公开(公告)号：US08853188B2

公开(公告)日：2014-10-07

申请号：US13402023

申请日：2012-02-22

申请人： Narasimha Swamy

发明人： Narasimha Swamy

IPC分类号： A61K31/593 ,  A61K31/695 ,  C07C401/00 ,  A61K31/59

CPC分类号： A61K31/59

摘要： Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series of small molecules designed around the structure of B3CD is expected to have growth inhibitory and apoptogenic activities toward a wide range of malignancies. B3CD shows no apparent toxicity in vivo, indicating potential value as a chemotherapeutic agent which will be particularly useful in treating highly aggressive tumors.

摘要翻译： 与calcidiol结构相关的溴乙酰氧基胆钙二醇（B3CD）对癌细胞（包括高度侵袭性的神经母细胞瘤细胞）表现出细胞毒性和凋亡活性。 围绕B3CD结构设计的一系列小分子预计具有朝向广泛恶性肿瘤的生长抑制和凋亡活性。 B3CD在体内没有明显的毒性，表明作为化学治疗剂的潜在价值，其将特别可用于治疗高度侵袭性的肿瘤。

公开(公告)号：US20120270839A1

公开(公告)日：2012-10-25

申请号：US13402023

申请日：2012-02-22

申请人： Narasimha Swamy ,  Hema Malini K. Sundaresha

发明人： Narasimha Swamy ,  Hema Malini K. Sundaresha

IPC分类号： A61K31/593 ,  A61P35/02 ,  C07D495/04 ,  C07C401/00 ,  C07F7/18 ,  C12N5/09 ,  A61P35/00 ,  A61K31/695

CPC分类号： A61K31/59

摘要： Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series of small molecules designed around the structure of B3CD is expected to have growth inhibitory and apoptogenic activities toward a wide range of malignancies. B3CD shows no apparent toxicity in vivo, indicating potential value as a chemotherapeutic agent which will be particularly useful in treating highly aggressive tumors.

摘要翻译： 与calcidiol结构相关的溴乙酰氧基胆钙二醇（B3CD）对癌细胞（包括高度侵袭性的神经母细胞瘤细胞）表现出细胞毒性和凋亡活性。 围绕B3CD结构设计的一系列小分子预计具有朝向广泛恶性肿瘤的生长抑制和凋亡活性。 B3CD在体内没有明显的毒性，表明作为化学治疗剂的潜在价值，其将特别可用于治疗高度侵袭性的肿瘤。

公开(公告)号：US20220124543A1

公开(公告)日：2022-04-21

申请号：US17561563

申请日：2021-12-23

申请人： Oner ORHAN ,  Vasuki NARASIMHA SWAMY ,  Marcel NASSAR ,  Hosein NIKOPOUR ,  Shilpa TALWAR

发明人： Oner ORHAN ,  Vasuki NARASIMHA SWAMY ,  Marcel NASSAR ,  Hosein NIKOPOUR ,  Shilpa TALWAR

IPC分类号： H04W28/02 ,  H04W24/02 ,  H04W28/08 ,  G06N3/08

摘要： The present disclosure provides connection management techniques based on graph neural networks (GNN) and deep reinforcement learning (DRL) to optimize user association and load balancing. A graph structure of a communication network is considered for the GNN architecture and DRL is used to learn parameters of the GNN algorithm/model. Connection management is defined as a combinatorial graph optimization problem, and the DRL mechanism uses the underlying graph to learn weights of the GNN for an optimal user connections or associations. The connection management techniques can consider local network features to make better decisions to balance network traffic load while network throughput is also maximized. Implementations are provided based on edge computing frameworks include the Open RAN (O-RAN) architecture. Other embodiments may be described and/or claimed.

公开(公告)号：US07038041B2

公开(公告)日：2006-05-02

申请号：US10257081

申请日：2001-04-12

申请人： Rahul Ray ,  Scott C. Mohr ,  Narasimha Swamy

发明人： Rahul Ray ,  Scott C. Mohr ,  Narasimha Swamy

IPC分类号： C07D487/22 ,  C07D209/00 ,  A61K31/555

CPC分类号： C07J43/00 ,  A61K41/0071

摘要： An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti estrogen portion, tether or linker portion and a porphyrin portion. The method of invention exploits an active process that involves strong and specific interactions between nuclear receptor and its cognate ligand.

公开(公告)号：US08583894B2

公开(公告)日：2013-11-12

申请号：US12878513

申请日：2010-09-09

申请人： Swamy Punyamurtula ,  Bharath Narasimha Swamy

发明人： Swamy Punyamurtula ,  Bharath Narasimha Swamy

IPC分类号： G06F12/08

CPC分类号： G06F12/0862 ,  G06F2212/6026 ,  Y02D10/13

摘要： A hybrid prefetch method and apparatus is disclosed. A processor includes a hybrid prefetch unit configured to generate addresses for accessing data from a system memory. The hybrid prefetch unit includes a first prediction unit configured to generate a first memory address according to a first prefetch algorithm and a second prediction unit configured to generate a second memory address according to a second prefetch algorithm. The hybrid prefetcher further includes an arbitration unit configured to select one of the first and second memory addresses and further configured to provide the selected one of the first and second memory addresses during a prefetch operation.

摘要翻译： 公开了一种混合预取方法和装置。 处理器包括配置成生成用于从系统存储器访问数据的地址的混合预取单元。 混合预取单元包括：第一预测单元，被配置为根据第一预取算法生成第一存储器地址;第二预测单元，被配置为根据第二预取算法生成第二存储器地址。 混合预取器还包括仲裁单元，其被配置为选择第一和第二存储器地址中的一个，并且还被配置为在预取操作期间提供所选择的第一和第二存储器地址之一。

公开(公告)号：US20100144671A1

公开(公告)日：2010-06-10

申请号：US11885606

申请日：2006-03-03

申请人： Narasimha Swamy ,  Hema Malini K. Sundaresha

发明人： Narasimha Swamy ,  Hema Malini K. Sundaresha

IPC分类号： A61K31/695 ,  C12N5/09 ,  A61K31/047 ,  A61K31/215 ,  A61K31/4188 ,  C07C69/533 ,  C07C69/608 ,  C07C211/25 ,  C07C43/18 ,  C07C323/15 ,  C07F7/08 ,  A61P35/00

CPC分类号： A61K31/59

摘要： Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series of small molecules designed around the structure of B3CD is expected to have growth inhibitory and apoptogenic activities toward a wide range of malignancies. B3CD shows no apparent toxicity in vivo, indicating potential value as a chemotherapeutic agent which will be particularly useful in treating highly aggressive tumors.

摘要翻译： 与calcidiol结构相关的溴乙酰氧基胆钙二醇（B3CD）对癌细胞（包括高度侵袭性的神经母细胞瘤细胞）表现出细胞毒性和凋亡活性。 围绕B3CD结构设计的一系列小分子预计具有朝向广泛恶性肿瘤的生长抑制和凋亡活性。 B3CD在体内没有明显的毒性，表明作为化学治疗剂的潜在价值，其将特别可用于治疗高度侵袭性的肿瘤。

公开(公告)号：US5783032A

公开(公告)日：1998-07-21

申请号：US725245

申请日：1996-10-04

申请人： John S. O'Callaghan ,  Tomasz Bednarek ,  Metin M. Durum ,  Narasimha Swamy

发明人： John S. O'Callaghan ,  Tomasz Bednarek ,  Metin M. Durum ,  Narasimha Swamy

IPC分类号： B65C1/02 ,  B65C9/18 ,  B32B31/00

CPC分类号： B65C9/1826 ,  B65C1/021 ,  Y10T156/1339 ,  Y10T156/1744

摘要： A linerless label applicator for forming and applying a discrete, pressure sensitive adhesive linerless label to a document is adapted to receive and advance a plurality of documents, one at a time, along a document path through the applicator. The applicator includes a label storage and feed section, a label cutting section and a label application section. The storage and feed section stores the label material in roll form thereon and feeds the material through a feed assembly into the cutting section. The label cutting section includes a label drive assembly, a label guide assembly and a cutting assembly. The drive assembly includes a feed roller and a plasma coated idler roller which contacts the label adhesive and prevents adhesion thereto. The guide assembly includes a fan/vacuum manifold which retains the non-adhesive side of the label material in contact with the cutting assembly surfaces. The cutting assembly includes self-lubricating stationary and moveable blades adapted to coact with one another to cut the label material into predetermined, discrete labels. The moveable blade is mounted to the cutting section by a parallelogram drive linkage which facilitates reciprocating and transverse movement of the blade to effect the label cut. The application section includes a vacuum provided paddle to hold the label in place while being cut and to transfer the label to a passing document. The application section includes a compression mechanism for compressing the label to the document.

摘要翻译： 用于将离散的压敏粘合剂无衬标签形成并应用于文件的无衬标签涂布器适于沿着通过涂布器的文件路径一次一个地接收和推进多个文件。 涂抹器包括标签储存和进料部分，标签切割部分和标签施加部分。 存储和进给部分将标签材料以卷形式存储在其上，并将材料通过进料组件进料到切割部分中。 标签切割部分包括标签驱动组件，标签引导组件和切割组件。 驱动组件包括进给辊和等离子体涂覆的惰辊，其与标签粘合剂接触并防止粘附到其上。 引导组件包括风扇/真空歧管，其保持标签材料的非粘性侧与切割组件表面接触。 切割组件包括自润滑固定和可移动的叶片，其适于彼此共同作用以将标签材料切割成预定的离散标签。 可移动刀片通过平行四边形驱动联动装置安装到切割部分，该驱动联动装置有助于刀片的往复运动和横向移动以实现标签切割。 应用部分包括一个真空提供的桨叶，以便在剪切时将标签保持在适当的位置，并将标签转移到通过的文件。 应用部分包括用于将标签压缩到文档的压缩机构。

公开(公告)号：US20230093673A1

公开(公告)日：2023-03-23

申请号：US17483208

申请日：2021-09-23

申请人： Vasuki Narasimha Swamy ,  Hosein Nikopour ,  Oner Orhan ,  Shilpa Talwar

发明人： Vasuki Narasimha Swamy ,  Hosein Nikopour ,  Oner Orhan ,  Shilpa Talwar

IPC分类号： H04W24/02 ,  G06N3/08 ,  G06N3/04

摘要： A computing node to implement an RL management entity in an NG wireless network includes a NIC and processing circuitry coupled to the NIC. The processing circuitry is configured to generate a plurality of network measurements for a corresponding plurality of network functions. The functions are configured as a plurality of ML models forming a multi-level hierarchy. Control signaling from an ML model of the plurality is decoded, the ML model being at a predetermined level (e.g., a lowest level) in the hierarchy. The control signaling is responsive to a corresponding network measurement and at least second control signaling from a second ML model at a level that is higher than the predetermined level. A plurality of reward functions is generated for training the ML models, based on the control signaling from the MLO model at the predetermined level in the multi-level hierarchy.

公开(公告)号：US08667225B2

公开(公告)日：2014-03-04

申请号：US12558465

申请日：2009-09-11

申请人： Benjamin T. Sander ,  Bharath Narasimha Swamy ,  Swamy Punyamurtula

发明人： Benjamin T. Sander ,  Bharath Narasimha Swamy ,  Swamy Punyamurtula

IPC分类号： G06F12/00

CPC分类号： G06F12/0862 ,  G06F12/0815 ,  G06F2212/6026

摘要： A system and method for efficient data prefetching. A data stream stored in lower-level memory comprises a contiguous block of data used in a computer program. A prefetch unit in a processor detects a data stream by identifying a sequence of storage accesses referencing a contiguous blocks of data in a monotonically increasing or decreasing manner. After a predetermined training period for a given data stream, the prefetch unit prefetches a portion of the given data stream from memory without write permission, in response to an access that does not request write permission. Also, after the training period, the prefetch unit prefetches a portion of the given data stream from lower-level memory with write permission, in response to determining there has been a prior access to the given data stream that requests write permission subsequent to a number of cache misses reaching a predetermined threshold.

摘要翻译： 一种用于高效数据预取的系统和方法。 存储在下级存储器中的数据流包括在计算机程序中使用的连续的数据块。 处理器中的预取单元通过以单调递增或递减的方式识别参考连续数据块的存储访问序列来检测数据流。 在针对给定数据流的预定训练周期之后，响应于不请求写许可的访问，预取单元从存储器中预取给定数据流的一部分而不具有写许可。 此外，在训练期之后，预取单元响应于确定先前访问给定数据流的请求后的写入权限，从而从具有写许可的下级存储器中预取给定数据流的一部分 的高速缓存未命中达到预定阈值。

公开(公告)号：US20130331383A1

公开(公告)日：2013-12-12

申请号：US13897168

申请日：2013-05-17

申请人： Henna Swamy ,  Laurent Brard ,  Rakesh K. Singh ,  Satyan Kalkunte ,  Narasimha Swamy ,  Giselle L. Saulnier Sholler ,  Kyu Kwang Kim

发明人： Giselle L. Saulnier Sholler ,  Narasimha SWAMY ,  Satyan KALKUNTE ,  Rakesh K. SINGH ,  Laurent BRARD ,  Kyu Kwang KIM

IPC分类号： A61K31/541 ,  A61K45/06

CPC分类号： A61K31/541 ,  A61K31/34 ,  A61K31/345 ,  A61K45/06

摘要： The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

摘要翻译： 本发明涉及硝基呋喃化合物，特别是Nifurtimox的合成和用途，作为治疗癌症，特别是神经母细胞瘤的药物，并且用于抑制血管生成。 本发明还提供组合物，单位剂量形式和包含该化合物的试剂盒。