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1.发明授权Nucleic acid molecules that target the vacuolar atpase C subunit and confer resistance to coleopteran pests 有权靶向液泡蛋白酶C亚基并赋予鞘翅目害虫抗性的核酸分子公开(公告)号：US09050363B2
公开(公告)日：2015-06-09
申请号：US13341613
申请日：2011-12-30
申请人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango , Matthew J. Henry
发明人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango , Matthew J. Henry
IPC分类号： C12N15/82 , A61K45/06 , A61K31/7088 , C07K14/435
CPC分类号： C12N15/1137 , A01N57/08 , A61K31/7088 , A61K45/06 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , C12N2310/531 , Y02A40/162 , A61K2300/00
摘要： This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
摘要翻译： 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。
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2.发明申请NUCLEIC ACID MOLECULES THAT TARGET THE VACUOLAR ATPASE H SUBUNIT AND CONFER RESISTANCE TO COLEOPTERAN PESTS 审中-公开靶向VACUOLAR ATP酶H亚基的核酸分子和对共培养物质的抗性公开(公告)号：US20120198586A1
公开(公告)日：2012-08-02
申请号：US13341713
申请日：2011-12-30
申请人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio Larrinua , Monica B. Olson , Navin Elango
发明人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio Larrinua , Monica B. Olson , Navin Elango
IPC分类号： A01N43/00 , C12N15/63 , C12N1/21 , C12N1/19 , A01P17/00 , A01H5/00 , A01H5/10 , A01H1/00 , C12Q1/68 , C12N15/11 , C12N5/10
CPC分类号： C07K14/43563 , C12N15/8218 , C12N15/8286 , Y02A40/162
摘要： This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
摘要翻译： 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。
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3.发明申请NUCLEIC ACID MOLECULES THAT TARGET THE RHO1 SMALL GTP-BINDING PROTEIN AND CONFER RESISTANCE TO COLEOPTERAN PESTS 有权靶向RHO1小型GTP结合蛋白的核酸分子，并且可以抵抗COOPOPTERAN PESTS公开(公告)号：US20120174260A1
公开(公告)日：2012-07-05
申请号：US13341752
申请日：2011-12-30
申请人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango
发明人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango
CPC分类号： C07K14/43563 , A61K31/713 , C12N15/8218 , C12N15/8286 , Y02A40/162 , A61K2300/00
摘要： This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
摘要翻译： 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。
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4.发明授权Nucleic acid molecules that target the RHO1 small GTP-binding protein and confer resistance to coleopteran pests 有权靶向RHO1小GTP结合蛋白并赋予鞘翅目害虫抗性的核酸分子公开(公告)号：US09012722B2
公开(公告)日：2015-04-21
申请号：US13341752
申请日：2011-12-30
申请人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango
发明人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango
IPC分类号： C12N15/113 , A01H1/00 , C07K14/435 , A61K31/713 , C12N15/82
CPC分类号： C07K14/43563 , A61K31/713 , C12N15/8218 , C12N15/8286 , Y02A40/162 , A61K2300/00
摘要： This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
摘要翻译： 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。
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5.发明授权Nucleic acid molecules that target the vacuolar ATPase H subunit and confer resistance to coleopteran pests 有权靶向液泡ATP酶H亚基并赋予鞘翅目害虫抗性的核酸分子公开(公告)号：US08987552B2
公开(公告)日：2015-03-24
申请号：US13341713
申请日：2011-12-30
申请人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango
发明人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango
IPC分类号： C12N15/82 , C07K14/435
CPC分类号： C07K14/43563 , C12N15/8218 , C12N15/8286 , Y02A40/162
摘要： Nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests are disclosed. Methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby are also disclosed.
摘要翻译： 公开了核酸分子及其通过RNA干涉介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 还公开了用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物的方法，以及由此获得的植物细胞和植物。
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6.发明申请NUCLEIC ACID MOLECULES THAT TARGET THE VACUOLAR ATPASE C SUBUNIT AND CONFER RESISTANCE TO COLEOPTERAN PESTS 有权靶向VACUOLAR ATPase C亚基的核酸分子和对COOPOPTERAN PESTS的抗性公开(公告)号：US20120174259A1
公开(公告)日：2012-07-05
申请号：US13341613
申请日：2011-12-30
申请人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango , Matthew J. Henry
发明人： Kenneth Narva , Huarong Li , Chaoxian Geng , Ignacio M. Larrinua , Monica B. Olson , Navin Elango , Matthew J. Henry
CPC分类号： C12N15/1137 , A01N57/08 , A61K31/7088 , A61K45/06 , C07K14/43563 , C12N15/8218 , C12N15/8286 , C12N2310/14 , C12N2310/531 , Y02A40/162 , A61K2300/00
摘要： This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
摘要翻译： 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。
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公开(公告)号：US20120173153A1
公开(公告)日：2012-07-05
申请号：US13332242
申请日：2011-12-20
IPC分类号： G06F19/22
CPC分类号： G16B30/00
摘要： Systems and methods for data analysis are provided. In one embodiment, a method may be provided for analysis comprising electronically receiving sequence data related to a plurality of sequences and a reference sequence, associating the sequence data with one of at least two groups, identifying a plurality of high quality read sequences from among the plurality of sequences, extracting a plurality of unique read sequences from the plurality of high quality read sequences, and aligning the plurality of unique read sequences against the reference sequence data corresponding to a reference sample. The method may further identify mutations in a targeted location, display the targeted mutations, and prioritize the technologies that caused the mutations according to their efficiency. In one example, the systems and methods are used to characterize the activity of several ZFN candidates.
摘要翻译： 提供了数据分析的系统和方法。 在一个实施例中，可以提供一种用于分析的方法，包括电子地接收与多个序列相关的序列数据和参考序列，将序列数据与至少两个组中的一个相关联，从多个序列中识别多个高质量读取序列 多个序列，从所述多个高质量读取序列提取多个唯一读取序列，以及将所述多个唯一读取序列与对应于参考样本的参考序列数据对准。 该方法可以进一步鉴定目标位置中的突变，显示目标突变，并根据其效率对引起突变的技术进行优先化。 在一个示例中，系统和方法用于表征若干ZFN候选者的活动。
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公开(公告)号：US09102946B2
公开(公告)日：2015-08-11
申请号：US13341562
申请日：2011-12-30
申请人： Kenneth Narva , Chaoxian Geng , Monica B. Olson , Huarong Li , Ignacio M. Larrinua , Navin Elango
发明人： Kenneth Narva , Chaoxian Geng , Monica B. Olson , Huarong Li , Ignacio M. Larrinua , Navin Elango
IPC分类号： C12N15/82 , C12N15/87 , C07K14/435
CPC分类号： C12N15/8218 , C07K14/43563 , C12N15/8286 , Y02A40/162
摘要： This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
摘要翻译： 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。
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9.发明申请公开(公告)号：US20120174258A1
公开(公告)日：2012-07-05
申请号：US13341562
申请日：2011-12-30
申请人： Kenneth Narva , Chaoxian Geng , Monica B. Olson , Huarong Li , Ignacio M. Larrinua , Navin Elango
发明人： Kenneth Narva , Chaoxian Geng , Monica B. Olson , Huarong Li , Ignacio M. Larrinua , Navin Elango
CPC分类号： C12N15/8218 , C07K14/43563 , C12N15/8286 , Y02A40/162
摘要： This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
摘要翻译： 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。
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