告)日：2008-04-29
申请号：US10562883
申请日：2004-06-28
CPC分类号： G11B17/056
摘要： Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier. In the case of a device (1) for scanning a disc-shaped data carrier (2), with a pivotable data carrier plate (4), which features a receptacle for the data carrier (2), said data carrier (2) is to be able to be moved between the inlay position and the scanning position, which is at a higher level than the inlay position, by means of a combined sliding and swivel action, in order to minimize the design height of the device (1) with an adjustably held transport system (5) for moving the data carrier (2) between an inlay position and a scanning position, in which scanning position the data carrier (2) is located on the data carrier plate (4) for scanning, and with a guide device, such as a lever (9) or sliding blocks (17, 18).
摘要翻译： 用于扫描盘形数据载体的装置，包括用于传送数据载体的传送系统。 在用于扫描盘形数据载体（2）的装置（1）的情况下，具有用于数据载体（2）的容器的可枢转数据载体板（4），所述数据载体（2）是 能够通过组合的滑动和旋转动作在嵌入位置和位于比镶嵌位置更高的扫描位置之间移动，以便最小化装置（1）的设计高度与 可移动地保持的传送系统（5），用于在数据载体（2）位于数据载体板（4）上用于扫描的扫描位置和扫描位置之间移动数据载体（2） 引导装置，例如杠杆（9）或滑块（17,18）。
-
公开(公告)号：US07829556B2
公开(公告)日：2010-11-09
申请号：US12214804
申请日：2008-06-20
申请人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
IPC分类号： A61K31/535 , C07D413/00
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
-
5.发明申请Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier 失效用于扫描盘形数据载体的装置，包括用于传送数据载体的传送系统公开(公告)号：US20060184952A1
公开(公告)日：2006-08-17
申请号：US10562883
申请日：2004-06-28
申请人： Michael Jirousek , Ho Koh , Gottfried Hack , Friedrich Rastelli
发明人： Michael Jirousek , Ho Koh , Gottfried Hack , Friedrich Rastelli
IPC分类号： G11B17/04
CPC分类号： G11B17/056
摘要： Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier. In the case of a device (1) for scanning a disc-shaped data carrier (2), with a pivotable data carrier plate (4), which features a receptacle for the data carrier (2), said data carrier (2) is to be able to be moved between the inlay position and the scanning position, which is at a higher level than the inlay position, by means of a combined sliding and swivel action, in order to minimize the design height of the device (1) with an adjustably held transport system (5) for moving the data carrier (2) between an inlay position and a scanning position, in which scanning position the data carrier (2) is located on the data carrier plate (4) for scanning, and with a guide device, such as a lever (9) or sliding blocks (17, 18).
摘要翻译： 用于扫描盘形数据载体的装置，包括用于传送数据载体的传送系统。 在用于扫描盘形数据载体（2）的装置（1）的情况下，具有用于数据载体（2）的容器的可枢转数据载体板（4），所述数据载体（2）是 能够通过组合的滑动和旋转动作在嵌入位置和位于比镶嵌位置更高的扫描位置之间移动，以便最小化装置（1）的设计高度与 可移动地保持的传送系统（5），用于在数据载体（2）位于数据载体板（4）上用于扫描的扫描位置和扫描位置之间移动数据载体（2） 引导装置，例如杠杆（9）或滑块（17,18）。
-
公开(公告)号：US20110113498A1
公开(公告)日：2011-05-12
申请号：US12992765
申请日：2009-05-15
CPC分类号： C07K14/4702 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： Provided herein are Sirt1 polymorphic variants having a substitution at amino acid residue 107 or nucleotide 373. In certain embodiments, the Sirt1 polypeptide variants have a L107P substitution and the nucleic acid variants have a T373C substitution. Genetic and/or biochemical testing may be performed to identify whether a patient carries one of the disclosed polymorphic variants. Based on the polymorphic variant the patient carries, a medical practitioner may administer an appropriate therapy, such as a sirtuin activator.
摘要翻译： 本文提供了在氨基酸残基107或核苷酸373处具有取代的Sirt1多态变体。在某些实施方案中，Sirt1多肽变体具有L107P取代，并且核酸变体具有T373C取代。 可以进行遗传和/或生化测试以鉴定患者是否携带所公开的多态变体之一。 基于患者携带的多态变体，医师可以施用适当的治疗，例如沉默调节蛋白激活剂。
-
公开(公告)号：US20110015192A1
公开(公告)日：2011-01-20
申请号：US12891667
申请日：2010-09-27
申请人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
IPC分类号： A61K31/5377 , C07D413/14 , C07D403/14 , A61K31/498 , C07D417/14 , A61K31/4439 , A61P3/00
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
-
公开(公告)号：US20100215632A1
公开(公告)日：2010-08-26
申请号：US12450252
申请日：2008-03-19
申请人： Olivier Boss , Siva Worcester , Andre Iffland , Jesse Smith , Jill Milne , Michael Jirousek
发明人： Olivier Boss , Siva Worcester , Andre Iffland , Jesse Smith , Jill Milne , Michael Jirousek
CPC分类号： G01N33/6893 , C12Q1/34
摘要： Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.
摘要翻译： 提供了用于监测受试者中的沉默调节蛋白调节的方法，例如在用沉默调节蛋白调节化合物治疗期间。 所述方法涉及确定来自受试者的生物样品中一种或多种沉默调节蛋白的生物标志物的表达水平。 还提供了用于鉴定使用一种或多种沉默调节蛋白的生物标志物来调节沉默调节蛋白的活性的化合物的方法。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.036 秒)
