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    Delivery of polynucleotides using recombinant AAV9
    2.
    发明授权
    Delivery of polynucleotides using recombinant AAV9 有权

    公开(公告)号：US11219696B2

    公开(公告)日：2022-01-11

    申请号：US14717672

    申请日：2015-05-20

    申请人： NATIONWIDE CHILDREN'S HOSPITAL, INC.

    发明人： Brian K. Kaspar ,  Kevin Foust

    IPC分类号： C12N15/86 ,  C07K14/47 ,  A61K48/00 ,  C12N7/00

    摘要： The present invention relates to Adeno-associated virus 9 methods and materials useful for systemically delivering polynucleotides across the blood brain barrier. Accordingly, the present invention also relates to methods and materials useful for systemically delivering polynucleotides to the central and peripheral nervous systems. The present invention also relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as spinal muscle atrophy and amyotrophic lateral sclerosis as well as Pompe disease and lysosomal storage disorders. Use of the methods and materials is also indicated, for example, for treatment of Rett syndrome.

    Medical line securement system
    9.
    发明授权
    Medical line securement system 有权
    医疗线路固定系统

    公开(公告)号：US08882718B2

    公开(公告)日：2014-11-11

    申请号：US14093996

    申请日：2013-12-02

    申请人： Nationwide Children's Hospital, Inc.

    发明人： Joyce Mullet ,  Nancy Ryan-Wenger ,  Micah Skeens

    IPC分类号： A61M5/32 ,  A61M5/00 ,  A61M5/178

    CPC分类号： A61M5/1626 ,  A61M5/1418 ,  A61M25/02 ,  A61M2025/024 ,  A61M2025/0253 ,  A61M2025/026 ,  A61M2205/0205 ,  A61M2205/59 ,  A61M2205/6081

    摘要： The present invention is a protective sleeve for containing medical lines, comprising: (a) a foldable sleeve comprising first and second side panels, and adapted to be opened and closed along its longitudinal axis so as to form a conduit for medical lines, at least one of the panels being transparent, the foldable sleeve adapted to be reversibly opened along its longitudinal axis, and having releasable closures to maintain the foldable sleeve in a folded closed position; and (b) a plurality of rigid members incorporated into the sleeve and along the longitudinal axis.

    摘要翻译： 本发明是一种用于容纳医疗线路的保护套管，包括：（a）可折叠套筒，包括第一和第二侧板，并且适于沿着其纵向轴线打开和关闭，以形成用于医疗线路的导管，至少 所述面板中的一个是透明的，所述可折叠套筒适于沿其纵向轴线可逆地打开，并且具有可释放的闭合件，以将可折叠套管保持在折叠的关闭位置; 和（b）结合到套筒中并沿着纵向轴线的多个刚性构件。

    SPRAY DEVICE
    10.
    发明申请
    SPRAY DEVICE 有权
    喷雾装置

    公开(公告)号：US20140291415A1

    公开(公告)日：2014-10-02

    申请号：US14303774

    申请日：2014-06-13

    申请人： The Ohio State University ,  Nationwide Children's Hospital, Inc.

    发明人： Carolina Gill ,  Blaine Lilly ,  Thornton K. Lothrop ,  Scott Shim ,  Lara B. McKenzie ,  Kristin J. Roberts ,  Nicolas G. Nelson

    IPC分类号： B05B11/00

    CPC分类号： B05B11/3059 ,  B05B11/0027 ,  B05B11/3011

    摘要： A fluid container spray device having a trigger lock mechanism with trigger tabs extending outwardly from the trigger and cleats extending inwardly from a moveable shroud. The cleats obstruct the tabs when the shroud is in a trigger lock position. A lever extending from beneath the shroud can be depressed, thereby moving the shroud from the trigger lock position to a trigger release position. The movement of the shroud to the trigger release position moves the connected cleats from their obstructive position to a position out of the trigger tabs' path of movement, thereby permitting use of the trigger to pump fluid from the container. The shroud is biased toward the trigger lock position. Thus, release of the container by the user restores the locked configuration, thereby preventing use by children.

    摘要翻译： 具有触发器锁定机构的流体容器喷射装置，其具有从触发器向外延伸的触发器突出部和从可移动护罩向内延伸的夹板。 当护罩处于触发器锁定位置时，防滑板阻挡突起。 从护罩下方延伸的杠杆可以被压下，从而将护罩从触发器锁定位置移动到扳机释放位置。 护罩到触发器释放位置的运动将连接的防滑板从阻塞位置移动到触发突片的移动路径之外的位置，从而允许使用触发器从容器泵送流体。 护罩偏向扳机锁定位置。 因此，使用者的容器的释放恢复锁定构造，从而防止儿童的使用。