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公开(公告)号：US20170042464A1
公开(公告)日：2017-02-16
申请号：US15339831
申请日：2016-10-31
发明人： Steven Verdooner , David Biggs , Austin Blanco
CPC分类号： A61B5/4088 , A61B3/0025 , A61B3/102 , A61B3/1025 , A61B3/12 , A61B3/1233 , A61B3/1241 , A61B3/14
摘要： A method for detecting a disease such as Alzheimer's disease by analysis of retinal vasculature is disclosed. The method for detecting a disease by analysis of retinal vasculature may include applying a combination of optical retro mode illumination techniques to acquire a plurality of amyloid beta plaques and drusen images that are too small to be seen with other imaging modalities. The disease may also be detected with a non-transitory computer storage media having instructions stored thereon which, when executed, execute the method for detecting a disease by analysis of retinal vasculature. The method may track changes in lumen thickness, plaque, size, area and density of the disease by analysis of retinal vasculature over a predetermined period of time.
摘要翻译： 公开了通过分析视网膜脉管系统来检测诸如阿尔茨海默氏病之类疾病的方法。 通过分析视网膜脉管系统来检测疾病的方法可以包括应用光学复古模式照射技术的组合以获取太小的多个淀粉样蛋白β斑块和玻璃照射图像，以便不能与其它成像模态一起观察。 也可以用存储有指令的非瞬时计算机存储介质来检测该疾病，当执行该指令时，执行通过分析视网膜脉管系统来检测疾病的方法。 该方法可以通过在预定时间段内分析视网膜脉管系统来跟踪疾病的管腔厚度，斑块，大小，面积和密度的变化。
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2.发明申请SYSTEM AND METHOD FOR REJECTING AFOCAL LIGHT COLLECTED FROM AN IN VIVO HUMAN RETINA 审中-公开系统和方法，用于抑制人体视网膜中收集的眼底光公开(公告)号：US20160206199A1
公开(公告)日：2016-07-21
申请号：US14211406
申请日：2014-03-14
发明人： Austin Blanco , Steven Verdooner , David Biggs
CPC分类号： A61B3/156 , A61B3/0008 , A61B3/0025 , A61B3/1025 , A61B3/135 , G02B21/0004 , G02B21/0012 , G02B21/0044
摘要： A system and method for rejecting afocal light collected from an in vivo human retina is disclosed. The system may include a detector, a server system being in communication with the detector and a memory system with a rejection of collected afocal light and a disk having an optointerruptor and a motor, which is speed controlled via a non-transitory storage media. The method includes utilizing a series of optical shapes or codes, similar to other structured illumination systems, illuminating the series of optical shapes or codes several times, collecting and processing the series of optical shapes or codes yielding measurements of optical noise and optical signal and subtracting the noise and signal from the final image.
摘要翻译： 公开了一种用于排除从体内人视网膜收集的无光的系统和方法。 该系统可以包括检测器，与检测器通信的服务器系统以及具有收集的无焦点光的存储系统和具有光中断器和电动机的盘，其经由非暂时性存储介质进行速度控制。 该方法包括利用与其他结构化照明系统类似的一系列光学形状或代码，照亮一系列光学形状或代码多次，收集和处理产生光学噪声和光学信号的测量的一系列光学形状或代码，并减去 来自最终图像的噪音和信号。
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公开(公告)号：US09521975B2
公开(公告)日：2016-12-20
申请号：US14210403
申请日：2014-03-13
发明人： Steven Verdooner , David Biggs , Austin Blanco
CPC分类号： A61B5/4088 , A61B3/0025 , A61B3/102 , A61B3/1025 , A61B3/12 , A61B3/1233 , A61B3/1241 , A61B3/14
摘要： A method for detecting a disease such as Alzheimer's disease by analysis of retinal vasculature is disclosed. The method for detecting a disease by analysis of retinal vasculature may include applying a combination of optical retro mode illumination techniques to acquire a plurality of amyloid beta plaques and drusen images that are too small to be seen with other imaging modalities. The disease may also be detected with a non-transitory computer storage media having instructions stored thereon which, when executed, execute the method for detecting a disease by analysis of retinal vasculature. The method may track changes in lumen thickness, plaque, size, area and density of the disease by analysis of retinal vasculature over a predetermined period of time.
摘要翻译： 公开了通过分析视网膜脉管系统来检测诸如阿尔茨海默氏病之类疾病的方法。 通过分析视网膜脉管系统来检测疾病的方法可以包括应用光学复古模式照射技术的组合以获取太小的多个淀粉样蛋白β斑块和玻璃照射图像，以便不能与其它成像模态一起观察。 也可以用存储有指令的非瞬时计算机存储介质来检测该疾病，当执行该指令时，执行通过分析视网膜脉管系统来检测疾病的方法。 该方法可以通过在预定时间段内分析视网膜脉管系统来跟踪疾病的管腔厚度，斑块，大小，面积和密度的变化。
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公开(公告)号：US09521950B2
公开(公告)日：2016-12-20
申请号：US14251631
申请日：2014-04-13
CPC分类号： A61B3/0058 , A61B3/0083 , A61B3/0091 , A61B3/024 , A61B3/102 , A61B3/1208 , A61B3/132 , A61B3/135 , A61B3/14 , A61B3/145 , A61B3/152 , A61B3/158
摘要： A slit lamp mounted eye imaging, a slit lamp integrated, a handheld, OCT integrated, or attached to a separate chinrest-joystick assembly apparatus and method for producing a wide field and/or magnified views of the posterior or the anterior segments of an eye through an undilated or dilated pupil is disclosed. The apparatus images sections and focal planes and utilizes an illumination system that uses one or more LEDs, shifting optical elements, flipping masks, and/or aperture stops where the light can be delivered into the optical system on optical axis or off axis from center of optical system and return imaging path from the eye, creating artifacts in different locations on the eye image. Image processing is employed to detect and eliminate artifacts and masks from images. The apparatus can be used in combination with an OCT, microscope and can be disposed in a hand-held housing for hand-held use.
摘要翻译： 集成有狭缝灯的眼睛灯，一体化的狭缝灯，手持式的，集成的OCT，或连接到单独的chinrest-joystick组装装置和方法，用于产生眼睛的后部或前部的宽视场和/或放大视图 通过未扩张或扩张的瞳孔被公开。 设备图像部分和焦平面并且利用使用一个或多个LED，移动光学元件，翻转掩模和/或孔径光阑的照明系统，其中光可以在光轴上离开光学系统或从轴的中心离开 光学系统和从眼睛返回成像路径，在眼睛图像上的不同位置创建伪影。 采用图像处理来检测和消除图像中的伪像和掩模。 该装置可以与OCT，显微镜组合使用，并且可以放置在用于手持使用的手持外壳中。
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公开(公告)号：US20170319063A1
公开(公告)日：2017-11-09
申请号：US15590235
申请日：2017-05-09
发明人： Steven Verdooner , Rodney Sparks
CPC分类号： A61B5/7264 , A61B5/002 , A61B5/02438 , A61B5/048 , A61B5/4088 , A61B5/4809
摘要： An apparatus and method for sensing, recording and analyzing data representative events of memory lapses and function uses a wearable device (e.g., wrist, armband, pendant) having sensors to detect user gestures and vital signs for transmission and analysis by a computation unit to predict the onset of cognitive impairment related diseases.
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公开(公告)号：US09808155B2
公开(公告)日：2017-11-07
申请号：US14191401
申请日：2014-02-26
CPC分类号： A61B3/13 , A61B3/10 , A61B3/102 , A61B5/0042 , A61B5/0066 , A61B5/4064
摘要： An eye imaging apparatus to produce an image of an eye of a patient user is disclosed. The eye imaging apparatus may include a video camera, a slit lamp chinrest, a camera housing, a plurality of illumination source optics and a processing system. The eye imaging apparatus may also include a video camera, a plurality of video camera optics, a camera housing, a microscope assembly, a plurality of illumination source optics and a floor base. The eye imaging apparatus may be utilized in combination with one or more contrasting agents. The eye imaging apparatus may detect amyloid-beta plaque, amyloid or amyloid-beta peptide by a spectral signature.
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公开(公告)号：US09730580B2
公开(公告)日：2017-08-15
申请号：US14191398
申请日：2014-02-26
CPC分类号： A61B3/102 , A61B3/12 , A61B3/1208 , A61B3/14
摘要： The present invention is an apparatus and method to produce an image of an eye of a patient that includes an optical head that includes imaging optics, illumination source optics and a camera housing with a perimeter that houses the video camera optics and the illumination source optics, a slit lamp chinrest and joystick assembly that includes an adjustable head support, a movable base, a joystick that adjusts a position of the camera housing relative to the head support and the housing support that mounts the video camera, a rubber eyecup that provides an interface between the camera housing and the patient's eye that protrudes outward from the perimeter and a computer system that analyzes images and data for the presence of amyloid in a retina, and other deposits and provides a diagnosis of macular degeneration, Alzheimer's disease, traumatic brain injury, multiple concussive injury, neurodegenerative and other ocular disorders.
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公开(公告)号：US09566000B2
公开(公告)日：2017-02-14
申请号：US14208881
申请日：2014-03-13
发明人： Steven Verdooner , David Biggs , Austin Blanco
CPC分类号： A61B3/102 , G06T7/0012
摘要： A method for detecting amyloid beta plaques and drusen is disclosed. The method for detecting amyloid beta plaques and drusen may include applying a combination of optical retro mode illumination techniques to acquire a plurality of amyloid beta plaques and drusen images that are too small to be seen with other imaging modalities. The amyloid beta plaques and drusen images may also be detected with a non-transitory computer storage media having instructions stored thereon which, when executed, execute the method for detecting amyloid beta plaques and drusen. The method may track changes in plaque, size, area and density of the amyloid beta plaques and drusen over a predetermined period of time.
摘要翻译： 公开了一种检测淀粉样蛋白β斑块和玻璃疣的方法。 用于检测淀粉样蛋白β斑块和玻璃疣的方法可以包括应用光学复古模式照射技术的组合以获取太小的多个淀粉样蛋白β斑块和玻璃疣图像，以便不能与其它成像模态一起观察。 也可以用存储有指令的非暂时计算机存储介质来检测淀粉样蛋白β斑块和玻璃照片图像，所述指令在被执行时执行用于检测淀粉样β噬菌斑和玻璃疣的方法。 该方法可以在预定时间段内跟踪淀粉样蛋白β斑块和玻璃疣的斑块，大小，面积和密度的变化。
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公开(公告)号：US09480394B2
公开(公告)日：2016-11-01
申请号：US14251635
申请日：2014-04-13
CPC分类号： A61B3/0058 , A61B3/0083 , A61B3/0091 , A61B3/024 , A61B3/102 , A61B3/1208 , A61B3/132 , A61B3/135 , A61B3/14 , A61B3/145 , A61B3/152 , A61B3/158
摘要： A slit lamp mounted eye imaging a slit lamp integrated, a handheld, OCT integrated, or attached to a separate chinrest-joystick assembly apparatus for producing a wide field and/or magnified views of the posterior or the anterior segments of an eye through an undilated or dilated pupil. The apparatus images sections and focal planes and utilizes an illumination system that uses one or more LEDs, shifting optical elements, flipping masks, and/or aperture stops where the light can be delivered into the optical system on optical axis or off axis from center of optical system and return imaging path from the eye, creating artifacts in different locations on the eye image. Image processing is employed to detect and eliminate artifacts and masks from images. The apparatus can be used in combination with an OCT, microscope and can be disposed in a hand-held housing for hand-held use.
摘要翻译： 整合的裂隙灯，集成的手术式OCT，或连接到单独的chinrest-joystick组装装置上的裂隙灯安装的眼睛，用于通过未被剥离的眼睛产生眼睛的后部或前部的宽视场和/或放大视图 或扩大瞳孔。 设备图像部分和焦平面并且利用使用一个或多个LED，移动光学元件，翻转掩模和/或孔径光阑的照明系统，其中光可以在光轴上离开光学系统或从轴的中心离开 光学系统和从眼睛返回成像路径，在眼睛图像上的不同位置创建伪影。 采用图像处理来检测和消除图像中的伪像和掩模。 该装置可以与OCT，显微镜组合使用，并且可以放置在用于手持使用的手持外壳中。
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公开(公告)号：US10058246B2
公开(公告)日：2018-08-28
申请号：US14211406
申请日：2014-03-14
发明人： Austin Blanco , Steven Verdooner , David Biggs
CPC分类号： A61B3/156 , A61B3/0008 , A61B3/0025 , A61B3/1025 , A61B3/135 , G02B21/0004 , G02B21/0012 , G02B21/0044
摘要： A system and method for rejecting afocal light collected from an in vivo human retina is disclosed. The system may include a detector, a server system being in communication with the detector and a memory system with a rejection of collected afocal light and a disk having an optointerruptor and a motor, which is speed controlled via a non-transitory storage media. The method includes utilizing a series of optical shapes or codes, similar to other structured illumination systems, illuminating the series of optical shapes or codes several times, collecting and processing the series of optical shapes or codes yielding measurements of optical noise and optical signal and subtracting the noise and signal from the final image.
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