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1.发明授权Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use 有权干扰素-γ诱导多肽，其药物组合物，其单克隆抗体及其使用方法公开(公告)号：US07355014B2
公开(公告)日：2008-04-08
申请号：US11580922
申请日：2006-10-16
申请人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
发明人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
IPC分类号： C07K16/00 , C07K16/18 , C07K16/24 , C12P21/08 , A61K38/00 , A61K38/19 , C07K14/00 , C07K14/54
CPC分类号： A61K38/2013 , A61K38/1709 , A61K38/208 , C07K16/18 , A61K2300/00
摘要： A human IFN-γ inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel INF-γ inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with INF-γ, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.
摘要翻译： 分离，纯化和表征人IFN-γ诱导多肽及其核苷酸序列。 配制含有该新型INF-γ诱导多肽或其活性片段的药物组合物，并针对该多肽或其抗原性片段产生单克隆抗体。 该多肽可以用于治疗对用INF-γ进行治疗的疾病的方法，以及用于增强NK细胞的细胞毒性或诱导LAK细胞形成的方法，例如治疗肿瘤和恶性病变。
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2.发明授权Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use 失效干扰素-γ诱导多肽，其药物组合物，其单克隆抗体及其使用方法公开(公告)号：US07135458B1
公开(公告)日：2006-11-14
申请号：US09716356
申请日：2000-11-21
申请人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
发明人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
CPC分类号： A61K38/2013 , A61K38/1709 , A61K38/208 , C07K16/18 , A61K2300/00
摘要： A human IFN-γ inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel IFN-γ inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with IFN-γ, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.
摘要翻译： 分离，纯化和表征人IFN-γ诱导多肽及其核苷酸序列。 配制含有该新型IFN-γ诱导多肽或其活性片段的药物组合物，并针对该多肽或其抗原性片段产生单克隆抗体。 该多肽可用于治疗用IFN-γ治疗的疾病的方法，以及用于增强NK细胞的细胞毒性或诱导LAK细胞形成的方法，例如治疗肿瘤和恶性病变。
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公开(公告)号：US07758853B2
公开(公告)日：2010-07-20
申请号：US09373230
申请日：1999-08-12
申请人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshi Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
发明人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshi Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
CPC分类号： C07K16/244 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2316/96 , C07K2317/76 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6872
摘要： A protein which induces the IFN-γ production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.
摘要翻译： 通过免疫活性细胞诱导IFN-γ产生的蛋白质，并且在SDS-PAGE或凝胶过滤方法上具有19,000±5,000道尔顿的分子量，在色谱聚焦上的pI为4.8±1.0。 蛋白质从小鼠肝脏中分离出来，可以通过特异性的单克隆抗体纯化。 单克隆抗体也可用于测定蛋白质。
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4.发明申请Interferon-gamma inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use 有权干扰素-γ诱导多肽，其药物组合物，其单克隆抗体及其使用方法公开(公告)号：US20070031403A1
公开(公告)日：2007-02-08
申请号：US11580922
申请日：2006-10-16
申请人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
发明人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
IPC分类号： A61K39/395
CPC分类号： A61K38/2013 , A61K38/1709 , A61K38/208 , C07K16/18 , A61K2300/00
摘要： A human IFN-γ inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel INF-γ inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with INF-γ, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.
摘要翻译： 分离，纯化和表征人IFN-γ诱导多肽及其核苷酸序列。 配制含有该新型INF-γ诱导多肽或其活性片段的药物组合物，并针对该多肽或其抗原性片段产生单克隆抗体。 该多肽可以用于治疗对用INF-γ进行治疗的疾病的方法，以及用于增强NK细胞的细胞毒性或诱导LAK细胞形成的方法，例如治疗肿瘤和恶性病变。
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5.发明授权DNA molecule encoding interferon-gamma (IFN-&lgr;) inducing factor (IGIF, IL-18) and DNA fragment thereof 有权编码干扰素-γ（IFN-γ）诱导因子（IGIF，IL-18）的DNA分子及其DNA片段公开(公告)号：US06277598B1
公开(公告)日：2001-08-21
申请号：US09251911
申请日：1999-02-19
申请人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
发明人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
IPC分类号： C12N1524
CPC分类号： C07K16/244 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2316/96 , C07K2317/76 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6872
摘要： A protein which induces the IFN-&ggr; production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein. Fragments of the protein can be used for production of antibodies, and can be produced recombinantly using appropriate medric acids, host cells and vectors. Fragments of nuclear acids may also be used as probes.
摘要翻译： 通过免疫活性细胞诱导IFN-γ产生的蛋白质，并且在SDS-PAGE或凝胶过滤方法上具有19,000±5,000道尔顿的分子量，在色谱聚焦上的pI为4.8±1.0。 蛋白质从小鼠肝脏中分离出来，可以通过特异性的单克隆抗体纯化。 单克隆抗体也可用于测定蛋白质。 蛋白质的片段可用于生产抗体，并且可以使用适当的中酸，宿主细胞和载体重组产生。 核酸的片段也可以用作探针。
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6.发明授权Monoclonal antibody specific to polypeptide which induces interferon-gamma production 失效诱导干扰素-γ产生的多肽特异性单克隆抗体公开(公告)号：US06197297B1
公开(公告)日：2001-03-06
申请号：US08558818
申请日：1995-11-15
IPC分类号： A61K39395
CPC分类号： C07K16/244 , C07K14/52 , C07K14/54 , C07K16/24
摘要： A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18, 500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-&ggr; production by immunocompetent cells with only a small amount, and does not cause serious side effects even when administered to human in a relatively-high dose.
摘要翻译： 对SDS-PAGE上分子量为18,500,3100道尔顿的多肽具有特异性的单克隆抗体，在色谱聚焦上的pI为4.9 1.0。 单克隆抗体可从杂交瘤获得，可用于纯化和检测多肽。 该多肽强烈诱导仅用少量的免疫活性细胞产生IFN-γ，并且甚至在相对高剂量施用于人时也不会引起严重的副作用
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7.发明授权Interferon-gamma (IFN-.gamma.) inducing factor (IGIF, IL-18) purified from murine liver 失效从小鼠肝脏纯化的干扰素-γ（IFN-γ）诱导因子（IGIF，IL-18）
公开(公告)号：US5912324A
公开(公告)日：1999-06-15
申请号：US502535
申请日：1995-07-14
申请人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshi Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
发明人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshi Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
CPC分类号： C07K16/244 , C07K14/52 , C07K16/24 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6872 , A61K2039/505 , C07K2316/96
摘要： A protein which induces IFN-.gamma. production by immunocompetent cells and has a molecular weight of 19,000.+-.5,000 daltons on SDS-PAGE or gel filtration and a pI of 4.8.+-.1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.
摘要翻译： 通过免疫活性细胞诱导IFN-γ产生的蛋白质，并且在SDS-PAGE或凝胶过滤上具有19,000 +/- 5,000道尔顿的分子量，在色谱聚焦上的pI为4.8 +/- 1.0。 蛋白质从小鼠肝脏中分离出来，可以通过特异性的单克隆抗体纯化。 单克隆抗体也可用于测定蛋白质。
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8.发明授权公开(公告)号：US07405048B2
公开(公告)日：2008-07-29
申请号：US10327069
申请日：2002-12-24
IPC分类号： G01K33/53
CPC分类号： C07K16/244 , C07K14/52 , C07K14/54 , C07K16/24
摘要： A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-γ production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.
摘要翻译： 对SDS-PAGE上分子量为18,500±3,000道尔顿的多肽具有特异性的单克隆抗体，在色谱聚焦上的pI为4.9±1.0。 单克隆抗体可从杂交瘤获得，可用于纯化和检测多肽。 该多肽强烈诱导免疫活性细胞仅产生少量的IFN-γ产生，即使以较高剂量施用于人，也不会引起严重的副作用。
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公开(公告)号：US20060073519A1
公开(公告)日：2006-04-06
申请号：US11224106
申请日：2005-09-13
IPC分类号： G01N33/53 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , Y02A50/412 , Y02A50/58
摘要： Disclosed are an antibody specific to interleukin 18 (IL-18) precursor, preparation processes therefor, and uses thereof. The antibody includes immunoglobulins in both forms of polyclonal and monoclonal antibodies which exhibits an immunoreactivity against IL-18 precursor at an intensity higher than against other substances. The antibody is useful in detection and purification of IL-18 precursor and in elimination and detoxification of the precursor accumulated in vivo. The detection method using the antibody is effective in qualitative and quantitative analyses for the precursor as well as in correction of imprecise results caused by assays using anti-IL-18 antibody which exhibits a cross reactivity against the precursor.
摘要翻译： 公开了对白细胞介素18（IL-18）前体特异性的抗体，其制备方法及其应用。 抗体包括两种形式的多克隆和单克隆抗体的免疫球蛋白，其以比其它物质高的强度显示出对IL-18前体的免疫反应性。 该抗体可用于检测和纯化IL-18前体以及在体内积累的前体的消除和解毒。 使用抗体的检测方法对于前体的定性和定量分析以及校正由对前体具有交叉反应性的抗IL-18抗体的测定引起的不精确结果是有效的。
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10.发明授权Monoclonal antibody specific to polypeptide which induces interferon-G&ggr; production 有权诱导干扰素-Ggamma生产的多肽特异性单克隆抗体公开(公告)号：US06509449B1
公开(公告)日：2003-01-21
申请号：US09711899
申请日：2000-11-15
IPC分类号： C07K1624
CPC分类号： C07K16/244 , C07K14/52 , C07K14/54 , C07K16/24
摘要： A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-&ggr; production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.
摘要翻译： 对SDS-PAGE上分子量为18,500 3,000道尔顿的多肽具有特异性的单克隆抗体，在色谱聚焦上的pI为4.9 1.0。 单克隆抗体可从杂交瘤获得，可用于纯化和检测多肽。 该多肽强烈诱导免疫活性细胞仅产生少量的IFN-γ产生，即使以较高剂量施用于人，也不会引起严重的副作用
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