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公开(公告)号：US08461134B2
公开(公告)日：2013-06-11
申请号：US12944690
申请日：2010-11-11
Applicant: Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
Inventor： Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
CPC classification number: C07F5/025
Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
Abstract translation: 本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US20130059803A1
公开(公告)日：2013-03-07
申请号：US13607321
申请日：2012-09-07
Applicant: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
Inventor： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC: A61K31/69 , A61P31/10 , A61K31/7028
CPC classification number: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20120115813A1
公开(公告)日：2012-05-10
申请号：US13227444
申请日：2011-09-07
Applicant: Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
Inventor： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
CPC classification number: C07F5/025
Abstract: This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
Abstract translation: 本发明涉及苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US08115026B2
公开(公告)日：2012-02-14
申请号：US12629753
申请日：2009-12-02
Applicant: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
Inventor： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC: C07F5/04
CPC classification number: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
Abstract translation: 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US20110212918A1
公开(公告)日：2011-09-01
申请号：US12944699
申请日：2010-11-11
Applicant: Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
Inventor： Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
CPC classification number: C07F5/025
Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
Abstract translation: 本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US20090291917A1
公开(公告)日：2009-11-26
申请号：US12399015
申请日：2009-03-05
Applicant: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
Inventor： Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
IPC: A61K31/69 , C07F5/02 , A61P19/00 , A61P25/00 , A61P9/00 , A61P27/02 , A61P37/00 , A61P3/00 , A61P1/00
CPC classification number: C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
Abstract translation: 公开了治疗抗炎症状的化合物和方法。
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公开(公告)号：US20120289686A1
公开(公告)日：2012-11-15
申请号：US13356488
申请日：2012-01-23
Applicant: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
Inventor： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
CPC classification number: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
Abstract translation: 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US20110136763A1
公开(公告)日：2011-06-09
申请号：US12844748
申请日：2010-07-27
Applicant: Yi Xia , Michael Richard Kevin Alley , Yasheen Zhou , Rajeshwar Singh , Charles Ding , Kathy Cao , Jacob J. Plattner , Ligong Ou , Guofeng Jia , Neerja Saraswat , Sreekanth Ramachandran , Ding Zhou
Inventor： Yi Xia , Michael Richard Kevin Alley , Yasheen Zhou , Rajeshwar Singh , Charles Ding , Kathy Cao , Jacob J. Plattner , Ligong Ou , Guofeng Jia , Neerja Saraswat , Sreekanth Ramachandran , Ding Zhou
CPC classification number: C07F5/025 , A61K31/69 , A61K45/06 , A61K2300/00
Abstract: This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.
Abstract translation: 本发明主要涉及3,4,6-三取代苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US20110124597A1
公开(公告)日：2011-05-26
申请号：US12873036
申请日：2010-08-31
Applicant: Vincent S. HERNANDEZ , Charles DING , Jacob PLATTNER , Michael Richard Kevin ALLEY , Yong-Kang ZHANG , Yanchen ZHANG
Inventor： Vincent S. HERNANDEZ , Charles DING , Jacob PLATTNER , Michael Richard Kevin ALLEY , Yong-Kang ZHANG , Yanchen ZHANG
CPC classification number: C07F5/025
Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
Abstract translation: 本发明尤其提供了可用于治疗细菌感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
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公开(公告)号：US20090227541A1
公开(公告)日：2009-09-10
申请号：US12142692
申请日：2008-06-19
Applicant: Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
Inventor： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
CPC classification number: C07F5/025 , A61K31/69 , Y02A50/387
Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
Abstract translation: 本发明尤其提供了可用于治疗细菌感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
