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6 条记录 (耗时 0.015 秒)

    Transcription factor DP-1
    3.
    发明授权
    Transcription factor DP-1 失效
    转录因子DP-1

    公开(公告)号：US07160677B1

    公开(公告)日：2007-01-09

    申请号：US09645572

    申请日：2000-08-25

    申请人： Nicholas Barrie La Thangue

    发明人： Nicholas Barrie La Thangue

    IPC分类号： C16Q1/70

    CPC分类号： C12Q1/6897 ,  C07K14/4705

    摘要： The invention provides a polynucleotide in substantially isolated form which includes a contiguous sequence of nucleotides which is capable of selectively hybridizing to SEQ ID NO: 1 or the complement of SEQ ID NO: 1, and a polypeptide in substantially isolated form which includes: (a) the protein in SEQ ID NO: 2; or (b) an allelic variant or species homologue thereof; or (c) a protein at least 70% homologous to (a); or (d) a fragment of any one of (a) to (c) capable of forming a complex with the E2 F-1 protein or related family member; or (e) a fragment of any one of (a) to (c) of at least 15 amino acids.

    摘要翻译： 本发明提供了基本上分离形式的多核苷酸，其包括能够与SEQ ID NO：1或SEQ ID NO：1的互补序列选择性杂交的连续核苷酸序列和基本上分离形式的多肽，其包括：（a ）SEQ ID NO：2中的蛋白质; 或（b）等位基因变体或其物种同系物; 或（c）与（a）至少70％同源的蛋白质; 或（d）能够与E2F-1蛋白质或相关家族成员形成复合物的（a）至（c）中任一项的片段; 或（e）至少15个氨基酸的（a）至（c）中任一项的片段。

    JMY, a co-activator for p300/CBP, nucleic acid encoding JMY and uses thereof
    4.
    发明授权
    JMY, a co-activator for p300/CBP, nucleic acid encoding JMY and uses thereof 失效
    JMY，p300 / CBP的共活化剂，编码JMY的核酸及其用途

    公开(公告)号：US06692929B2

    公开(公告)日：2004-02-17

    申请号：US09912917

    申请日：2001-07-25

    申请人： Nicholas Barrie La Thangue ,  Noriko Shikama

    发明人： Nicholas Barrie La Thangue ,  Noriko Shikama

    IPC分类号： G01N3353

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  C07K14/4738

    摘要： The invention provides an isolated nucleic acid (SEQ ID NO:1) encoding a novel protein, JMY, which is found to be a co-activator of p300/CBP. The invention also provides JMY polypeptides and antibodies thereto, as well as assays for modulators of the cell cycle which target the interaction of JMY with transcription factors such as E2F; ER or TBP.

    摘要翻译： 本发明提供了编码新型蛋白质JMY的分离的核酸（SEQ ID NO：1），其被发现是p300 / CBP的共激活剂。 本发明还提供JMY多肽及其抗体，以及针对JMY与转录因子如E2F的相互作用的细胞周期调节剂的测定; ER或TBP。

    Acetylation of pRb by p300 assay method for compounds which modulate this process
    5.
    发明授权
    Acetylation of pRb by p300 assay method for compounds which modulate this process 失效
    通过p300测定方法对调节此过程的化合物进行pRb的乙酰化

    公开(公告)号：US07238493B2

    公开(公告)日：2007-07-03

    申请号：US10344243

    申请日：2001-08-09

    申请人： Nicholas Barrie la Thangue ,  Ho Man Chan

    发明人： Nicholas Barrie la Thangue ,  Ho Man Chan

    IPC分类号： C12Q1/00 ,  C12C1/02 ,  C12C1/04 ,  G01N33/573

    CPC分类号： G01N33/5011

    摘要： The present invention is based upon the finding that the protein p300 has acetylation activity which is directed to the retinoblastoma tumour suppressor protein pRb by the presence in the cell of the adenovirus E1A protein. This represents a target for modulators of the cell cycle, to which end the invention provides an assay for a modulator of acetylation of pRb by p300, which comprises: a) bringing into contact a p300 protein a pRb protein and a putative modulator compound under conditions where the p300 protein, in the absence of said modulator is capable of acetylating the pRb protein; b) providing conditions for acetylation of said pRb protein; and c) measuring the degree of inhibition of acetylation caused by said modulator compound.

    摘要翻译： 本发明基于蛋白质p300具有通过在腺病毒E1A蛋白质的细胞中的存在而导向视网膜母细胞瘤肿瘤抑制蛋白质pRb的乙酰化活性的发现。 这表示细胞周期的调节剂的靶标，本发明的最后本发明提供了p300对pRb的乙酰化调节剂的测定法，其包括：a）在条件下使p300蛋白与推定的调节剂化合物接触 其中p300蛋白在没有所述调节剂的情况下能够乙酰化pRb蛋白; b）提供所述pRb蛋白的乙酰化条件; 和c）测量由所述调节剂化合物引起的乙酰化抑制程度。

    JMY, a co-activator for p300/CBP, nucleic acid encoding JMY and uses thereof
    6.
    发明授权
    JMY, a co-activator for p300/CBP, nucleic acid encoding JMY and uses thereof 有权
    JMY，p300 / CBP的共活化剂，编码JMY的核酸及其用途

    公开(公告)号：US06376215B1

    公开(公告)日：2002-04-23

    申请号：US09311236

    申请日：1999-05-13

    申请人： Nicholas Barrie La Thangue ,  Noriko Shikama

    发明人： Nicholas Barrie La Thangue ,  Noriko Shikama

    IPC分类号： C12N1512

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  C07K14/4738

    摘要： The invention provides an isolated nucleic acid (SEQ ID NO:1) encoding a novel protein, JMY, which is found to be a co-activator of p300/CBP. The invention also provides JMY polypeptides and antibodies thereto, as well as assays for modulators of the cell cycle which target the interaction of JMY with transcription factors such as E2F, ER or TBP.

    摘要翻译： 本发明提供了编码新型蛋白质JMY的分离的核酸（SEQ ID NO：1），其被发现是p300 / CBP的共激活剂。 本发明还提供JMY多肽及其抗体，以及针对JMY与转录因子例如E2F，ER或TBP的相互作用的细胞周期调节剂的测定。