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    Novel High Throughput Assay for finding new Jak3 Interacting Compounds, Biomolecules, and Inhibitors.
    2.
    发明申请
    Novel High Throughput Assay for finding new Jak3 Interacting Compounds, Biomolecules, and Inhibitors. 审中-公开
    用于寻找新的Jak3相互作用化合物，生物分子和抑制剂的新型高通量测定法。

    公开(公告)号：US20150344934A1

    公开(公告)日：2015-12-03

    申请号：US14483622

    申请日：2014-09-11

    申请人： Narendra Kumar ,  Jayshree Mishra

    发明人： Narendra Kumar ,  Jayshree Mishra

    IPC分类号： C12Q1/48

    CPC分类号： C12Q1/485 ,  C07K2319/23 ,  G01N2333/912 ,  G01N2500/04

    摘要： Janus Kinase 3 is a non-receptor tyrosine kinase that mediates signals initiated by cytokines through interactions with the receptors of cytokines. Abnormal activation of Jak3 was associated with human hematologic and epithelial malignancies. Inhibitors of Jak3 have shown utility in many different disease such as autoimmune disorders, allograft rejection during transplantation, acute lymphoblastic leukemia, Type 1 diabetes, rheumatoid arthritis and allergy and asthma. Since these inhibitors make their way into clinical trials with profound effects, it is essential to develop a sensitive, precise, and rugged screening tool to screen synthetic compounds or other biomolecules that has the potential to modulate Jak3 functions and hence treat a wide variety of diseases. Present invention relates to novel high throughput system for finding previously unknown Jak3 interacting compounds, human biomolecule (e.g. proteins or others), and those compounds that can inhibit Jak3 activations. All these identified compounds and molecules can be used for the treatment of a wide variety of diseases (listed in table 1) where Jak3 activations or its interactions with other biomolecules are essential for disease sustenance or propagation in human body.

    摘要翻译： Janus Kinase 3是一种非受体酪氨酸激酶，其通过与细胞因子受体的相互作用介导由细胞因子引发的信号。 Jak3的异常活化与人类血液学和上皮性恶性肿瘤有关。 Jak3的抑制剂已经显示出在许多不同疾病中的用途，例如自身免疫性疾病，移植期间的同种异体移植物排斥反应，急性成淋巴细胞白血病，1型糖尿病，类风湿性关节炎和变态反应和哮喘。 由于这些抑制剂进入具有深远影响的临床试验，因此必须开发一种灵敏，精确和坚固的筛选工具来筛选合成化合物或其他可能调节Jak3功能并因此治疗各种疾病的生物分子 。 本发明涉及用于发现先前未知的Jak3相互作用化合物，人类生物分子（例如蛋白质或其他物质）的新型高通量系统以及可抑制Jak3激活的那些化合物。 所有这些鉴定的化合物和分子可用于治疗各种各样的疾病（列于表1中），其中Jak3激活或其与其他生物分子的相互作用对于在人体中的疾病维持或传播是必需的。

    RADIO FREQUENCY POWER AMPLIFIER CIRCUIT AND METHOD
    6.
    发明申请
    RADIO FREQUENCY POWER AMPLIFIER CIRCUIT AND METHOD 有权
    无线电频率放大器电路和方法

    公开(公告)号：US20080012637A1

    公开(公告)日：2008-01-17

    申请号：US11420831

    申请日：2006-05-30

    申请人： NARENDRA KUMAR ARIDAS ,  MACWIEN KRISHNAMURTHI ANNAMALAI ,  JOSHUA KHAI HO LEE ,  TEIK SIEW TAN

    发明人： NARENDRA KUMAR ARIDAS ,  MACWIEN KRISHNAMURTHI ANNAMALAI ,  JOSHUA KHAI HO LEE ,  TEIK SIEW TAN

    IPC分类号： H03G3/20

    CPC分类号： H03G3/004 ,  H03F1/0211 ,  H03F3/24 ,  H03F2200/451 ,  H03F2200/504 ,  H03G3/3036

    摘要： A method (200) and radio frequency amplifier circuit (100) for adjusting a gain setting of a power amplifier (102) and a gain setting of a power amplifier driver (106) that form part of the radio frequency amplifier circuit (100). The method (200) includes selecting (220) a power output value for the power amplifier and an associated constant envelope modulated radio frequency signal supplied by the power amplifier driver (106) to the power amplifier (102) and then sensing variations (240) in a power output value of the power amplifier (102). Next there is performed adjusting (250) both the gain setting of the power amplifier (102) and adjusting the gain setting of the power amplifier driver (106) in response to the sensing so that the constant envelope modulated signal is within a linear operating region of the power amplifier (102). The gain settings of the power amplifier (102) and power amplifier driver (106) are concurrently adjusted until the power output value for the power amplifier is achieved.

    摘要翻译： 一种用于调整功率放大器（102）的增益设置的方法（200）和射频放大器电路（100）以及形成射频放大器电路（100）的一部分的功率放大器驱动器（106）的增益设置。 方法（200）包括将功率放大器的功率输出值和由功率放大器驱动器（106）提供的相关联的恒定包络调制射频信号选择（220）到功率放大器（102），然后感测变化（240） 在功率放大器（102）的功率输出值中。 接下来，响应于感测，执行功率放大器（102）的增益设置和调整功率放大器驱动器（106）的增益设置两者的调整（250），使得恒定包络线调制信号在线性操作区域内 的功率放大器（102）。 同时调整功率放大器（102）和功率放大器驱动器（106）的增益设置，直到达到功率放大器的功率输出值。

    Power control circuit and method
    7.
    发明授权
    Power control circuit and method 有权

    公开(公告)号：US07154338B2

    公开(公告)日：2006-12-26

    申请号：US11026213

    申请日：2004-12-30

    申请人： V. C. Prakash V K Chacko ,  Narendra Kumar Aridas ,  Kiat Hoe Wong

    发明人： V. C. Prakash V K Chacko ,  Narendra Kumar Aridas ,  Kiat Hoe Wong

    IPC分类号： H03G3/10

    CPC分类号： H03G3/3047

    摘要： A method (400) for controlling power and an amplifier and associated power control circuit (100) with a power amplifier (110) coupled through a current sensing resistor (Rsen) to a supply voltage line (vcc). There is also a current to voltage converter (120) having a converter output (135) and at least one converter input, the converter input being coupled to the supply voltage line (Vcc) of the power amplifier (110). A voltage reference providing circuitry (140) is coupled to a second input (152) of an integrator (150) that also has an integrator output (153) and a first input (151) coupled to the converter output (135) and a direct current biasing circuit (195) couples the integrator output ((153) to an amplifier input (111) of amplifier (110). The method (400) and circuit (100) use a time dependent pre-defined voltage characteristic supplied to the integrator (150).