公开(公告)号：US08107158B2

公开(公告)日：2012-01-31

申请号：US12853751

申请日：2010-08-10

申请人： Kenji Yamazaki ,  Nobuyuki Doguchi ,  Shunji Takei ,  Sakae Takehana

发明人： Kenji Yamazaki ,  Nobuyuki Doguchi ,  Shunji Takei ,  Sakae Takehana

IPC分类号： G02B26/00

CPC分类号： A61B5/0071 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0075 ,  A61B5/0084

摘要： A fluorescent imaging device includes an irradiation section that irradiates an object to be examined with excitation light and reference light, an image pickup section that picks up a fluorescence image based on the excitation light and a reflected light image based on the reference light, a comparison section that compares relative intensity between the fluorescent image generated from the fluorescence image and the reflected light image generated from the reflected light image, and a selection section that selectively outputs one of the reflected light image and the fluorescent image based on the comparison result.

摘要翻译： 荧光成像装置包括：用激发光和参照光照射待检查对象的照射部，基于激发光拍摄荧光图像的摄像部和基于参照光的反射光图像;比较 比较从荧光图像生成的荧光图像与从反射光图像生成的反射光图像之间的相对强度的比较部分，以及基于比较结果选择性地输出反射光图像和荧光图像之一的选择部分。

公开(公告)号：US20110267493A1

公开(公告)日：2011-11-03

申请号：US12966368

申请日：2010-12-13

申请人： Kei KUBO ,  Nobuyuki DOGUCHI ,  Katsuichi IMAIZUMI ,  Shunji TAKEI

发明人： Kei KUBO ,  Nobuyuki DOGUCHI ,  Katsuichi IMAIZUMI ,  Shunji TAKEI

IPC分类号： H04N9/73

CPC分类号： A61B1/0638 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0646 ,  A61B1/0669 ,  G01J3/02 ,  G01J3/0235 ,  G01J3/027 ,  G01J3/10 ,  G01J3/12 ,  G01J3/4406 ,  G01J2003/1221 ,  G01N21/6456 ,  G01N2021/6421

摘要： A fluorescence observation apparatus of the present invention includes a light source section that can emit a plurality of excitation light beams for exciting a plurality of fluorescent substances and a reference light, an image pickup section that picks up images of a plurality of fluorescent light beams emitted by emitting the plurality of excitation light beams to the plurality of fluorescent substances and reflected light of the reference light, an image generation section that generates image signals corresponding to the plurality of fluorescent light beams and the reflected light of the reference light whose images have been picked up by the image pickup section, and an image processing section that assigns a plurality of fluorescent light images related to image signals corresponding to the plurality of fluorescent light beams and a reference light image related to an image signal corresponding to the reflected light of the reference light to a plurality of color channels respectively and outputs the resulting image as a synthesized image, wherein the image generation section generates an image signal in which the one fluorescent light image and the synthesized image are arranged side by side on a same screen, and the image processing section calculates, when a color tone operation is performed on any one of the plurality of image signals generated by the image generation section, a color tone adjustment coefficient for achieving color tone balance with image signals other than the image signal subjected to the color tone operation and performs color tone calculation processing on the image signals to be assigned to the plurality of color channels using the calculated color tone adjustment coefficient.

摘要翻译： 本发明的荧光观察装置包括能够发射多个用于激发多个荧光物质的激发光束和参考光的光源部，拍摄发出的多个荧光的图像的图像拾取部 通过将多个激发光束发射到多个荧光物质和参考光的反射光，产生与多个荧光相对应的图像信号的图像生成部和图像已经被照射的参考光的反射光 由图像拾取部拾取，以及图像处理部，其分配与多个荧光对应的图像信号相关的多个荧光图像，以及与对应于多个荧光的图像信号相关的参考光图像 将光参考多个颜色通道 输出所生成的图像作为合成图像，其中图像生成部分生成其中一个荧光图像和合成图像并排排列在同一屏幕上的图像信号，并且当图像处理部分 对由图像生成部生成的多个图像信号中的任一个执行色调操作，用于实现与进行色调操作的图像信号以外的图像信号的色调平衡的色调调整系数，并且执行色调计算 使用所计算的色调调整系数对要分配给多个颜色通道的图像信号进行处理。

公开(公告)号：US07226412B2

公开(公告)日：2007-06-05

申请号：US10853846

申请日：2004-05-25

申请人： Hitoshi Ueno ,  Takeshi Ozawa ,  Kazunari Nakamura ,  Isami Hirao ,  Hiroshi Ibe ,  Koichi Yoshimitsu ,  Yuichi Morizane ,  Mamoru Kaneko ,  Shunya Akimoto ,  Masaki Terakubo ,  Katsuichi Imaizumi ,  Nobuyuki Doguchi ,  Sakae Takehana ,  Kazuhiro Gono

发明人： Hitoshi Ueno ,  Takeshi Ozawa ,  Kazunari Nakamura ,  Isami Hirao ,  Hiroshi Ibe ,  Koichi Yoshimitsu ,  Yuichi Morizane ,  Mamoru Kaneko ,  Shunya Akimoto ,  Masaki Terakubo ,  Katsuichi Imaizumi ,  Nobuyuki Doguchi ,  Sakae Takehana ,  Kazuhiro Gono

IPC分类号： A61B1/05 ,  A61B1/06

CPC分类号： A61B1/00059 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B5/0071 ,  A61B5/0084

摘要： An endoscope system in accordance with an embodiment of the present invention includes an endoscope with a monochrome image pickup device for capturing reflected light and fluorescence from the body cavity, an excitation light cut filter which is installed in front of the image pickup device for shielding excitation light, and an endoscope ID which includes information on the type of the endoscope. A light source unit includes a first switching filter that irradiates light including excitation light for a fluorescent image mode and a filter for generating continuous light for a normal-light image mode. The filters switch based between the fluorescent image mode and the normal-light image mode. A second switching filter with a limiting filter that limits certain wavelengths of excitation light of the first switching filter is provided. The limiting filters are switched according to the endoscope ID or observation state in the fluorescence mode. The excitation light cut filter shields excitation light generated by the first and second filters.

摘要翻译： 根据本发明的实施例的内窥镜系统包括：内窥镜，具有用于从体腔捕获反射光和荧光的单色图像拾取装置，安装在用于屏蔽激励的图像拾取装置的前方的激发截止滤光器 光和内窥镜ID，其包括关于内窥镜的类型的信息。 光源单元包括照射包括用于荧光图像模式的激发光的光的第一切换滤光器和用于产生用于正常光图像模式的连续光的滤光器。 滤光片基于荧光图像模式和普通光图像模式之间切换。 提供了具有限制第一开关滤波器的某些波长的激发光的限制滤波器的第二开关滤波器。 根据荧光模式中的内窥镜ID或观察状态来切换限制滤光片。 激发光截止滤光器屏蔽由第一和第二滤光器产生的激发光。

公开(公告)号：US20070100207A1

公开(公告)日：2007-05-03

申请号：US11611929

申请日：2006-12-18

申请人： Hitoshi UENO ,  Takeshi OZAWA ,  Kazunari NAKAMURA ,  Isami HIRAO ,  Hiroshi IBE ,  Koichi YOSHIMITSU ,  Yuichi MORIZANE ,  Mamoru KANEKO ,  Shunya AKIMOTO ,  Masaki TERAKUBO ,  Katsuichi IMAIZUMI ,  Nobuyuki DOGUCHI ,  Sakae TAKEHANA ,  Kazuhiro GONO

发明人： Hitoshi UENO ,  Takeshi OZAWA ,  Kazunari NAKAMURA ,  Isami HIRAO ,  Hiroshi IBE ,  Koichi YOSHIMITSU ,  Yuichi MORIZANE ,  Mamoru KANEKO ,  Shunya AKIMOTO ,  Masaki TERAKUBO ,  Katsuichi IMAIZUMI ,  Nobuyuki DOGUCHI ,  Sakae TAKEHANA ,  Kazuhiro GONO

IPC分类号： A61B1/06 ,  A61B6/00

CPC分类号： A61B1/00059 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B5/0071 ,  A61B5/0084

摘要： In the light source unit 3A, a switching filter section 14, which can switch the RGB filter for normal-light observation and a filter for fluorescent observation on the optical path, is installed in front of the lamp 12, where if the fluorescent image mode is selected, the excitation light in a part of the blue wavelength band is supplied to the electronic endoscope 2A, and the excitation light reflected by the subject side is shielded by the excitation light cut filter 27 in front of the CCD 28 so as to obtain the fluorescent image, and also the signal of the fluorescent image and the signals of the two reflected light images which are set in a predetermined wavelength band are passed through the image processing circuit 38, where a matrix circuit for appropriately allocating the color signals of the R, G and B channels is installed, and as a result, the images can be displayed on the monitor 5 in pseudo-colors in hues which allow easy identification of a normal tissue and a pathologically affected tissue.

摘要翻译： 在光源单元3A中，在灯12的前方安装可以切换用于普通光观察的RGB滤光器的开关滤波器部分14和用于荧光观察的滤光器，其中如果荧光图像 选择蓝色波长带的一部分中的激发光被供给到电子内窥镜2A，并且由CCD 28反射的激励光被CCD28前方的激发光截止滤光器27遮蔽，从而 以获得荧光图像，并且将荧光图像的信号和设置在预定波长带中的两个反射光图像的信号通过图像处理电路38，其中用于适当地分配颜色信号的矩阵电路 安装了R，G和B通道，结果，图像可以以色调的伪色显示在监视器5上，这允许容易地识别正常组织和路径 受影响的组织。

公开(公告)号：US06790174B2

公开(公告)日：2004-09-14

申请号：US10045979

申请日：2002-01-10

申请人： Mamoru Kaneko ,  Hitoshi Ueno ,  Sakae Takehana ,  Isami Hirao ,  Nobuyuki Doguchi ,  Takeshi Ozawa ,  Takefumi Uesugi ,  Katsuichi Imaizumi ,  Yasukazu Kogen ,  Makoto Tomioka ,  Tadashi Hirata ,  Masahiro Kawauchi

发明人： Mamoru Kaneko ,  Hitoshi Ueno ,  Sakae Takehana ,  Isami Hirao ,  Nobuyuki Doguchi ,  Takeshi Ozawa ,  Takefumi Uesugi ,  Katsuichi Imaizumi ,  Yasukazu Kogen ,  Makoto Tomioka ,  Tadashi Hirata ,  Masahiro Kawauchi

IPC分类号： A61B1045

CPC分类号： A61B1/045 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  H04N2005/2255

摘要： An imaging system for use with an endoscope, including a light source which emits white light and excitation light which will produce a fluorescence response by an object under inspection, an imaging camera including separate paths for processing images produced by white light and excitation light, a selection device that causes the imaging device to operate in a white light mode or an excitation light mode, and a protective device that prevents damage to high-sensitivity imaging components from exposure to excessive light input. Fluorescent image data are separated into at least red and green color bands which are separately processed to produced a video display in which normal tissue is displayed in predetermined specific color, and abnormal tissue in one or more distinctly different colors. In one embodiment, an image color interpretation guide is provided in the form of multiple color bars which are superimposed on a single video display device with the image display. of different kinds. In another embodiment, color control is provided by adjusting the amplification of the imaging components for each of the color bands while viewing tissue known to be normal using a recursive algorithm until the ratio of the maximum values of the color separation signals fall within a predetermined range. The high-sensitivity imaging components are protected by controlling impingement of light on the imagining components, selectively controlling emission of white and excitation light from the light source, and controlling the power source for the imaging components.

摘要翻译： 一种与内窥镜一起使用的成像系统，包括发出白光的光源和由被检查物体产生荧光响应的激发光，包括用于处理由白光和激发光产生的图像的分离路径的成像摄像机， 选择装置，其使得成像装置在白光模式或激发光模式下操作;以及保护装置，其防止对高灵敏度成像部件的损害暴露于过度的光输入。 荧光图像数据被分成至少红色和绿色色带，其分开处理以产生其中以预定特定颜色显示正常组织的视频显示，以及以一种或多种明显不同的颜色显示异常组织。 在一个实施例中，以多个彩条的形式提供图像颜色解释指南，所述多个彩条叠加在具有图像显示的单个视频显示装置上。 不同种类。 在另一个实施例中，通过调整每个色带的成像部件的放大率来提供颜色控制，同时使用递归算法观察已知为正常的组织，直到颜色分离信号的最大值的比率落在预定范围内 。 高灵敏度成像组件通过控制对想像组件的光的照射来保护，选择性地控制来自光源的白光和激发光的发射，以及控制成像组件的电源。

公开(公告)号：US08542272B2

公开(公告)日：2013-09-24

申请号：US12629394

申请日：2009-12-02

申请人： Shunji Takei ,  Nobuyuki Doguchi ,  Kenji Yamazaki

发明人： Shunji Takei ,  Nobuyuki Doguchi ,  Kenji Yamazaki

IPC分类号： A62B1/04

CPC分类号： A61B1/05 ,  A61B1/00096 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646

摘要： An image generating apparatus according to the present invention includes: a first light source unit that emits light in a first wavelength band to a subject; a second light source unit that emits light in a second wavelength band, which is a part of the first wavelength band, to the subject; an image pickup unit that picks up an image of the subject and outputs the image as an image pickup signal; a light cut filter unit that cuts light in the second wavelength band reflected from the subject; and a complementary processing unit that applies complementary processing to a component equivalent to the second wavelength band cut by the light cut filter unit in the image of the subject picked up by the image pickup unit in a state in which the subject is illuminated by the light in the first wavelength band.

摘要翻译： 根据本发明的图像产生装置包括：第一光源单元，其将第一波长带的光发射到被摄体; 第二光源单元，其将作为第一波长带的一部分的第二波长带的光发射到被摄体; 拾取单元，其拾取被摄体的图像并输出图像作为摄像信号; 切割过滤器单元，其切断从被检体反射的第二波长带的光; 以及互补处理单元，其在被所述被摄体被所述光照射的状态下，对由所述摄像单元拾取的所述被摄体的图像中的由所述遮光滤光器单元切割的所述第二波长带相当的成分进行补充处理 在第一波长带。

公开(公告)号：US07670286B2

公开(公告)日：2010-03-02

申请号：US10869239

申请日：2004-06-16

申请人： Katsuichi Imaizumi ,  Isami Hirao ,  Yoshinori Takahashi ,  Takeshi Ozawa ,  Nobuyuki Doguchi ,  Sakae Takehana

发明人： Katsuichi Imaizumi ,  Isami Hirao ,  Yoshinori Takahashi ,  Takeshi Ozawa ,  Nobuyuki Doguchi ,  Sakae Takehana

IPC分类号： A61B1/06

CPC分类号： A61B1/0638 ,  A61B1/045 ,  A61B1/0646

摘要： The electronic endoscope device in accordance with the present invention comprises an image pick-up unit capable of acquiring an object image with respect to illumination light employed for illuminating the object for each prescribed wavelength band, an exposure period setting circuit for setting the exposure period of the image pick-up unit corresponding to the each wavelength band, an amplification circuit for amplifying picked-up image signals of the object image obtained with the image pick-up unit corresponding to the each wavelength band, and a control circuit for controlling the amplification circuit such that the picked-up image signals corresponded to the each wavelength band of the object image that are acquired with the image pick-up unit at the exposure period set corresponding to the each wavelength band set by the exposure period setting circuit are amplified at amplification factors computed corresponding to the exposure period that is set corresponding to the each wavelength band.

摘要翻译： 根据本发明的电子内窥镜装置包括：摄像单元，其能够获取关于用于照射每个规定波长带的物体的照明光的对象图像;曝光期间设定电路，其设定曝光期间 对应于每个波长带的图像拾取单元，用于放大由与每个波长带对应的图像拾取单元获得的对象图像的拾取图像信号的放大电路，以及用于控制放大的控制电路 电路，使得对应于在与由曝光周期设定电路设定的每个波段相对应设置的曝光周期期间用摄像单元获取的被摄体图像的每个波长带对应的拾取图像信号被放大 对应于对应于每个波纹设置的曝光周期计算的放大因子 整个乐队。

公开(公告)号：US07393321B2

公开(公告)日：2008-07-01

申请号：US10871223

申请日：2004-06-18

申请人： Nobuyuki Doguchi ,  Yoshinori Takahashi ,  Katsuichi Imaizumi ,  Takeshi Ozawa ,  Sakae Takehana ,  Isami Hirao

发明人： Nobuyuki Doguchi ,  Yoshinori Takahashi ,  Katsuichi Imaizumi ,  Takeshi Ozawa ,  Sakae Takehana ,  Isami Hirao

IPC分类号： A61B1/045

CPC分类号： H04N9/07 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B5/0071 ,  A61B5/0084 ,  H04N5/23209 ,  H04N5/2354 ,  H04N2005/2255

摘要： An endoscope apparatus includes an endoscope that has a solid-state image-pickup device in which charges are accumulated in order to pick up an object image. The endoscope apparatus further comprises a memory in which a plurality of pieces of information on the accumulation period during which charges are accumulated in the solid-state image-pickup device is stored, and a drive unit that controls the accumulation period, during which charges are accumulated in the solid-state image-pickup device, on the basis of the pieces of information on the accumulation period stored in the memory. The endoscope further includes an optical member whose surface is shaped rotationally asymmetric. Correction information stored in a memory and associated with the optical element is used to correct an output signal of the solid-state image-pickup device.

摘要翻译： 一种内窥镜装置，具备：具有固体摄像装置的内窥镜，在该内窥镜中积蓄有电荷以便拾取被摄体图像。 内窥镜装置还包括存储有存储固态摄像装置中的电荷累积的累积期间的多条信息的存储器，以及控制蓄电期间的驱动部， 基于存储在存储器中的累积期间的信息来累积在固态图像拾取装置中。 内窥镜还包括光学构件，其表面成形为不对称的。 存储在存储器中并与光学元件相关联的校正信息用于校正固态图像拾取装置的输出信号。

公开(公告)号：US20080021272A1

公开(公告)日：2008-01-24

申请号：US11830619

申请日：2007-07-30

申请人： Nobuyuki Doguchi ,  Yasuo Komatsu ,  Kazunari Nakamura ,  Sakae Takehana ,  Katsuichi Imaizumi ,  Takayuki Hanawa

发明人： Nobuyuki Doguchi ,  Yasuo Komatsu ,  Kazunari Nakamura ,  Sakae Takehana ,  Katsuichi Imaizumi ,  Takayuki Hanawa

IPC分类号： A61B1/04

CPC分类号： H04N7/183 ,  A61B1/00059 ,  A61B1/043 ,  A61B1/045 ,  A61B1/05 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0684 ,  A61B5/0071 ,  A61B5/0084 ,  G02B23/24 ,  G02B23/2469 ,  G02B23/2484 ,  G02B26/008 ,  H04N2005/2255

摘要： An endoscope 2 has a CCD 9 incorporated in the distal part of an insertion unit 6 thereof. The sensitivity of the CCD 9 can be varied by applying a plurality of pulsating driving signals so as to change an electron multiplication rate. The endoscope 2 is connected to a processor 3 so that it can be disconnected freely. Information representing a type of endoscope stored in advance in a ROM 48 is transmitted to a controller 21 incorporated in the processor 3. The control means 21 uses a CCD sensitivity control means 12 to control the sensitivity of the CCD 9 according to the type of connected endoscope 2. Consequently, a view image of proper brightness can be produced irrespective of the type of endoscope 2.

摘要翻译： 内窥镜2具有并入其插入单元6的远端部的CCD 9。 可以通过施加多个脉动驱动信号来改变CCD 9的灵敏度，以改变电子倍增率。 内窥镜2与处理器3连接，能够自由断开。 表示预先存储在ROM48中的内窥镜的信息被传送到内置于处理器3中的控制器21.控制装置21使用CCD敏感度控制装置12根据所连接的类型来控制CCD 9的灵敏度 内窥镜2.因此，无论内窥镜2的种类如何，都可以产生适当亮度的视野图像。

公开(公告)号：US20050117028A1

公开(公告)日：2005-06-02

申请号：US10977654

申请日：2004-10-29

申请人： Katsuichi Imaizumi ,  Isami Hirao ,  Yoshinori Takahashi ,  Takeshi Ozawa ,  Sakae Takehana ,  Nobuyuki Doguchi

发明人： Katsuichi Imaizumi ,  Isami Hirao ,  Yoshinori Takahashi ,  Takeshi Ozawa ,  Sakae Takehana ,  Nobuyuki Doguchi

IPC分类号： A61B1/00 ,  A61B1/04 ,  H04N5/225 ,  H04N5/235 ,  H04N5/335 ,  H04N5/353 ,  H04N5/357 ,  H04N5/372 ,  H04N9/07 ,  H04N5/228

CPC分类号： A61B1/04

摘要： An image pick-up apparatus includes an image pick-up device which picks-up an image of a subject and outputs an image signal, a first-amplitude changing portion which varies an amplitude of the image signal outputted form the image pick-up device, a second-amplitude changing portion which varies the amplitude of the image signal to be outputted, a comparing portion which compares the amplitude of the image signal with a value of a target amplitude, and a control portion which controls the first- and second-amplitude changing portions based on the comparison result of the comparing portion and changes the amplitude of the image signal so that it is approximate to the target amplitude so that an observed image of the subject displayed on display means has a desired brightness.

摘要翻译： 图像拾取装置包括拍摄对象的图像并输出图像信号的图像拾取装置，改变从图像拾取装置输出的图像信号的幅度的第一幅度变化部分 改变要输出的图像信号的幅度的第二幅度变化部分，将图像信号的幅度与目标幅度的值进行比较的比较部分，以及控制第一和第二信号的控制部分， 基于比较部分的比较结果的幅度变化部分，并且改变图像信号的幅度，使得其近似于目标幅度，使得在显示装置上显示的被摄体的观察图像具有期望的亮度。