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公开(公告)号:US20130210743A1
公开(公告)日:2013-08-15
申请号:US13816880
申请日:2011-08-13
IPC分类号: C07K7/64
CPC分类号: C07K7/64 , A61K38/00 , C07K7/56 , C07K14/4746
摘要: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
摘要翻译: 本发明提供新颖的拟肽大环化合物和使用这种大环化合物治疗疾病的方法。
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公开(公告)号:US08399405B2
公开(公告)日:2013-03-19
申请号:US13366113
申请日:2012-02-03
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
CPC分类号: G01N33/5008 , C07K14/00 , C07K14/4705 , C07K14/4747 , C07K14/4748 , G01N2500/10
摘要: Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides; and methods of making and identifying such improved polypeptides.
摘要翻译: 具有相对于其对应的前体多肽具有改进性质的生物活性交联多肽; 以及制备和鉴定这些改良多肽的方法。
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公开(公告)号:US20100298201A1
公开(公告)日:2010-11-25
申请号:US12625533
申请日:2009-11-24
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
IPC分类号: A61K38/17 , C07K14/435 , A61P35/00 , A61P19/02 , A61P11/06 , A61P3/10 , A61P25/00 , A61P9/00 , A61P5/00
CPC分类号: G01N33/68 , A61K31/02 , C07K2/00 , C07K14/001 , C07K14/4705 , C07K14/4747 , C07K14/4748
摘要: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
摘要翻译: 本发明提供了相对于其相应多肽具有改进性质的生物活性的拟肽大环化合物。 本发明另外提供了制备和使用这种大环化合物的方法,例如在治疗应用中。
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公开(公告)号:US08859723B2
公开(公告)日:2014-10-14
申请号:US13816880
申请日:2011-08-13
IPC分类号: A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/00 , A61P35/00 , C07K7/64 , C07K7/56
CPC分类号: C07K7/64 , A61K38/00 , C07K7/56 , C07K14/4746
摘要: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
摘要翻译: 本发明提供新颖的拟肽大环化合物和使用这种大环化合物治疗疾病的方法。
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公开(公告)号:US20120264674A1
公开(公告)日:2012-10-18
申请号:US13350644
申请日:2012-01-13
摘要: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
摘要翻译: 本发明涉及纯化的拟肽大环化合物。 本发明另外提供了制备和使用这种大环化合物的方法,例如在治疗应用中。
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公开(公告)号:US20120149648A1
公开(公告)日:2012-06-14
申请号:US13352223
申请日:2012-01-17
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
CPC分类号: C07K7/64 , A61K38/12 , A61K38/1761 , A61K45/06
摘要: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
摘要翻译: 本发明提供用于治疗细胞增殖性疾病如癌症和免疫增殖性疾病的生物活性的拟肽大环化合物。
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公开(公告)号:US09394336B2
公开(公告)日:2016-07-19
申请号:US13350644
申请日:2012-01-13
摘要: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
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公开(公告)号:US09206223B2
公开(公告)日:2015-12-08
申请号:US12564909
申请日:2009-09-22
摘要: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
摘要翻译: 本发明涉及纯化的拟肽大环化合物。 本发明另外提供了制备和使用这种大环化合物的方法,例如在治疗应用中。
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公开(公告)号:US08524653B2
公开(公告)日:2013-09-03
申请号:US12564910
申请日:2009-09-22
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Llbermann , Tomi K. Sawyer , Noriyuki Kawahata
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Llbermann , Tomi K. Sawyer , Noriyuki Kawahata
CPC分类号: G01N33/5008 , C07K14/00 , C07K14/4705 , C07K14/4747 , C07K14/4748 , G01N2500/10
摘要: Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins, and methods of identifying and making such improved polypeptides are described.
摘要翻译: 描述了具有相对于其对应的前体多肽具有良好的细胞穿透性质和降低的与人蛋白质的结合的改进性质的生物活性交联多肽,以及鉴定和制备这种改良的多肽的方法。
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公开(公告)号:US20120172311A1
公开(公告)日:2012-07-05
申请号:US13366113
申请日:2012-02-03
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
CPC分类号: G01N33/5008 , C07K14/00 , C07K14/4705 , C07K14/4747 , C07K14/4748 , G01N2500/10
摘要: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
摘要翻译: 本发明提供具有相对于其相应的前体多肽具有改善的性质的生物活性交联多肽,具有良好的细胞穿透性质和降低与人蛋白质的结合。 本发明另外提供鉴定和制备这种改良多肽的方法。
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