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公开(公告)号:US08748466B2
公开(公告)日:2014-06-10
申请号:US14110157
申请日:2012-03-23
申请人: Joseph Alan Abramite , Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人: Joseph Alan Abramite , Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号: C07D261/08 , C07D413/04
CPC分类号: C07D261/14 , C07D261/08 , C07D413/04
摘要: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
摘要翻译: 本发明涉及一类新的异羟肟酸衍生物,它们用作LpxC抑制剂,更具体地,其用于治疗细菌感染。
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2.
公开(公告)号:US08853258B2
公开(公告)日:2014-10-07
申请号:US13501776
申请日:2010-10-04
IPC分类号: A61K31/382 , A61K31/47 , A61K31/661 , C07D215/06 , C07C317/44 , C07D231/56 , C07F9/12 , C07C323/65 , C07C317/46 , C07D213/56 , C07C317/48 , C07D263/08 , C07D295/03 , C07D263/20 , C07D335/02 , C07D213/30
CPC分类号: C07C317/50 , C07C317/44 , C07C317/46 , C07C317/48 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/16 , C07C2601/18 , C07D213/30 , C07D213/56 , C07D215/06 , C07D231/12 , C07D231/56 , C07D233/36 , C07D239/26 , C07D261/08 , C07D263/08 , C07D263/20 , C07D295/03 , C07D335/02 , C07F9/09 , C07F9/12
摘要: The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, R1 and R2 are as described hereinabove, and their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.
摘要翻译: 本发明涉及新一类式I的异羟肟酸衍生物,其中变量G,T,D,L,A,X,R 1和R 2如上所述,并且它们作为LpxC抑制剂的用途,更具体地 它们用于治疗细菌感染。
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3.Imidazole, Pyrazole, and Triazole Derivatives Useful As Antibacterial Agents 有权
标题翻译: 咪唑,吡唑和三唑衍生物作为抗菌剂有用公开(公告)号:US20140038975A1
公开(公告)日:2014-02-06
申请号:US14110165
申请日:2012-03-27
申请人: Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人: Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号: C07D413/10 , C07D249/06 , C07D413/04 , C07D233/61 , C07D231/12 , C07D403/04
CPC分类号: C07D413/10 , A61K31/4192 , C07D231/12 , C07D233/61 , C07D249/06 , C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , Y02A50/473
摘要: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
摘要翻译: 本发明涉及一类新的异羟肟酸衍生物,它们用作LpxC抑制剂,更具体地,其用于治疗细菌感染。
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4.
公开(公告)号:US20120258948A1
公开(公告)日:2012-10-11
申请号:US13515607
申请日:2010-12-06
申请人: Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人: Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号: A61K31/4412 , A61K31/4439 , C07D213/64 , C07D401/12 , A61K31/4545 , A61K31/4418 , C07D405/10 , A61K31/4433 , A61K31/506 , C07D413/10 , C07D213/643 , A61K31/444 , A61K31/4709 , A61K31/4427 , C07D401/14 , C07D417/12 , A61K31/541 , C07D413/12 , A61K31/5377 , A61P31/04 , C07D401/10
CPC分类号: A61K31/4412 , A61K31/4439 , C07D211/86 , C07D213/64 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , Y02A50/473
摘要: The present invention is directed to a new class of hydroxamic acid derivatives of formula I, wherein the variables G, T, D, L, R1, R2, R3 are as described herein, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections in a patient in need thereof.
摘要翻译: 本发明涉及一类新的式I的异羟肟酸衍生物,其中变量G,T,D,L,R 1,R 2,R 3如本文所述,它们作为LpxC抑制剂的用途,更具体地说, 在有需要的患者中治疗细菌感染。
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公开(公告)号:US06376506B1
公开(公告)日:2002-04-23
申请号:US09469677
申请日:1999-12-22
申请人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号: A61K31435
CPC分类号: C07D295/26 , C07C307/06 , C07D211/36 , C07D213/74 , C07D401/04 , C07D401/12
摘要: This invention relates to sulfamides of formula (I) that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译: 本发明涉及作为金属蛋白酶抑制剂的式(I)的磺酰胺,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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公开(公告)号:US5998412A
公开(公告)日:1999-12-07
申请号:US9951
申请日:1998-01-21
申请人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号: A61K20060101 , C07C20060101 , C07C307/06 , C07D20060101 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , C07D491/048 , A61K31/435 , A61K31/495 , C07D495/04
CPC分类号: C07D211/36 , C07C307/06 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12
摘要: This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
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7.
公开(公告)号:US08664401B2
公开(公告)日:2014-03-04
申请号:US13515607
申请日:2010-12-06
申请人: Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人: Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号: C07D401/00 , A61K31/444
CPC分类号: A61K31/4412 , A61K31/4439 , C07D211/86 , C07D213/64 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , Y02A50/473
摘要: The present invention is directed to a new class of hydroxamic acid derivatives of formula I, wherein the variables G, T, D, L, R1, R2, R3 are as described herein, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections in a patient in need thereof.
摘要翻译: 本发明涉及一类新的式I的异羟肟酸衍生物,其中变量G,T,D,L,R 1,R 2,R 3如本文所述,它们作为LpxC抑制剂的用途,更具体地说, 在有需要的患者中治疗细菌感染。
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8.Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates 失效
标题翻译: 用于制备鼻病毒蛋白酶抑制剂和关键中间体的高效合成路线公开(公告)号:US06774243B2
公开(公告)日:2004-08-10
申请号:US09984555
申请日:2001-10-30
申请人: Qingping Tian , Naresh K. Nayyar , Srinivasan Babu , Junhua Tao , Terence Jarold Moran , Raymond Dagnino, Jr. , Lennert J. Mitchell, Jr. , Travis Paul Remarchuk , Michael Joseph Melnick , Steven Lee Bender
发明人: Qingping Tian , Naresh K. Nayyar , Srinivasan Babu , Junhua Tao , Terence Jarold Moran , Raymond Dagnino, Jr. , Lennert J. Mitchell, Jr. , Travis Paul Remarchuk , Michael Joseph Melnick , Steven Lee Bender
IPC分类号: C07D20726
CPC分类号: B01J19/2435 , B01J19/2475 , B01J2219/00033 , B01J2219/00099 , B01J2219/00103 , B01J2219/00159 , B01J2219/00162 , B01J2219/00177 , C07B2200/07 , C07C69/732 , C07C229/34 , C07C271/22 , C07C303/28 , C07D207/26 , C07D261/18 , C07D413/12 , C07C309/65
摘要: Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula I, as well as key intermediates useful in those synthetic routes. These compounds of formula I, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
摘要翻译: 用于制备式I的鼻病毒蛋白酶抑制剂的高效合成路线,以及在那些合成路线中有用的关键中间体。 这些式I化合物以及含有这些化合物的药物组合物适用于治疗患有一种或多种微小核糖核酸病毒感染的患者或宿主。
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9.Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates 失效
标题翻译: 用于制备鼻病毒蛋白酶抑制剂和关键中间体的高效合成路线公开(公告)号:US06355807B1
公开(公告)日:2002-03-12
申请号:US09643864
申请日:2000-08-23
申请人: Qingping Tian , Naresh K. Nayyar , Srinivasan Babu , Junhua Tao , Terence Jarold Moran , Raymond Dagnino, Jr. , Lennert J. Mitchell, Jr. , Travis Paul Remarchuk , Michael Joseph Melnick , Steven Lee Bender
发明人: Qingping Tian , Naresh K. Nayyar , Srinivasan Babu , Junhua Tao , Terence Jarold Moran , Raymond Dagnino, Jr. , Lennert J. Mitchell, Jr. , Travis Paul Remarchuk , Michael Joseph Melnick , Steven Lee Bender
IPC分类号: C07D20726
CPC分类号: C07D207/26 , B01J19/2435 , B01J19/2475 , B01J2219/00033 , B01J2219/00099 , B01J2219/00103 , B01J2219/00159 , B01J2219/00162 , B01J2219/00177 , C07B2200/07 , C07C69/732 , C07C229/34 , C07C271/22 , C07C303/28 , C07D261/18 , C07D413/12 , C07C309/65
摘要: Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula I, as well as key intermediates useful in those synthetic routes. These compounds of formula I, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses
摘要翻译: 用于制备式I的鼻病毒蛋白酶抑制剂的高效合成途径,以及在那些合成路线中有用的关键中间体。 这些式I化合物以及含有这些化合物的药物组合物适用于治疗感染了一种或多种微小核糖核酸病毒的患者或宿主
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公开(公告)号:US6143744A
公开(公告)日:2000-11-07
申请号:US369501
申请日:1999-08-05
申请人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号: A61K20060101 , C07C20060101 , C07C307/06 , C07D20060101 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , C07D491/048 , A61K31/16 , C07C259/06
CPC分类号: C07D211/36 , C07C307/06 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12
摘要: This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译: 本发明涉及作为金属蛋白酶抑制剂的式(I)的磺酰胺,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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