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公开(公告)号：US20090227504A1
公开(公告)日：2009-09-10
申请号：US12371156
申请日：2009-02-13
Applicant: Niels Kristian Klausen , Soren Bjorn , Carsten Behrens , Patrick William Garibay
Inventor： Niels Kristian Klausen , Soren Bjorn , Carsten Behrens , Patrick William Garibay
CPC classification number: A61K38/4846 , A61K47/60 , C07K14/755
Abstract: The invention concerns a preparation comprising a plurality of Factor VII polypeptides or Factor VII-related polypeptides, wherein the polypeptides comprise asparagine-linked and/or serine-linked oligosaccharide chains, and wherein at least one oligosaccharide group is covalently attached to at least one polymeric group.
Abstract translation: 本发明涉及包含多个因子VII多肽或因子VII相关多肽的制剂，其中所述多肽包含天冬酰胺连接和/或丝氨酸连接的寡糖链，并且其中至少一个寡糖基团共价连接至至少一个聚合物 组。
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公开(公告)号：US06903069B2
公开(公告)日：2005-06-07
申请号：US09969357
申请日：2001-10-02
Applicant: Hans Kurt Pingel , Niels Kristian Klausen
Inventor： Hans Kurt Pingel , Niels Kristian Klausen
IPC: C12N15/09 , A61K38/00 , A61K38/48 , A61P7/04 , C07K14/47 , C07K14/745 , C12N1/15 , C12N1/19 , C12N5/10 , C12N9/64 , C12N15/12 , C12P21/02 , C12Q1/02 , A61K35/14 , C07K14/00 , C12N15/00
CPC classification number: C12N9/6437 , A61K38/00 , A61K38/4846 , C12P21/02 , C12Y304/21021 , G01N2400/02 , Y10S514/802 , Y10S514/834
Abstract: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.
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公开(公告)号：US08053410B2
公开(公告)日：2011-11-08
申请号：US12371156
申请日：2009-02-13
Applicant: Niels Kristian Klausen , Soren Bjorn , Carsten Behrens , Patrick William Garibay
Inventor： Niels Kristian Klausen , Soren Bjorn , Carsten Behrens , Patrick William Garibay
CPC classification number: A61K38/4846 , A61K47/60 , C07K14/755
Abstract: The invention concerns a preparation comprising a plurality of Factor VII polypeptides or Factor VII-related polypeptides, wherein the polypeptides comprise asparagine-linked and/or serine-linked oligosaccharide chains, and wherein at least one oligosaccharide group is covalently attached to at least one polymeric group.
Abstract translation: 本发明涉及包含多个因子VII多肽或因子VII相关多肽的制剂，其中所述多肽包含天冬酰胺连接和/或丝氨酸连接的寡糖链，并且其中至少一个寡糖基团共价连接至至少一个聚合物 组。
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公开(公告)号：US20090281022A1
公开(公告)日：2009-11-12
申请号：US12503498
申请日：2009-07-15
Applicant: HANS KURT PINGEL , Niels Kristian Klausen
Inventor： HANS KURT PINGEL , Niels Kristian Klausen
IPC: A61K38/36 , C12P21/02 , C07K14/745
CPC classification number: C12N9/6437 , A61K38/00 , A61K38/4846 , C12P21/02 , C12Y304/21021 , G01N2400/02 , Y10S514/802 , Y10S514/834
Abstract: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.
Abstract translation: 本发明提供了表现出预定的糖型图案的因子VIIa多肽或因子VIIa相关多肽的制剂。 本发明的制剂表现出改善的功能性质，并且可用于治疗因子VII介导的病症。
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5.发明申请Use of Galactose Oxidase for Selective Chemical Conjugation of Protractor Molecules to Proteins of Therapeutic Interest 审中-公开半乳糖氧化酶用于选择性化学结合量角器分子对治疗兴趣蛋白质的应用
公开(公告)号：US20100028939A1
公开(公告)日：2010-02-04
申请号：US12060383
申请日：2008-04-01
Applicant: Carsten Behrens , Patrick William Garibay , Magali Zundel , Niels Kristian Klausen , Soren E. Bjorn
Inventor： Carsten Behrens , Patrick William Garibay , Magali Zundel , Niels Kristian Klausen , Soren E. Bjorn
IPC: C12P21/00 , C07K14/435 , C07K14/745
CPC classification number: C12P21/005 , A61K47/549 , A61K47/60 , C12N9/6437
Abstract: This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.
Abstract translation: 本发明涉及新化合物，量角器分子的选择性化学共轭的方法及其用于诊断和/或治疗目的的用途。
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公开(公告)号：US20090075895A1
公开(公告)日：2009-03-19
申请号：US12325348
申请日：2008-12-01
Applicant: Hanne Nedergaard , Lars Linggaard Hansen , Niels Kristian Klausen , Troels Kornfelt , James M. Flink
Inventor： Hanne Nedergaard , Lars Linggaard Hansen , Niels Kristian Klausen , Troels Kornfelt , James M. Flink
CPC classification number: A61K47/183 , A61K9/0019 , A61K47/26
Abstract: The invention concerns a composition comprising; i) Modified Factor VII; ii) an agent suitable for keeping the pH of said composition in the range of 4 to 7 when said composition is dissolved in water; and iii) a moisture content of at the most 3%.
Abstract translation: 本发明涉及一种组合物，其包含： i）修饰因子VII; ii）当所述组合物溶解在水中时，适于将所述组合物的pH保持在4至7范围内的试剂; 和iii）水分含量最多3％。
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公开(公告)号：US20080305518A1
公开(公告)日：2008-12-11
申请号：US11579401
申请日：2005-05-03
Applicant: Niels Kristian Klausen , Daniel Rasmussen
Inventor： Niels Kristian Klausen , Daniel Rasmussen
CPC classification number: C07K14/745
Abstract: The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these.
Abstract translation: 本发明涉及包含具有改变的O-连接糖基化模式的糖蛋白的组合物，特别是因子VII，因子IX，以及制备它们的方法。
