Substituted cyclohexyl and piperidinyl derivates as melanocortin-4 receptor modulators
    1.
    发明申请
    Substituted cyclohexyl and piperidinyl derivates as melanocortin-4 receptor modulators 审中-公开
    取代的环己基和哌啶基衍生物作为黑皮质素-4受体调节剂

    公开(公告)号:US20070155783A1

    公开(公告)日:2007-07-05

    申请号:US10550268

    申请日:2004-03-19

    摘要: The present invention relates to novel substituted cyclohexyl and piperidinyl derivatives as melanocortin-4. receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.

    摘要翻译: 本发明涉及新型取代的环己基和哌啶衍生物作为黑皮质素-4。 受体(MC-4R)调节剂。 本发明的MC-4R激动剂可用于治疗疾病和疾病如肥胖,糖尿病和性功能障碍,而MC-4R拮抗剂可用于治疗疾病和疾病如癌症恶病质,肌肉消瘦,厌食 ,焦虑和抑郁。 可以用本发明的化合物治疗涉及MC-4R调节的所有疾病和病症。