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公开(公告)号：US11123428B2
公开(公告)日：2021-09-21
申请号：US16991284
申请日：2020-08-12
IPC分类号： A61K31/496 , A61K31/341 , A61K31/575 , A61K31/702 , A61K31/5377 , A61K38/14 , A61K41/00 , A61K31/7048 , A61N1/32 , C12N13/00
摘要： Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied.
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公开(公告)号：US20170007743A1
公开(公告)日：2017-01-12
申请号：US15276048
申请日：2016-09-26
申请人： NANOVIS, LLC
发明人： MATTHEW HEDRICK , CHANG YAO
IPC分类号： A61L27/54 , C25D11/26 , C04B35/622 , A61L27/30 , C09D5/14 , C04B35/447
CPC分类号： A61L27/54 , A61L27/04 , A61L27/306 , A61L2202/21 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/61 , A61L2400/12 , A61L2420/02 , C04B35/447 , C04B35/62222 , C04B2235/447 , C09D1/00 , C09D5/14 , C09D7/61 , C23C22/05 , C23C22/78 , C25D11/02 , C25D11/26 , C25D11/34
摘要： An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.
摘要翻译： 一种抗微生物医疗装置，其包括具有金属表面的基材，所述金属表面由可以包括不锈钢，钴和钛的金属或金属合金制成。 设置在金属表面上的是第一抗微生物氧化物层，其包括可包括银，铜和锌的抗微生物金属及其组合。 第一抗菌氧化物层中的抗微生物金属的原子是第一浓度。 第一抗微生物氧化物层位于与金属表面相反的方向上。 该装置还包括第二抗微生物氧化物层，其包括可以是银，铜和锌的抗微生物金属及其组合。 存在于第二抗微生物氧化物层中的抗微生物金属的原子具有第二浓度。 第一个浓度和第二个浓度不相等。 还公开了制备抗微生物医疗装置的方法。
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公开(公告)号：US11129924B2
公开(公告)日：2021-09-28
申请号：US16776980
申请日：2020-01-30
申请人： NANOVIS, LLC
发明人： Matthew Hedrick , Chang Yao
IPC分类号： A61L27/54 , C23C22/05 , C25D11/02 , C23C22/78 , A61L27/04 , A61L27/30 , C25D11/26 , C25D11/34 , C09D1/00 , C09D7/61 , C04B35/447 , C04B35/622 , C09D5/14
摘要： An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.
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公开(公告)号：US20170296702A9
公开(公告)日：2017-10-19
申请号：US15276048
申请日：2016-09-26
申请人： NANOVIS, LLC
发明人： MATTHEW HEDRICK , CHANG YAO
IPC分类号： A61L27/54 , A61L27/04 , C25D11/02 , C23C22/78 , C04B35/622 , C09D5/14 , C25D11/26 , A61L27/30 , C04B35/447 , C25D11/34 , C23C22/05
CPC分类号： A61L27/54 , A61L27/04 , A61L27/306 , A61L2202/21 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/61 , A61L2400/12 , A61L2420/02 , C04B35/447 , C04B35/62222 , C04B2235/447 , C09D1/00 , C09D5/14 , C09D7/61 , C23C22/05 , C23C22/78 , C25D11/02 , C25D11/26 , C25D11/34
摘要： An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.
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公开(公告)号：US10576186B2
公开(公告)日：2020-03-03
申请号：US15276048
申请日：2016-09-26
申请人： NANOVIS, LLC
发明人： Matthew Hedrick , Chang Yao
IPC分类号： A61L27/54 , C23C22/05 , C25D11/02 , C23C22/78 , A61L27/04 , A61L27/30 , C25D11/26 , C25D11/34 , C09D1/00 , C09D7/61 , C04B35/447 , C04B35/622 , C09D5/14
摘要： An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.
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公开(公告)号：US20020196826A1
公开(公告)日：2002-12-26
申请号：US10064002
申请日：2002-06-03
申请人： Nanovis LLC
发明人： Robert J. Mears , Augustin Yiptong , Adam D. Cohen
IPC分类号： H01S005/00 , H01S003/063 , H01S003/08
CPC分类号： G02B6/02085 , G02B5/18 , G02B6/02057 , G02B6/122 , G02B2006/12107 , G02F1/225 , G02F1/2252 , G02F1/3136 , G02F1/3517 , G02F1/3521 , G02F1/3558 , G02F2001/212 , G02F2201/30 , G02F2201/307 , H01S5/1206 , H01S5/125 , H01S5/18361
摘要： A laser device, in particular a semiconductor laser, emitting optical radiation with a defined mode pattern can be produced from a standard Fabry-Perot (FP) laser by post-processing at the wafer level, i.e. before the wafer is separated into individual dies by cleaving/dicing. A sub-cavity is formed within the FP laser cavity. The sub-cavity has a predetermined length and is located between the FP facets. An aperiodic grating composed of a small number of contrast elements, typically less than 10, with predetermined inter-element separations and predetermined spacings relative to the sub-cavity is formed on or in the optical waveguide. The inter-element separations and the spacings relative to the sub-cavity produce a filtering function of the aperiodic grating for optical radiation propagating in the waveguide. The laser device is suitable for telecommunications applications due to its high side-mode-suppression ratio and narrow-linewidth.
摘要翻译： 可以通过在晶片级进行后处理，即在晶片被分离成单独的裸片之前，从标准的法布里 - 珀罗（FP）激光器产生具有限定模式图案的发射光辐射的激光装置，特别是半导体激光器 切割/切割 在FP激光腔内形成子腔。 子腔具有预定长度并且位于FP面之间。 在光波导上或光波导中形成有由少量对比元件（通常小于10个）组成的非周期性光栅，具有相对于子腔的预定的元件间隔离和预定间隔。 元件间分离和相对于子腔的间隔产生用于波导中传播的光辐射的非周期光栅的滤波函数。 激光器件由于具有高侧模抑制比和窄线宽，适用于电信应用。
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公开(公告)号：US20210340520A1
公开(公告)日：2021-11-04
申请号：US17369271
申请日：2021-07-07
摘要： The present disclosure relates to methods of stimulating cell proliferation, promoting differentiation of cells, regenerating cells, promoting nodule formation, and promoting myotube formation. The methods include applying one or more pulses of electricity to cells, each pulse of electricity having a duration of between about 10 nanoseconds and about 1,000 nanoseconds, wherein said pulses of electricity are applied under conditions effective to stimulate cell proliferation, promote differentiation of cells, regenerate cells, promote nodule formation, and promote myotube formation.
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公开(公告)号：US20200237965A1
公开(公告)日：2020-07-30
申请号：US16776980
申请日：2020-01-30
申请人： NANOVIS, LLC
发明人： Matthew HEDRICK , Chang YAO
IPC分类号： A61L27/54 , C23C22/05 , A61L27/04 , C23C22/78 , C25D11/02 , C04B35/447 , A61L27/30 , C04B35/622 , C09D7/61 , C25D11/26 , C25D11/34 , C09D5/14 , C09D1/00
摘要： An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.
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