摘要:
In a method, one or more parameter values are determined for a set of pieces of audio and/or video information. The one or more parameter values are determined based at least partially on pre-defined or determined according to pre-defined rules profile information. The set of pieces of audio and/or video information represent a seamless sequence comprising combinable pieces of audio and/or video information. Further, in the method, the parameter values are used to select one or more pieces of audio and/or video information. Playback parameter values are determined for the set of pieces of audio and/or video information based at least partially on the determined one or more parameter values. The playback parameter values are provided for performing playback of the set of pieces of audio and/or video information. In order to perform the method, an apparatus, computer program and system are also disclosed.
摘要:
Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I). ##STR1##
摘要:
A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译:选自式(I)的化合物:其中:X和Y表示选自氢,卤素,烷氧基,硝基,氰基,烷基,烯基,多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义,Z表示氧或NR C c,其中R - >如说明书中所定义,Ar表示芳基或杂芳基,R 1表示氢或烷基,R 2表示选自氢,烷基 其中R a a和R b都是 - , - - - - - - - - >如说明书中所定义,R 3和R 4代表氢或烷基,R 5表示氢,或C 1-4烷基, R 1,R 2,R 2,R 2,R 2,R 2, (W 2)-W 3 -T 1或Z-CO-CH-CHAr其中R R 1,R 2,W 3,W 2,W 3,U 3, ,V,T,Z和Ar定义如下 在其描述中,其异构体及其与药学上可接受的酸或碱的加成盐,以及含有该物质的药物可用于治疗癌症。
摘要:
A compound selected from those of formula (I): wherein: B1, B2 represent carbon or nitrogen, X, Y, X1 and Y1 represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, trihaloalkyl and NRaRb wherein Ra and Rb are as defined in the description, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NRa′Rb′, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″a and —NR″a—C(O)-Ta-NR′aR′b wherein R′a, R′b, R″a and Ta are as defined in the description, R3, R4 represent hydrogen or alkyl, A represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8)— or —CH(R8)—C(O)— wherein R5, R6, R7 and R8 are as defined in the description, its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要:
A compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译:选自式(I)的化合物:其中:X和Y表示选自氢,卤素,巯基,氰基,硝基,烷基,三卤代烷基,三卤代烷基羰基氨基,-OR a,-NR a R b,-NR a -C(O) - T1,-OC(O)-T1,-O-T2-NRaRb,-O-T2-ORa,-NRa-T2-NRaRb,-NRa-T2-ORa和-NRa-T2-CO2Ra,其中Ra,Rb,T1 ,T 2如说明书中所定义,R 1表示氢或烷基,R 2表示选自氢,-OR a,-NR a R b,-NR a -C(O)-T1,-OC(O)-T1,-O- R2-NRaRb,-O-T2-ORa,-NRa-T2-NRaRb,-NRa-T2-ORa和-NRa-T2-CO2Ra,其中Ra,Rb,T1和T2如上所定义,R3和R4代表氢或 烷基,W表示式-CH(R 5)-CH(R 6) - , - CH = C(R 7) - , - C(R 7)= CH-或-C(O)-CH(R 8) R5,R6,R7和R8如说明书中所定义,它们的异构体和N-氧化物及其与药学上可接受的酸或碱的加成盐,以及含有它们的药物,可用于治疗癌症。
摘要:
A compound selected from those of formula (I): wherein: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy, R1 represents hydrogen, or alkyl, R2 represents hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyloxy, or optionally substituted amino, R3 and R4 represent hydrogen, or alkyl, R5 and R6 represent —O—CO—U—V wherein U and V are as defined in the description, or Z as defined in the description, it being understood that at least one of the R5 and R6 groups represents —O—CO—U—V, their isomers, N-oxides, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of cancer.
摘要:
A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译:选自式(I)的化合物:其中:X和Y表示选自氢,卤素,烷氧基,硝基,氰基,烷基,烯基,多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义,Z表示氧或NR C c,其中R - >如说明书中所定义,Ar表示芳基或杂芳基,R 1表示氢或烷基,R 2表示选自氢,烷基 其中R a a和R b都是 - , - - - - - - - - >如说明书中所定义,R 3和R 4代表氢或烷基,R 5表示氢,或C 1-4烷基, R 1,R 2,R 2,R 2,R 2,R 2, (W 2)-W 3 -T 1或Z-CO-CH-CHAr其中R R 1,R 2,W 3,W 2,W 3,U 3, ,V,T,Z和Ar定义如下 在其描述中,其异构体及其与药学上可接受的酸或碱的加成盐,以及含有该物质的药物可用于治疗癌症。
摘要:
A compound selected from those of formula (I): in which: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy, R1 represents hydrogen, or alkyl, R2 represents hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyloxy, or optionally substituted ammo, R3 and R4 represent hydrogen, or alkyl, A represents —CH═CH—, or —CH(R5)—CH(R6)— wherein R5 and R6 are as defined in the description, their isomers, N-oxides, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of cancer.