NOVEL C-ARYL ANSA SGLT2 INHIBITORS
    2.
    发明申请
    NOVEL C-ARYL ANSA SGLT2 INHIBITORS 有权
    新型C-ARYL ANSA SGLT2抑制剂

    公开(公告)号:US20140213642A1

    公开(公告)日:2014-07-31

    申请号:US14123793

    申请日:2012-06-14

    CPC classification number: C07D491/056 C07D493/08

    Abstract: Disclosed is a novel C-aryl ansa compound having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. Also provided are a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.

    Abstract translation: 公开了一种对肠和肾中存在的钠依赖性葡萄糖协同转运蛋白2(SGLT2)具有抑制活性的新型C-芳基硫化合物,以及包含其作为活性成分的药物组合物,其可用于预防或治疗 代谢紊乱,特别是糖尿病。 还提供了制备该化合物的方法,以及通过使用该化合物来预防或治疗代谢紊乱,特别是糖尿病的方法。

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