-
公开(公告)号:US06806279B2
公开(公告)日:2004-10-19
申请号:US10024665
申请日:2001-12-17
申请人: Michelle R. Arkin , Robert S. McDowell , Johan D. Oslob , Brian C. Raimundo , Nathan D. Waal , Chul Hyun Yu
发明人: Michelle R. Arkin , Robert S. McDowell , Johan D. Oslob , Brian C. Raimundo , Nathan D. Waal , Chul Hyun Yu
IPC分类号: C07D40104
CPC分类号: C07K5/06026 , A61K38/00 , C07K5/06034 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06165
摘要: Compounds of formulae I and I′, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, uveitis, and psoriasis), allograft rejection, and graft-versus-host disease.
摘要翻译: 式I和I'的化合物,其制备方法,含有它们的药物组合物及其使用方法。 该化合物是IL-2 / IL-2R结合的拮抗剂; 并且可用于治疗白细胞介素-2介导的疾病,例如自身免疫性疾病(例如类风湿性关节炎,多发性硬化,葡萄膜炎和银屑病),同种异体移植排斥和移植物抗宿主病。