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公开(公告)号：US20230144545A1
公开(公告)日：2023-05-11
申请号：US17768865
申请日：2020-10-20
CPC分类号： C07K16/24 , A61P29/00 , A61P11/00 , A61P31/14 , C07K2317/76 , C07K2317/565 , C07K2317/24 , A61K2039/505
摘要： The present invention provides an inflammatory pulmonary disease agent capable of effectively preventing and/or treating an inflammatory pulmonary disease, and specifically relates to a prophylactic and/or therapeutic agent for an inflammatory pulmonary disease containing, as an active ingredient, an antibody or an antibody fragment having antigen-binding activity for an S100A8/A9 heterodimer. The inflammatory pulmonary disease can be effectively prevented and/or treated by blocking interaction between S100A8/A9 and a group of receptors therefor. Specifically, the inflammatory pulmonary disease can be effectively prevented and/or treated by: blocking interaction between S100A8/A9 and RAGE, which is a receptor therefor, to suppress: the expression of NF-κB, which is a transcription factor present downstream of RAGE and induces the expression of various inflammatory cytokines; the proliferation of activated fibroblasts; and the differentiation of activated fibroblasts into myofibroblasts. In addition, the prophylactic and/or therapeutic agent for an inflammatory pulmonary disease of the present invention may also be suitably used as a prophylactic and/or therapeutic agent for COVID-19.
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公开(公告)号：US20230093890A1
公开(公告)日：2023-03-30
申请号：US17580239
申请日：2022-01-20
发明人： Eiji HIRAKI , Kazuhiro UMETANI , Kouta SHIMOMURA
摘要： A control method, a controller, and a control system including a converter and the controller are provided to improve load responsiveness of control by the converter. The converter has a primary circuit that includes a voltage generation circuit for generating a square wave and a resonant circuit for converting a waveform of the generated square wave, and a secondary circuit that is electromagnetically coupled to the primary circuit and that generates an induced electromotive force. The controller controls the voltage generation circuit by a control target power factor. To implement power factor-based control, the controller controls the voltage generation circuit, based on a derived power factor derived from an active power and an apparent power relevant to the resonant circuit in the primary circuit or a derived power factor derived from a phase of the primary circuit.
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公开(公告)号：US11515527B2
公开(公告)日：2022-11-29
申请号：US16883155
申请日：2020-05-26
摘要： A positive electrode imparts secondary battery with low temperature output characteristics, high temperature cycle characteristics and durability against high voltage. A positive electrode of secondary battery includes positive electrode current collector and positive electrode active substance layer on positive electrode current collector. The positive electrode active substance layer contains positive electrode active substance particles and oxide particles which are dispersed in positive electrode active substance layer as separate particles from positive electrode active substance particles. The positive electrode active substance particles each include coating of titanium-containing compound at the surface. The titanium-containing compound in coating is at least one compound selected from group consisting of TiO2, TinO2n−1, wherein n is integer of 3 or more, and oxides containing Li and Ti. The oxide particles include at least one oxide selected from group consisting of TiO2, TimO2m−1, wherein m is integer of 3 or more, and oxides containing Li and Ti.
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公开(公告)号：US20220364129A1
公开(公告)日：2022-11-17
申请号：US17863876
申请日：2022-07-13
发明人： Akio Tani
摘要： The present invention relates to a method including culturing a C1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C1 compound and/or glycerol as a carbon source, to thereby produce EGT.
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公开(公告)号：US11380906B2
公开(公告)日：2022-07-05
申请号：US16582971
申请日：2019-09-25
摘要： According to an aspect of the present invention, there is provided a positive electrode material which contains a positive electrode active material, and a dielectric material having a perovskite crystal structure. In the positive electrode material, in an X-ray diffraction pattern (vertical axis: diffraction intensity, horizontal axis: diffraction angle 2θ (rad)) obtained by X-ray diffraction measurement using a CuKα ray, a highest intensity peak which is a peak derived from the dielectric material and has the highest intensity is in a range satisfying 2θ=31° to 32°, and a half width x of the highest intensity peak satisfies the following expression: 0.22≤x≤0.33.
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公开(公告)号：US11275128B2
公开(公告)日：2022-03-15
申请号：US16614884
申请日：2018-03-30
发明人： Keiji Tsukada
IPC分类号： G01R33/035 , G01R33/00 , G01R33/06 , G01R33/07 , G01R33/09
摘要： Provided is a magnetic field measuring device which has good temperature stability and which enables an improvement by making it possible for the sensitivity of a Hall element, a magnetic impedance (MI) element or a magnetic resistance (MR) element, which are conventionally used extensively, to be set freely. This magnetic field measuring device comprises: a temperature maintaining means for maintaining an extremely low temperature state in which a superconductor adopts a superconducting state; a magnetic sensor which is provided inside the temperature maintaining means to detect a magnetic field; and a magnetic field space forming means for forming a magnetic field space specific to the superconducting state, by adopting a superconducting state inside the temperature maintaining means; wherein the magnetic sensor is disposed in the magnetic field space.
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公开(公告)号：US20210198317A1
公开(公告)日：2021-07-01
申请号：US17058142
申请日：2019-05-21
发明人： Masahiro NISHIBORI , Shuji MORI , Hidenori WAKE
IPC分类号： C07K7/06
摘要： The present invention provides a production inhibitor and/or scavenging promoter for reactive oxygen, and relates to a production inhibitor and/or scavenging promoter for reactive oxygen containing as an active ingredient a peptide having histidine-rich sequence. The histidine-rich sequence is the amino acid sequence identified by any one or a plurality of the following SEQ ID NOs: 2 to 8; (SEQ ID NO: 2) DLHPH; (SEQ ID NO: 3) KHHSH; (SEQ ID NO: 4) EQHPH; (SEQ ID NO: 5) GHHPH; (SEQ ID NO: 6) AHHPH; (SEQ ID NO: 7) EHDTH; and (SEQ ID NO: 8) RQHPH.
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公开(公告)号：US10987372B2
公开(公告)日：2021-04-27
申请号：US16083762
申请日：2017-03-10
申请人： KAGOSHIMA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY , DAIKIN INDUSTRIES, LTD.
发明人： Masanori Ikeda , Midori Takeda , Masanori Baba , Nobuyuki Kato
IPC分类号： A61K31/7076 , A61P1/16 , A61P31/20 , A61P31/14 , A61P35/00
摘要： It is an object of the present invention to provide a novel therapeutic agent for hepatoma viruses. Specifically, the present invention relates to an anti-hepatoma virus agent, containing as an active ingredient a compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: (wherein R1 is fluorine or hydrogen).
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公开(公告)号：US20210070782A1
公开(公告)日：2021-03-11
申请号：US16962436
申请日：2019-01-17
IPC分类号： C07F5/04
摘要： An object is to establish a technology with which a boronate ester compound can be easily and efficiently synthesized at a low cost with a small number of steps without the need for a complex chemical method and reagents that need to be carefully handled. A further object is to establish a sodium salt of a boronate ester compound that is a novel compound and a technology for synthesizing the sodium salt of a boronate ester compound. Provided are a sodium salt of a boronate ester compound and a method for synthesizing a boronate ester compound or a sodium salt of a boronate ester compound that includes reacting, in a reaction solvent, an organic chloride with a dispersion product obtained by dispersing sodium in a dispersion solvent to obtain an organic sodium compound, and reacting the obtained organic sodium compound with a borate ester compound to obtain a boronate ester compound or a sodium salt of a boronate ester compound.
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公开(公告)号：US20210070777A1
公开(公告)日：2021-03-11
申请号：US16958186
申请日：2018-12-27
摘要： An object is to establish a technology with which an organic magnesium compound can be easily and efficiently synthesized at a low cost with few steps that do not involve a complex chemical method. A method for synthesizing an organic magnesium compound includes, in a reaction solvent, reacting an organic halide represented by General Formula I (Ra—Xa) with a dispersion product obtained by dispersing sodium in a dispersion solvent to obtain an organic sodium compound represented by General Formula II (Ra—Na), and reacting the obtained organic sodium compound with a magnesium halide represented by General Formula III (Mg—(Xb)2) to obtain an organic magnesium compound represented by General Formula IV (Ra—Mg—Xb).
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