公开(公告)号：US09187464B2

公开(公告)日：2015-11-17

申请号：US14125378

申请日：2012-06-15

Applicant: Carl Brooks ,  Mui Cheung ,  Hilary Schenck Eidam ,  Krista B. Goodman ,  Marlys Hammond ,  Mark A. Hilfiker ,  Tram H. Hoang ,  Jaclyn R. Patterson ,  Patrick Stoy ,  Guosen Ye

Inventor： Carl Brooks ,  Mui Cheung ,  Hilary Schenck Eidam ,  Krista B. Goodman ,  Marlys Hammond ,  Mark A. Hilfiker ,  Tram H. Hoang ,  Jaclyn R. Patterson ,  Patrick Stoy ,  Guosen Ye

IPC: C07D263/02 ,  A61K31/423 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  C07F9/6558 ,  C07D419/14

CPC classification number: C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D495/04 ,  C07F9/65583

Abstract: The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.

Abstract translation: 本发明涉及其中R1，（R2）Y，R3，R4，X和A具有本说明书中给出的含义的式（I）的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物，并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。

公开(公告)号：US20140080809A1

公开(公告)日：2014-03-20

申请号：US14118976

申请日：2012-05-18

Applicant: Donghui Qin ,  Mui Cheung ,  Hemant Joshi ,  Raghuram Tangirala ,  Sridhar Reddy Bethi

Inventor： Donghui Qin ,  Mui Cheung ,  Hemant Joshi ,  Raghuram Tangirala ,  Sridhar Reddy Bethi

IPC: C07D498/04

CPC classification number: C07D519/00 ,  C07D498/04

Abstract: This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.

Abstract translation: 本发明涉及作为酰基辅酶A：二酰基甘油酰基转移酶1（DGAT-1）的抑制剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中用于预防或治疗与DGAT有关的疾病 -1功能障碍或DGAT-1活性的调节可能具有治疗益处，包括但不限于肥胖症，肥胖症相关疾病，高甘油三酯血症，高脂蛋白血症，乳糜微粒血症，血脂异常，非酒精性脂肪性肝炎，糖尿病，胰岛素抵抗，代谢综合征，丙型肝炎病毒 感染和痤疮或其他皮肤疾病。

公开(公告)号：US08093239B2

公开(公告)日：2012-01-10

申请号：US12128099

申请日：2008-05-28

Applicant: Kevin Kuntz ,  David Edward Uehling ,  Alex Gregory Waterson ,  Kyle Allen Emmitte ,  Kirk Stevens ,  John Brad Shotwell ,  Stephon Cornell Smith ,  Kristen E. Nailor ,  James M. Salovich ,  Brian John Wilson ,  Mui Cheung ,  Robert Anthony Mook ,  Erich W. Baum ,  Ganesh Moorthy

Inventor： Kevin Kuntz ,  David Edward Uehling ,  Alex Gregory Waterson ,  Kyle Allen Emmitte ,  Kirk Stevens ,  John Brad Shotwell ,  Stephon Cornell Smith ,  Kristen E. Nailor ,  James M. Salovich ,  Brian John Wilson ,  Mui Cheung ,  Robert Anthony Mook ,  Erich W. Baum ,  Ganesh Moorthy

IPC: A61K31/55 ,  A61K31/505 ,  A61K31/497 ,  A61K31/535 ,  C07D243/08 ,  C07D413/14 ,  C07D403/14 ,  C07D239/02

CPC classification number: C07D471/04

Abstract: The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Abstract translation: 本发明提供咪唑并吡啶化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。

公开(公告)号：US20080214567A1

公开(公告)日：2008-09-04

申请号：US12065668

申请日：2006-08-28

Applicant: Mui Cheung ,  Kyle Allen Emmitte ,  James Michael Salovich

Inventor： Mui Cheung ,  Kyle Allen Emmitte ,  James Michael Salovich

IPC: A61K31/496 ,  C07D409/14 ,  A61P35/04

CPC classification number: C07D409/04 ,  C07D409/14

Abstract: The present invention provides benzimidazole thiophene compounds, pharmaceutical compositions containing the same, and their use as pharmaceutical agents.

Abstract translation: 本发明提供苯并咪唑噻吩化合物，含有它们的药物组合物及其作为药剂的用途。

公开(公告)号：US20070292513A1

公开(公告)日：2007-12-20

申请号：US11830608

申请日：2007-07-30

Applicant: Amogh Boloor ,  Mui Cheung ,  Ronda Davis ,  Philip Harris ,  Kevin Hinkle ,  Robert Mook ,  Jeffery Stafford ,  James Veal

Inventor： Amogh Boloor ,  Mui Cheung ,  Ronda Davis ,  Philip Harris ,  Kevin Hinkle ,  Robert Mook ,  Jeffery Stafford ,  James Veal

IPC: C07D403/12 ,  A61K31/506 ,  A61K9/28 ,  A61P35/00 ,  C07D231/56

CPC classification number: C07D239/30 ,  C07D231/56 ,  C07D235/08 ,  C07D403/12 ,  C07D413/14

Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

公开(公告)号：US20070287721A1

公开(公告)日：2007-12-13

申请号：US11538462

申请日：2006-10-04

Applicant: F. Leslie Boyd ,  Stanley Chamberlain ,  Mui Cheung ,  Kristjan Gudmundsson ,  Philip Harris ,  Brian Johns ,  David Jung ,  Michael Peel ,  Jennifer Badiang ,  Connie Sexton

Inventor： F. Leslie Boyd ,  Stanley Chamberlain ,  Mui Cheung ,  Kristjan Gudmundsson ,  Philip Harris ,  Brian Johns ,  David Jung ,  Michael Peel ,  Jennifer Badiang ,  Connie Sexton

IPC: A61K31/506 ,  A61K31/437 ,  A61P31/22 ,  C07D401/14 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供式（I）化合物：含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

公开(公告)号：US20070249600A1

公开(公告)日：2007-10-25

申请号：US11763524

申请日：2007-06-15

Applicant: Mui Cheung ,  Philip Harris ,  Masaichi Hasegawa ,  Satoru Ida ,  Kazuya Kano ,  Naohiko Nishigaki ,  Hideyuki Sato ,  James Veal ,  Yoshiaki Washio ,  Rob West

Inventor： Mui Cheung ,  Philip Harris ,  Masaichi Hasegawa ,  Satoru Ida ,  Kazuya Kano ,  Naohiko Nishigaki ,  Hideyuki Sato ,  James Veal ,  Yoshiaki Washio ,  Rob West

IPC: A61K31/4184 ,  A61K31/41 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  C07D235/30 ,  C07D277/82 ,  C07D401/12 ,  C07D403/06 ,  C07D413/06 ,  C07D417/10 ,  C07D471/04 ,  C07D487/14

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D235/30 ,  C07D235/32 ,  C07D263/58 ,  C07D277/82 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04

Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract translation: 本文描述了可用作TIE-2和/或VEGFR2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

公开(公告)号：US07189712B2

公开(公告)日：2007-03-13

申请号：US10530810

申请日：2003-10-10

Applicant: Matthew Lee Brown ,  Mui Cheung ,  Scott Howard Dickerson ,  Cassandra Gauthier ,  Philip Anthony Harris ,  Robert Neil Hunter ,  Gregory Pacofsky ,  Michael Robert Peel ,  Jeffrey Alan Stafford

Inventor： Matthew Lee Brown ,  Mui Cheung ,  Scott Howard Dickerson ,  Cassandra Gauthier ,  Philip Anthony Harris ,  Robert Neil Hunter ,  Gregory Pacofsky ,  Michael Robert Peel ,  Jeffrey Alan Stafford

IPC: A61K31/541 ,  A61K31/5355 ,  A61K31/496 ,  A61K31/4525 ,  A61K31/443 ,  A61K31/421 ,  C07D417/10 ,  C07D413/10

CPC classification number: C07D263/48 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12

Abstract: Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract translation: 本文描述了可用作VEGFR2，CDK2和CDK4抑制剂的恶唑衍生物。 所述的发明还包括制备这种恶唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

公开(公告)号：US07166597B2

公开(公告)日：2007-01-23

申请号：US10362146

申请日：2001-08-22

Applicant: Michael John Alberti ,  Ian Robert Baldwin ,  Mui Cheung ,  Stuart Cockerill ,  Stephen Flack ,  Philip Anthony Harris ,  David Kendall Jung ,  Gregory Peckham ,  Michael Robert Peel ,  Jennifer Gabriel Badiang ,  Kirk Stevens ,  James Marvin Veal

Inventor： Michael John Alberti ,  Ian Robert Baldwin ,  Mui Cheung ,  Stuart Cockerill ,  Stephen Flack ,  Philip Anthony Harris ,  David Kendall Jung ,  Gregory Peckham ,  Michael Robert Peel ,  Jennifer Gabriel Badiang ,  Kirk Stevens ,  James Marvin Veal

IPC: C07D471/04 ,  A61K31/437 ,  C07F5/02

CPC classification number: C07D471/04

Abstract: Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, R2, and R4 are various substituent groups, are protein kinase inhibitors

Abstract translation: 式（I）的化合物：其盐或溶剂合物或其生理功能衍生物，其中Z为CH或N，R 1，R 2和R 4 各种取代基是蛋白激酶抑制剂

公开(公告)号：US20060235043A1

公开(公告)日：2006-10-19

申请号：US11422357

申请日：2006-06-06

Applicant: Mui Cheung ,  Kristjan Gudmundsson ,  Brian Johns

Inventor： Mui Cheung ,  Kristjan Gudmundsson ,  Brian Johns

IPC: C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供式（I）化合物：含有该化合物的药物组合物，其制备方法及其作为药剂的用途。