公开(公告)号：US08069851B2

公开(公告)日：2011-12-06

申请号：US12456807

申请日：2009-06-22

申请人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon-Harcourt ,  Sameer Shirgoankar

发明人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon-Harcourt ,  Sameer Shirgoankar

IPC分类号： A61M11/00

CPC分类号： A61M15/0028 ,  A61M15/003 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2206/16

摘要： An aerosolization apparatus comprises a housing defining a chamber having a plurality of air inlets. The chamber contains an aerosolizable pharmaceutical formulation or is sized to receive a receptacle which contains an aerosolizable pharmaceutical formulation. A shield covers at least one of the air inlets or a portion of at least one of the air inlets. The shield prevents blockage of the air inlet by a user grasping the apparatus and inadvertently covering the air inlet. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the receptacle.

摘要翻译： 雾化装置包括限定具有多个空气入口的腔室的壳体。 该室含有可雾化的药物制剂，或者其尺寸适于容纳含有可雾化药物制剂的容器。 屏蔽罩覆盖至少一个空气入口或至少一个空气入口的一部分。 屏蔽件防止使用者抓住装置堵塞空气入口并且无意中覆盖空气入口。 端部与壳体相关联。 端部的尺寸和形状被设计成容纳在使用者的嘴或鼻中，使得使用者可以通过端部吸入以吸入已经离开容器的雾化的药物制剂。

公开(公告)号：US20090260623A1

公开(公告)日：2009-10-22

申请号：US12456807

申请日：2009-06-22

申请人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon-Harcourt ,  Sameer Shirgoankar

发明人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon-Harcourt ,  Sameer Shirgoankar

IPC分类号： A61M11/00

CPC分类号： A61M15/0028 ,  A61M15/003 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2206/16

摘要： An aerosolization apparatus comprises a housing defining a chamber having a plurality of air inlets. The chamber contains an aersolizable pharmaceutical formulation or is sized to receive a receptacle which contains an aerosolizable pharmaceutical formulation. A shield covers at least one of the air inlets or a portion of at least one of the air inlets. The shield prevents blockage of the air inlet by a user grasping the apparatus and inadvertently covering the air inlet. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the receptacle.

摘要翻译： 雾化装置包括限定具有多个空气入口的腔室的壳体。 该腔室含有可溶胶体药物制剂，或者其尺寸适于容纳含有可雾化药物制剂的容器。 屏蔽罩覆盖至少一个空气入口或至少一个空气入口的一部分。 屏蔽件防止使用者抓住装置堵塞空气入口并且无意中覆盖空气入口。 端部与壳体相关联。 端部的尺寸和形状被设计成容纳在使用者的嘴或鼻中，使得使用者可以通过端部吸入以吸入已经离开容器的雾化的药物制剂。

公开(公告)号：US10207066B2

公开(公告)日：2019-02-19

申请号：US10821624

申请日：2004-04-09

申请人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon-Harcourt ,  Mark Glusker ,  Steve Paboojian

发明人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon-Harcourt ,  Mark Glusker ,  Steve Paboojian

IPC分类号： A61M15/00

摘要： An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.

公开(公告)号：US20080115785A1

公开(公告)日：2008-05-22

申请号：US11980929

申请日：2007-10-31

申请人： Stephen William Eason ,  Quentin John Harmer ,  Matthew Neil Sarkar ,  John Pinon ,  Michael John Dunkley ,  Roger William Clarke ,  Stephen Henry Hill

发明人： Stephen William Eason ,  Quentin John Harmer ,  Matthew Neil Sarkar ,  John Pinon ,  Michael John Dunkley ,  Roger William Clarke ,  Stephen Henry Hill

IPC分类号： A61M15/00

CPC分类号： A61M15/0028 ,  A61M11/002 ,  A61M11/06 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2206/16

摘要： An inhaler for producing an inhalable aerosol of a powdered medicament includes an aerosolizing device in the form of a vortex chamber 1. The vortex chamber 1 has a tangential inlet port 3 and an axial port 2. The ratio of the diameter of the vortex chamber 1 to the diameter of the exit port 2 is between 4 and 12. The length of the exit port 2 is less than its diameter. The cross-section of the inlet port 3 is rectangular and is defined at the bottom and at the radially outermost edge by the walls of the vortex chamber 1. The cross-sectional area of the inlet conduit 7, which supplies the medicament in a gas flow to the inlet port 3, decreases in the direction towards the vortex chamber 1. The inlet conduit 7 may be curved. The inhaler is capable of repeatably producing an aerosol of a medicament with a high proportion of particles in the range 1 to 3 microns, while using a 20 relatively small amount of energy.

摘要翻译： 用于产生粉末药物的可吸入气溶胶的吸入器包括涡流室1形式的雾化装置。 涡流室1具有切向入口3和轴向端口2。 涡流室1的直径与出口2的直径之比在4和12之间。 出口2的长度小于其直径。 入口3的横截面是矩形的，并且通过涡流室1的壁限定在底部和径向最外边缘处。 入口管道7的横截面积，其将气体流中的药物供应到入口3，在朝向涡流室1的方向上减小。 入口导管7可以是弯曲的。 吸入器能够重复地产生具有1至3微米范围内的高比例颗粒的药物气溶胶，同时使用20个较小量的能量。

公开(公告)号：US06579494B1

公开(公告)日：2003-06-17

申请号：US09537307

申请日：2000-03-29

申请人： Jacques Chevallet ,  Thierry Court ,  Michael John Dunkley ,  Alain Frugier ,  Lennart Jonsson ,  Nicholas John Kerry ,  Hiram Rada ,  Jean-Louis Romarie

发明人： Jacques Chevallet ,  Thierry Court ,  Michael John Dunkley ,  Alain Frugier ,  Lennart Jonsson ,  Nicholas John Kerry ,  Hiram Rada ,  Jean-Louis Romarie

IPC分类号： G05B2300

CPC分类号： A61L2/28 ,  A61L2/0023 ,  A61L2/04

摘要： A device for preparing a sterile liquid includes structure for validating a sterilization treatment applied to the liquid. The validating structure includes structure for calculating, from at least one operating parameter of the device, a parameter representing a sterilizing value for the sterilization treatment, and structure for comparing the calculated parameter to a threshold value corresponding to the sterility of the liquid.

摘要翻译： 用于制备无菌液体的装置包括用于验证施加到液体的灭菌处理的结构。 验证结构包括从装置的至少一个操作参数计算表示灭菌处理的消毒值的参数的结构，以及用于将所计算的参数与对应于液体的无菌性的阈值进行比较的结构。

公开(公告)号：US07559325B2

公开(公告)日：2009-07-14

申请号：US10822850

申请日：2004-04-09

申请人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon Harcourt ,  Sameer Shirgoankar

发明人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon Harcourt ,  Sameer Shirgoankar

IPC分类号： A61M11/00

CPC分类号： A61M15/0028 ,  A61M15/003 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2206/16

摘要： An aerosolization apparatus comprises a housing defining a chamber having a plurality of air inlets. The chamber contains an aersolizable pharmaceutical formulation or is sized to receive a receptacle which contains an aerosolizable pharmaceutical formulation. A shield covers at least one of the air inlets or a portion of at least one of the air inlets. The shield prevents blockage of the air inlet by a user grasping the apparatus and inadvertently covering the air inlet. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the receptacle.

摘要翻译： 雾化装置包括限定具有多个空气入口的腔室的壳体。 该腔室含有可溶胶体药物制剂，或者其尺寸适于容纳含有可雾化药物制剂的容器。 屏蔽罩覆盖至少一个空气入口或至少一个空气入口的一部分。 屏蔽件防止使用者抓住装置堵塞空气入口并且无意中覆盖空气入口。 端部与壳体相关联。 端部的尺寸和形状被设计成容纳在使用者的嘴或鼻中，使得使用者可以通过端部吸入以吸入已经离开容器的雾化的药物制剂。

公开(公告)号：US06967002B1

公开(公告)日：2005-11-22

申请号：US10088310

申请日：2000-04-04

申请人： Raymond Anthony Edgson ,  Michael John Dunkley ,  Richard J. Hammond ,  Eric Wilkinson

发明人： Raymond Anthony Edgson ,  Michael John Dunkley ,  Richard J. Hammond ,  Eric Wilkinson

IPC分类号： A61J3/00 ,  A61K31/19 ,  A61K31/7004 ,  A61K33/06 ,  A61K33/10 ,  A61K33/14 ,  A61K35/02 ,  A61L2/00 ,  A61L2/04 ,  A61M1/14 ,  A61M1/28 ,  B01D21/30 ,  B01D35/18 ,  B01J19/00

CPC分类号： A61L2/0023 ,  A61L2/04

摘要： A method and apparatus for producing a sterile medical solution is disclosed. The method includes providing at least two components, a first component including bicarbonate ions and a second component including glucose or calcium ions, preheating the first component to a first temperature and the second component to a second temperature, heat sterilizing the first and second components separately to a third and fourth temperatures respectively, the third and fourth temperatures being sterilizing temperatures for the first and second components, maintaining the first and second components approximately at their respective third and fourth temperatures, so as to sterilize the first and second components, cooling the first and second components and delivering the first and second components to a mixing device.

摘要翻译： 公开了一种生产无菌医用溶液的方法和装置。 该方法包括提供至少两个组分，包括碳酸氢根离子的第一组分和包含葡萄糖或钙离子的第二组分，将第一组分预热至第一温度，将第二组分预热至第二温度，分别对第一组分和第二组分进行热灭菌 分别为第三和第四温度，第三和第四温度是第一和第二组分的灭菌温度，将第一和第二组分保持在相应的第三和第四温度，以对第一和第二组分灭菌，冷却 第一和第二部件，并将第一和第二部件输送到混合装置。

公开(公告)号：US06818179B1

公开(公告)日：2004-11-16

申请号：US09937738

申请日：2002-04-15

申请人： Raymond Anthony Edgson ,  Michael John Dunkley ,  Richard J. Hammond ,  Eric Wilkinson

发明人： Raymond Anthony Edgson ,  Michael John Dunkley ,  Richard J. Hammond ,  Eric Wilkinson

IPC分类号： A61L200

CPC分类号： A61L2/0023 ,  A61L2/04

摘要： Methods and apparatus for sterilizing heat sensitive fluids are provided. The methods include providing a first heat sensitive fluid component, providing a second fluid component, heating the second fluid component to a temperature greater than a predetermined sterilizing temperature, mixing the first heat sensitive fluid component with the heated second fluid component to heat the first heat sensitive fluid components and provide a mixed fluid at a temperature at least up to the predetermined sterilizing temperature, and maintaining the mixed fluid at that temperature for a predetermined sterilizing period. Apparatus for carrying out this method is also provided.

摘要翻译： 提供了对热敏流体进行灭菌的方法和装置。 所述方法包括提供第一热敏流体组分，提供第二流体组分，将第二流体组分加热到大于预定灭菌温度的温度，将第一热敏流体组分与加热的第二流体组分混合以加热第一热 并且在至少达到预定灭菌温度的温度下提供混合流体，并将混合流体在该温度下保持预定的灭菌期。 还提供了用于执行该方法的装置。