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公开(公告)号：US07851498B2
公开(公告)日：2010-12-14
申请号：US11525573
申请日：2006-09-22
申请人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter
发明人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/54 , C07D401/12 , C07D403/12
摘要： This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
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公开(公告)号：US20100279991A1
公开(公告)日：2010-11-04
申请号：US12836615
申请日：2010-07-15
申请人： Fina Liotta , Mingde Xia , Michael P. Wachter , Scott A. Beers
发明人： Fina Liotta , Mingde Xia , Michael P. Wachter , Scott A. Beers
IPC分类号： A61K31/56 , A61K31/416 , A61P3/10 , A61P27/06 , A61P25/24 , A61P25/30 , A61P25/08 , A61P11/00 , A61P3/04 , A61P15/00 , C07D235/02 , A61K31/5377 , C07D413/12 , A61K31/454 , C07D401/12 , C07D403/06 , A61K31/496 , A61K31/55 , A61K31/53 , A61K31/4166 , A61K31/519
CPC分类号： C07D231/54
摘要： This invention is directed to a tetrahydro-cyclopentyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
摘要翻译： 本发明涉及式（I）的四氢 - 环戊基吡唑大麻素调节剂化合物：以及用于治疗，改善或预防大麻素受体介导的综合征，病症或疾病的方法。
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公开(公告)号：US5843958A
公开(公告)日：1998-12-01
申请号：US977210
申请日：1997-11-24
IPC分类号： C07D231/12 , C07D401/12 , A61K31/47
CPC分类号： C07D231/12 , C07D401/12
摘要： Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.
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公开(公告)号：US5240953A
公开(公告)日：1993-08-31
申请号：US828394
申请日：1992-01-30
IPC分类号： A61K31/41 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P27/02 , A61P43/00 , C07D249/12 , C07D403/10
CPC分类号： C07D403/10 , C07D249/12
摘要： This invention relates to novel bis-biphenyl substituted 3-mercapto-1,2,4-tetrazoles and to pharmaceutically acceptable salts thereof.The compounds are angiotensin II receptor antagonists, and are useful in treating hypertension (lowering high blood pressure), congestive heart failure, elevated ocular pressure, cerebral stroke, angina, cardiac insufficiency, myocardial infection or diabetic nephropathy.The invention also relates to pharmaceutical composition comprising a compound of the invention, a method of treating a physiological condition in a mammal that is mediated by angiotensin II which comprises administering to the mammal an effective amount of a compound of the invention, and novel processes for preparing the compounds of the invention.
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5.发明授权Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same 失效药理活性的1,5-二芳基-3-取代的吡唑及其合成方法
公开(公告)号：US5164381A
公开(公告)日：1992-11-17
申请号：US730515
申请日：1991-07-12
IPC分类号： C07C59/84 , C07C59/88 , C07D231/12 , C07D403/12 , C07D417/12
CPC分类号： C07D231/12 , C07C59/84 , C07C59/88 , C07D403/12 , C07D417/12
摘要： 1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.
摘要翻译： 公开了1,5-二芳基-3-取代的吡唑，它们的制备方法，含有它们的组合物及其使用方法。 吡唑可用于缓解哺乳动物的炎症和心血管疾病。
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6.发明授权Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides 失效药理活性的2-和3-取代的（1'，5'-二芳基-3-吡唑基）-N-羟基丙酰胺
公开(公告)号：US5051518A
公开(公告)日：1991-09-24
申请号：US534325
申请日：1990-06-04
摘要： 2- and 3-substituted (1',5'-diaryl-3'-pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.
摘要翻译： 2-和3-取代的（1'，5'-二芳基-3'-吡唑基）-N-羟基丙酰胺，其制备方法，含有它们的组合物及其使用方法。 N-羟基丙酰胺可用于减轻哺乳动物的炎症和心血管疾病。
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公开(公告)号：US4910198A
公开(公告)日：1990-03-20
申请号：US358036
申请日：1989-05-26
IPC分类号： C07D498/08
CPC分类号： C07D498/08
摘要： The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
摘要翻译： 描述了环氧苯并氮杂化合物的合成。 新型化合物具有抗溃疡活性。
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公开(公告)号：US4102895A
公开(公告)日：1978-07-25
申请号：US742940
申请日：1976-11-18
IPC分类号： C07D313/00 , A61K31/335 , A61K36/28 , A61P15/04 , A61P25/00 , C07D313/04 , C07D407/04 , C07D493/08 , C07D493/10 , C07F7/18 , C07F9/655 , C07F9/6561 , C07D319/10
CPC分类号： A61K36/28 , C07D313/04 , C07D493/08 , C07D493/10 , C07F7/1856 , C07F9/655 , C07F9/6561
摘要： Chemical compounds having a substituted oxepane ring and methods of preparing such compounds are described. The compounds are active as utero-evacuant agents.
摘要翻译： 描述了具有取代的氧杂环庚烷环的化合物及其制备方法。 这些化合物作为子宫排泄剂是有活性的。
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公开(公告)号：US08012957B2
公开(公告)日：2011-09-06
申请号：US11691713
申请日：2007-03-27
申请人： Mingde Xia , Fina Liotta , Michael P. Wachter
发明人： Mingde Xia , Fina Liotta , Michael P. Wachter
IPC分类号： A61P3/04 , A61K31/55 , C07D487/00
CPC分类号： C07D487/04
摘要： This invention is directed to a tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
摘要翻译： 本发明涉及式（I）的四氢-1H-1,2,6-三氮杂 - 薁类大麻素调节剂化合物：以及用于治疗，改善或预防大麻素受体介导的综合征，病症或疾病的方法。
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公开(公告)号：US07825151B2
公开(公告)日：2010-11-02
申请号：US11688589
申请日：2007-03-20
申请人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
发明人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/54 , C07D403/12
摘要： This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
摘要翻译： 本发明涉及式（I）的六氢 - 环辛基吡唑大麻素调节剂化合物：以及用于治疗，改善或预防大麻素受体介导的综合征，病症或疾病的方法。
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