Semiconductor DNA sensing device and DNA sensing method
    2.
    发明申请
    Semiconductor DNA sensing device and DNA sensing method 审中-公开
    半导体DNA感测装置和DNA感测方法

    公开(公告)号:US20070207471A1

    公开(公告)日:2007-09-06

    申请号:US11514843

    申请日:2006-09-05

    IPC分类号: C12Q1/68 C12M3/00 H01L51/00

    摘要: A semiconductor DNA sensing device having a detection section is provided. The detection section comprises a structure of a probe DNA/a first organic monolayer/an insulating layer/a semiconductor. The field-effect transistor (FET) comprises a semiconductor substrate and a first insulator layer formed thereon as a reactive gate insulator, and the first insulating layer comprises silicon oxide or an inorganic oxide. The first organic monolayer formed on the first insulator layer comprises an organic molecule having a reactive functional group. The probe DNA contains 3 to 35 nucleotides, and this probe DNA is bonded to the first organic monolayer by the reactive functional group either directly or by an intervening crosslinker. The semiconductor DNA sensing device of the present invention is extremely effective as an on-chip, high-sensitivity, micro multi-DNA sensing device, and an integrated device produced by using such semiconductor DNA sensing device is capable of sensing a DNA including a mismatch sequence such as single nucleotide polymorphism, and such device is indispensable for an advanced medicine and personalized medicine.

    摘要翻译: 提供了具有检测部的半导体DNA感测装置。 检测部分包括探针DNA /第一有机单层/绝缘层/半导体的结构。 场效应晶体管(FET)包括半导体衬底和形成在其上的第一绝缘体层作为反应性栅极绝缘体,并且第一绝缘层包括氧化硅或无机氧化物。 形成在第一绝缘体层上的第一有机单层包含具有反应性官能团的有机分子。 探针DNA含有3至35个核苷酸,该探针DNA直接或通过中间交联剂通过反应性官能团与第一有机单层结合。 本发明的半导体DNA感测装置作为片上,高灵敏度的微多DNA感测装置是非常有效的,并且通过使用这种半导体DNA感测装置制造的集成装置能够感测包括不匹配的DNA 序列如单核苷酸多态性,这种装置对先进药物和个性化药物是必不可少的。

    SEMICONDUCTOR DNA SENSING DEVICE AND DNA SENSING METHOD
    4.
    发明申请
    SEMICONDUCTOR DNA SENSING DEVICE AND DNA SENSING METHOD 审中-公开
    半导体DNA感测器件和DNA感测方法

    公开(公告)号:US20100221841A1

    公开(公告)日:2010-09-02

    申请号:US12717074

    申请日:2010-03-03

    IPC分类号: G01N33/50

    摘要: A semiconductor DNA sensing device is provided herein, which includes a detection section with a field-effect transistor including a semiconductor substrate and a first insulator layer formed thereon as a reactive gate insulator, the first insulating layer including silicon oxide or an inorganic oxide, a first organic monolayer formed on the first insulator layer, the first organic monolayer comprising an organic molecule having a reactive functional group, and a probe DNA containing 3 to 35 nucleotides bonded to the first organic monolayer by the reactive functional group either directly or by an intervening crosslinker, the structure of the probe DNA/the first organic monolayer/the insulating layer/the semiconductor constituting the detection section.

    摘要翻译: 本文提供了一种半导体DNA感测装置,其包括具有场效应晶体管的检测部分,该场效应晶体管包括半导体衬底和形成在其上的作为反应栅极绝缘体的第一绝缘体层,所述第一绝缘层包括氧化硅或无机氧化物, 形成在第一绝缘体层上的第一有机单层,包含具有反应性官能团的有机分子的第一有机单层和通过反应性官能团与第一有机单层结合的3至35个核苷酸的探针DNA直接或通过介入 交联剂,探针DNA /第一有机单层/构成检测部分的绝缘层/半导体的结构。