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公开(公告)号：US08846681B2
公开(公告)日：2014-09-30
申请号：US13160351
申请日：2011-06-14
申请人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
发明人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
IPC分类号： A61K31/497 , A61P25/16 , A61P35/00 , A61P29/00 , A61P9/00 , A61P25/28 , C07D405/12 , C07D403/12 , C07D409/12 , C07D401/12 , C07D403/04 , C07D239/70 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D407/14
CPC分类号： C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US08680114B2
公开(公告)日：2014-03-25
申请号：US12567258
申请日：2009-09-25
申请人： Ian S. Mitchell , Keith L. Spencer , Peter Stengel , Yongxin Han , Nicholas C. Kallan , Mark Munson , Guy P. A. Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Rui Xu , Chang Rao , Bing Wang , April L. Bernacki
发明人： Ian S. Mitchell , Keith L. Spencer , Peter Stengel , Yongxin Han , Nicholas C. Kallan , Mark Munson , Guy P. A. Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Rui Xu , Chang Rao , Bing Wang , April L. Bernacki
IPC分类号： A61K31/47 , A01N43/42 , C07D215/00
CPC分类号： C07D239/94 , B41M3/008 , B44F1/10 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , G09F13/16 , Y10T428/24802 , Y10T428/24851 , Y10T428/25 , Y10T428/31507 , Y10T428/31551 , Y10T428/31786 , Y10T428/31855
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供包括分解对映异构体，非对映异构体，溶剂化物和药学上可接受的盐的化合物，其包含式为：A-L-CR，其中CR为环状核心基团，L为连接基团，A如本文所定义。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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3.发明申请公开(公告)号：US20120329808A1
公开(公告)日：2012-12-27
申请号：US12307526
申请日：2007-07-05
申请人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik
发明人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik
IPC分类号： A61K31/519 , A61P29/00 , A61P15/02 , A61P9/00 , A61P25/28 , A61P17/00 , C07D495/04 , A61P35/00
CPC分类号： C07D495/04
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供了包括分解对映异构体，非对映异构体，溶剂合物和其药学上可接受的盐的化合物，其包含式：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US09303040B2
公开(公告)日：2016-04-05
申请号：US12307526
申请日：2007-07-05
申请人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik
发明人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik
IPC分类号： A61K31/496 , C07D409/02 , C07D495/04
CPC分类号： C07D495/04
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供了包括分解对映异构体，非对映异构体，溶剂合物和其药学上可接受的盐的化合物，其包含式：还提供使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US08377937B2
公开(公告)日：2013-02-19
申请号：US12667850
申请日：2008-07-03
申请人： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Jun Liang , Brian S. Safina
发明人： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Jun Liang , Brian S. Safina
IPC分类号： C07D239/70 , A61K31/517
CPC分类号： C07D239/70 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20120157448A1
公开(公告)日：2012-06-21
申请号：US13302876
申请日：2011-11-22
申请人： Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Nicholas C. Kallan , Andrew T. Metcalf , Brad Newhouse , Tony P. Tang , Allen A. Thomas , Michael Siu , Malcolm Huestis , Matthew Volgraf
发明人： Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Nicholas C. Kallan , Andrew T. Metcalf , Brad Newhouse , Tony P. Tang , Allen A. Thomas , Michael Siu , Malcolm Huestis , Matthew Volgraf
IPC分类号： A61K31/4439 , C07D491/20 , A61K31/527 , C07D513/10 , A61K31/444 , A61K31/424 , C07D498/10 , C07D513/20 , A61P25/28 , C07D491/107 , C07D498/20 , A61K31/547
CPC分类号： C07D498/20 , C07D491/107 , C07D491/20 , C07D498/10 , C07D513/10 , C07D513/20
摘要： The invention provides novel tricyclic compounds of Formula I′ that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
摘要翻译： 本发明提供抑制APP分解酶切割的新颖的式I'三环化合物，并且可用作治疗神经变性疾病的治疗剂。
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7.发明申请公开(公告)号：US20110269773A1
公开(公告)日：2011-11-03
申请号：US12307537
申请日：2007-07-05
申请人： Ian S. Mitchell , James F. Blake , Rul Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Jose R. Bencsik
发明人： Ian S. Mitchell , James F. Blake , Rul Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Jose R. Bencsik
IPC分类号： A61K31/519 , A61P29/00 , A61P17/00 , A61P9/00 , A61P25/28 , A61P15/00 , C07D491/048 , A61P35/00
CPC分类号： C07D493/04
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供包含式（I）的分解的对映体，非对映异构体，溶剂化物和药学上可接受的盐的化合物：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗过度增殖性疾病 作为癌症。
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公开(公告)号：US20110245230A1
公开(公告)日：2011-10-06
申请号：US13160351
申请日：2011-06-14
申请人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
发明人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
IPC分类号： A61K31/397 , A61K31/497 , A61K31/5377 , A61P29/00 , A61P35/00 , A61P19/02 , A61P25/00 , A61P1/00 , A61P3/04 , A61P25/28 , A61P11/00 , A61P31/00 , A61P25/16 , A61P37/06
CPC分类号： C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：US08003651B2
公开(公告)日：2011-08-23
申请号：US11773946
申请日：2007-07-05
申请人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
发明人： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
IPC分类号： C07D239/70 , A61K31/497 , A61P35/00 , A61P29/00 , A61P25/28 , A61P9/00
CPC分类号： C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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10.发明授权公开(公告)号：US08853216B2
公开(公告)日：2014-10-07
申请号：US12811983
申请日：2009-01-09
申请人： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang , James Graham
发明人： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang , James Graham
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00 , A61P29/00 , A61P25/00 , A61P9/00 , A61P15/02 , A61P17/00
CPC分类号： C07D239/70
摘要： The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供了包含式I的化合物及其药学上可接受的盐。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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