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公开(公告)号:US20090281139A1
公开(公告)日:2009-11-12
申请号:US12507907
申请日:2009-07-23
IPC分类号: A61K31/4725 , C07D245/00 , A61P7/02
CPC分类号: C07D401/12 , C07D217/22 , C07D245/04 , C07D255/04 , C07D273/02 , C07D403/12 , C07D413/12 , C07D417/12
摘要: The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, L, M, W, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of the serine protease coagulation factor VIIa which can be used as medicaments.
摘要翻译: 本发明一般涉及式(I)的新型大环或其立体异构体,互变异构体,药学上可接受的盐,溶剂合物或前药,其中变量A,B,L,M,W,Z,R 1,R 2,R 3, R4,R5,R6,R7,R8,R9和R10如本文所定义。 这些化合物是可用作药物的丝氨酸蛋白酶凝血因子VIIa的选择性抑制剂。