摘要:
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12Rβ2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNy production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNy production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
摘要:
A method comprises writing data to one or more static random access memory (SRAM) cells. Writing data to the one or more SRAM cells comprises applying a first data signal to at least one bit line electrically connected to the one or more SRAM memory cells, electrically disconnecting at least one of a first power supply terminal and a second power supply terminal of each of the one or more SRAM cells from a power supply and applying a word line signal to a word line electrically connected to the one or more SRAM cells. Thereafter, the at least one of the first power supply terminal and the second power supply terminal of each of the one or more SRAM cells is electrically connected to the power source.
摘要:
The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N.sup.4-acyl-2′,3′-dideoxy-5-fluorocytidine or N.sup.4-acyl-2′,3′-didehyd-ro-2′,3′-dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof
摘要:
Lubricants and drilling fluid systems comprising lubricants which form a coherent lubricating film on metal equipment, thereby prolonging equipment life even under a wide variety of conditions, including high temperature and/or high pressure conditions.
摘要:
The present invention includes compounds and compositions of β-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or compositions.
摘要:
The present invention comprises an apparatus (1) for arranging a file (2) above a keyboard (4) which is located on a desk (3) comprising a base (5), a slide (6) and an inclined support (7) for supporting the file (2), wherein the support (7) is mounted on the slide (6) and the base (5) is adapted to be arranged on the desk (3) and/or on the keyboard (4) and to guide the inclined support (7) above the keyboard (4) during a horizontal motion of the slide with respect to the base (5) from a front position to a back position, wherein an arrestor is provided in the front position.
摘要:
Interleukin-18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要:
Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagonosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.