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公开(公告)号：US20170348364A1
公开(公告)日：2017-12-07
申请号：US15686971
申请日：2017-08-25
申请人： MICROBIOS, INC.
IPC分类号： A61K35/747 , C12N1/20 , C12N1/04 , A23K50/20 , A23K50/10 , A23K50/80 , A23K50/75 , A23K50/30 , C12R1/23 , A23K10/18
CPC分类号： A61K35/747 , A23K10/18 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/75 , A23K50/80 , A23Y2220/79 , C12N1/04 , C12N1/20 , C12R1/23
摘要： Processes to produce microorganisms that can be incorporated into a microbial-based product that results in high viable cell yields and shelf-stable products are disclosed. These microbial-based products are useful for inhibiting pathogenic growth and as a food additive. A preferred microorganism is a lactic acid producing bacteria. In one embodiment, the process comprises inoculating a lactobacillus fermentation medium with lactic acid producing bacterial cells, harvesting the lactic acid producing bacterial cells at least partially during the log phases, concentrating the lactic acid producing bacterial cells, and preserving the lactic acid producing bacterial cells at a concentration of at least 5×109 cfu/ml.
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公开(公告)号：US20170333497A1
公开(公告)日：2017-11-23
申请号：US15672205
申请日：2017-08-08
申请人： MICROBIOS, INC.
IPC分类号： A61K35/747 , A61K35/744 , A61K35/742
CPC分类号： A61K35/747 , A23Y2220/07 , A23Y2280/15 , A61K35/742 , A61K35/744 , A61K2300/00 , Y02A50/473 , Y02A50/481
摘要： A bacterial composition and method that inhibits E. coli O157:H7 growth by as much as 93% and Salmonella growth by as much as 97%, together with commensurate inhibition rates against the Big-Six Escherichia coli strains referred to as the non-O157 STECs that include E. coli O121:H19; E. coli O45:H2; E. coli O103:H11; E. coli O145, E. coli O26:H11; and E. coli O111. The composition is constituted of various combinations of the following unique pathogen-inhibiting bacteria: (1) Lactobacillus animalis; (2) Enterococcus faecium (3) Pediococcus acidilactici.
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公开(公告)号：US20210121509A1
公开(公告)日：2021-04-29
申请号：US17121358
申请日：2020-12-14
申请人： MICROBIOS, INC
IPC分类号： A61K35/747 , C12R1/23 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/75 , A23K50/80 , A23K10/18 , C12N1/04 , C12N1/20
摘要： Lactobacillus-based probiotic compositions for inclusion in microbial-based products. In one instance, the microbial-based product takes the form of an animal feed additive. When used as a feed additive for animals, especially ruminants, and in particular cattle, the following benefits from the composition are noted: (i) improved milk yield in dairy cattle, (ii) improved milk composition in dairy cattle, (iii) increased weight gain-to-feed intake ratio in beef cattle (feed efficiency), and (vi) improved average daily weight gain. Another marked benefit of the compositions when used as an animal feed additive is inhibition of pathogenic growth including E. coli, Salmonella, Clostridium, Staphylococcus and Streptococcus.
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公开(公告)号：US10314869B2
公开(公告)日：2019-06-11
申请号：US15672205
申请日：2017-08-08
申请人： MICROBIOS, INC.
IPC分类号： A61K35/742 , A61K35/744 , A61K35/747
摘要： A bacterial composition and method that inhibits E. coli O157:H7 growth by as much as 93% and Salmonella growth by as much as 97%, together with commensurate inhibition rates against the Big-Six Escherichia coli strains referred to as the non-O157 STECs that include E. coli O121:H19; E. coli O45:H2; E. coli O103:H11; E. coli O145, E. coli O26:H11; and E. coli O111. The composition is constituted of various combinations of the following unique pathogen-inhibiting bacteria: (1) Lactobacillus animalis; (2) Enterococcus faecium (3) Pediococcus acidilactici.
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公开(公告)号：US20180243354A1
公开(公告)日：2018-08-30
申请号：US15905557
申请日：2018-02-26
申请人： MICROBIOS, INC.
IPC分类号： A61K35/747 , C12N1/20 , C12N1/04 , C12R1/23 , A23K10/18 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/75 , A23K50/80
CPC分类号： A61K35/747 , A23K10/18 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/75 , A23K50/80 , A23Y2220/79 , C12N1/04 , C12N1/20 , C12R1/23
摘要： Processes to produce microorganisms that can be incorporated into a microbial-based product that results in high viable cell yields and shelf-stable products are disclosed. These microbial-based products are useful for inhibiting pathogenic growth and as a food additive. A preferred microorganism is a lactic acid producing bacteria. In one embodiment, the process comprises inoculating either a fermentation medium with enterococcus or pediococcus bacterial cells, harvesting the enterococcus or pediococcus bacterial cells at least partially during the log phases, concentrating the bacterial cells, and preserving the bacterial cells at a concentration of at least 5×109 cfu/ml.
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公开(公告)号：US09724373B2
公开(公告)日：2017-08-08
申请号：US14576034
申请日：2014-12-18
申请人： MicroBios, Inc.
IPC分类号： A01N63/00 , A61K35/747 , A61K35/744 , A23K10/18 , A23K50/60
CPC分类号： A61K35/747 , A23K10/18 , A23K50/60 , A61K35/744 , A61K2300/00
摘要： Composition including a pathogen inhibiting bacterial probiotic and a fructooligosaccharide (FOS) prebiotic particularly suited as a feed additive administered to juvenile animals such as calves that promotes animal health and growth, reduces scours and mortality, and can act as an antibiotic substitute. The additive inhibits pathogen growth resulting in lower pathogen load within the animal and pathogen sheading. The prebiotic-probiotic additive includes bacteria that inhibit E. coli O157:H7 growth by as much as 93% and Salmonella growth by as much as 97%, as well as the Big-Six Escherichia coli strains. The probiotic is constituted of various combinations of four pathogen-inhibiting bacteria: Lactobacillus animalis; Lactobacillus animalis; Enterococcus faecium; and Pediococcus acidilactici.
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公开(公告)号：US20150104419A1
公开(公告)日：2015-04-16
申请号：US14575949
申请日：2014-12-18
申请人： MicroBios, Inc.
IPC分类号： A61K35/747 , A23K1/00
CPC分类号： A61K35/747 , A23Y2220/07 , A23Y2280/15 , A61K35/742 , A61K35/744 , A61K2300/00 , Y02A50/473 , Y02A50/481
摘要： A feedlot administered animal feed additive that promotes animal health and growth, reduces mortality and can act as an antibiotic substitute. The additive inhibits pathogen growth resulting in lower pathogen load within the animal and reduced pathogen sheading to the environment. The additive includes bacteria that inhibits E. coli O157:H7 growth by as much as 93% and Salmonella growth by as much as 97%, together with commensurate inhibition rates against the Big-Six Escherichia coli strains referred to as the non-O157 STECs that include E. coli O121:H19; E. coli O45:H2; E. coli O103:H11; E. coli O145, E. coli O26:H11; and E. coli O111. The additive is constituted of various combinations of the following four pathogen-inhibiting bacteria: (1) Lactobacillus animalis strain MB101; (2) Lactobacillus animalis strain MB102; (3) Enterococcus faecium strain MB505; and (4) Pediococcus acidilactici strain MB902. The bacteria are deposited with the American Type Culture Collection (ATCC).
摘要翻译： 饲养饲养动物饲料添加剂，促进动物健康和生长，降低死亡率，并可作为抗生素替代品。 添加剂抑制病原体生长，导致动物内的病原体负载降低，并减少病原体对环境的影响。 添加剂包括抑制大肠杆菌O157：H7生长多达93％，沙门氏菌生长高达97％的细菌，以及被称为非O157 STEC的大六大肠杆菌菌株的相应抑制率 包括大肠杆菌O121：H19; 大肠杆菌O45：H2; 大肠杆菌O103：H11; 大肠杆菌O145，大肠杆菌O26：H11; 和大肠杆菌O111。 添加剂由以下四种病原体抑制细菌的各种组合构成：（1）动物动物乳杆菌菌株MB101; （2）动物动物菌株MB102; （3）屎肠球菌菌株MB505; 和（4）乳酸球菌菌株MB902。 细菌保藏于美国典型培养物保藏中心（ATCC）。
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公开(公告)号：US20200078423A1
公开(公告)日：2020-03-12
申请号：US16685727
申请日：2019-11-15
申请人： MICROBIOS, INC.
IPC分类号： A61K35/747 , C12N1/20 , C12N1/04 , A23K10/18 , A23K50/80 , A23K50/75 , A23K50/30 , A23K50/20 , A23K50/10 , C12R1/23
摘要： Lactobacillus-based probiotic compositions for inclusion in microbial-based products. In one instance, the microbial-based product takes the form of an animal feed additive. When used as a feed additive for animals, especially ruminants, and in particular cattle, the following benefits from the composition are noted: (i) improved milk yield in dairy cattle, (ii) improved milk composition in dairy cattle, (iii) increased weight gain-to-feed intake ratio in beef cattle (feed efficiency), and (vi) improved average daily weight gain. Both Lactobacillus strains MB101 having ATCC Accession Number PTA-121710 and MB102 having ATCC Accession Number PTA-121711 are particularly effective at producing these results. Another marked benefit of the compositions when used as an animal feed additive is inhibition of pathogenic growth including E. coli, Salmonella, Clostridium, Staphylococcus and Streptococcus.
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公开(公告)号：US20190290708A1
公开(公告)日：2019-09-26
申请号：US16436735
申请日：2019-06-10
申请人： MICROBIOS, INC.
IPC分类号： A61K35/747 , A61K35/744 , A61K35/742
摘要： A bacterial composition and method that inhibits E. coli O157:H7 growth by as much as 93% and Salmonella growth by as much as 97%, together with commensurate inhibition rates against the Big-Six Escherichia coli strains referred to as the non-O157 STECs that include E. coli O121:H19; E. coli O45:H2; E. coli O103:H11; E. coli O145, E. coli O26:H11; and E. coli O111. The composition is constituted of various combinations of the following unique pathogen-inhibiting bacteria: (1) Lactobacillus animalis; (2) Enterococcus faecium (3) Pediococcus acidilactici.
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公开(公告)号：US09737576B2
公开(公告)日：2017-08-22
申请号：US14575974
申请日：2014-12-18
申请人： MicroBios, Inc.
IPC分类号： A01N1/00 , A61K35/747 , A61K35/744 , A61K35/742
CPC分类号： A61K35/747 , A61K35/742 , A61K35/744 , Y02A50/473 , Y02A50/481 , A61K2300/00
摘要： A dairy administered animal feed additive that promotes animal health and growth, reduces mortality and can act as an antibiotic substitute. The additive inhibits pathogen growth resulting in lower pathogen load within the animal and reduced pathogen sheading to the environment. The additive includes bacteria that inhibit E. coli O157:H7 growth by as much as 93% and Salmonella growth by as much as 97%, together with commensurate inhibition rates against the Big-Six Escherichia coli strains. The additive includes various combinations of the following pathogen-inhibiting bacteria: Lactobacillus animalis; Enterococcus faecium; and Pediococcus acidilactici.
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