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    Methods of treating systemic lupus erythematosus with an antibody against costimulatory signal transduction molecule ailim
    1.
    发明授权
    Methods of treating systemic lupus erythematosus with an antibody against costimulatory signal transduction molecule ailim 失效
    用针对共刺激信号转导分子的抗体治疗系统性红斑狼疮的方法

    公开(公告)号：US07988965B2

    公开(公告)日：2011-08-02

    申请号：US11752659

    申请日：2007-05-23

    申请人： Takashi Tsuji ,  Katsunari Tezuka ,  Nobuaki Hori

    发明人： Takashi Tsuji ,  Katsunari Tezuka ,  Nobuaki Hori

    IPC分类号： A61K39/395

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2818 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

    摘要： Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.

    摘要翻译： 用AILIM分子作为抗原，使用基因工程技术产生的产生抗体的转基因小鼠的免疫导致能够结合AILIM并能够控制多种生物反应的各种人单克隆抗体（例如，细胞增殖 ，细胞因子产生，免疫细胞溶解，细胞死亡，诱导ADCC等）与AILIM介导的共刺激信号（二级信号）转导相关。 此外，已经揭示了人单克隆抗体有效治疗和预防与AILIM介导的共刺激信号转导相关的各种疾病，能够抑制疾病的发病和/或进展。

    Human monoclonal antibody against a costimulatory signal transduction molecule AILIM
    2.
    发明授权
    Human monoclonal antibody against a costimulatory signal transduction molecule AILIM 有权
    针对共刺激信号转导分子AILIM的人单克隆抗体

    公开(公告)号：US06803039B2

    公开(公告)日：2004-10-12

    申请号：US09859053

    申请日：2001-05-16

    申请人： Takashi Tsuji ,  Katsunari Tezuka ,  Nobuaki Hori

    发明人： Takashi Tsuji ,  Katsunari Tezuka ,  Nobuaki Hori

    IPC分类号： A61K39395

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2818 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

    摘要： Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.

    摘要翻译： 用AILIM分子作为抗原，使用基因工程技术产生的产生抗体的转基因小鼠的免疫导致能够结合AILIM并能够控制多种生物反应的各种人单克隆抗体（例如，细胞增殖 ，细胞因子产生，免疫细胞溶解，细胞死亡，诱导ADCC等）与AILIM介导的共刺激信号（二级信号）转导相关。 此外，已经揭示了人单克隆抗体有效治疗和预防与AILIM介导的共刺激信号转导相关的各种疾病，能够抑制疾病的发病和/或进展。

    Liquid foam-discharging, squeezable vessel
    5.
    发明授权
    Liquid foam-discharging, squeezable vessel 失效
    液体泡沫排放，可挤压容器

    公开(公告)号：US5467898A

    公开(公告)日：1995-11-21

    申请号：US329790

    申请日：1994-10-27

    申请人： Nobuaki Hori

    发明人： Nobuaki Hori

    IPC分类号： B05B7/00 ,  B05B11/00 ,  B05B11/04

    CPC分类号： B05B7/0037 ,  B05B11/0029 ,  B05B11/043 ,  B05B7/0018

    摘要： A liquid foam-discharging, squeezable bottle is disclosed, which has a twist cap screwed onto the vessel body, the twist cap being composed of an inner cap and outer cap. The inner cap has formed therein two independent fluid-passing mechanisms at about its central position and at a position adjacent thereto, respectively. One of the fluid-passing mechanism is a liquid foam-generating mechanism comprising a pipe-shaped member having a net screen on one end thereof, and the other functions as a check valve. The outer cap has engaged inside of the foam-discharging opening an adapter fully covered with a net screen on one end located nearer to the contents of the vessel. This vessel enables one to rapidly discharge a uniform, creamy liquid foam by simple squeezing operation and, if desired, the foam can be sprayed by using an adapter having a small-diameter nozzle.

    摘要翻译： 公开了一种液体泡沫排出挤压瓶，其具有拧在容器主体上的扭转帽，扭转帽由内盖和外盖组成。 内盖在其中心位置和与其相邻的位置处分别形成有两个独立的流体通过机构。 流体通过机构之一是液体发泡机构，其包括在其一端具有网状筛网的管状部件，另一方面作为止回阀。 外盖已经在泡沫排放开口的内部接合，该适配器在位于更靠近容器的内容物的一端处被完全覆盖有网筛的适配器。 该容器使得能够通过简单的挤压操作快速排出均匀的奶油状液体泡沫，并且如果需要，可以通过使用具有小直径喷嘴的适配器喷射泡沫。