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公开(公告)号:US20210214458A1
公开(公告)日:2021-07-15
申请号:US17055248
申请日:2019-05-13
发明人: Yang Liu , Pan Zheng , Rhonda Flores , Hung-Yen Chou , Zhihong Xue , Peiying Ye , Martin Devenport
摘要: Provided herein are anti-CD24 antibodies that selectively bind human CD24 expressed in cancer cells, but not human CD24 expressed in non-cancerous cells, and the use of such antibodies in cancer therapy.
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公开(公告)号:US20210161991A1
公开(公告)日:2021-06-03
申请号:US17069300
申请日:2020-10-13
申请人: OncoImmune, Inc.
发明人: Yang LIU , Yin WANG , Yan LIU , Sami N. MALEK , Pan ZHENG
IPC分类号: A61K38/07 , A61K31/395 , A61K31/498 , A61K31/565 , A61K45/06 , A61K31/00 , A61K31/4355
摘要: The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
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3.
公开(公告)号:US20210046154A1
公开(公告)日:2021-02-18
申请号:US16977628
申请日:2019-03-05
申请人: ONCOIMMUNE, INC. , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , INSTITUTE OF BIOPHYSICS, CHINESE ACADEMY OF SCIENCES , KUNMING INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES
发明人: Yang Liu , Pan Zhang , Lishan Su , Yong-Tang Zheng , Liguo Zhang
摘要: The present invention relates to a method of treating, mitigating, minimizing, or preventing HIV-1/AIDS by administering a CD24 protein to a subject in need thereof. Also provided herein is use of a CD24 protein in the manufacture of a medicament for treating HIV-1/AIDS. Further, provided is a pharmaceutical composition comprising a pharmaceutically acceptable amount of a CD24 protein.
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公开(公告)号:US20190263889A1
公开(公告)日:2019-08-29
申请号:US16333888
申请日:2017-09-19
发明人: Yang LIU , Pan ZHENG , Martin DEVENPORT , Wei WU , Xuexiang DU , Mingyue LIU , Fei TANG
IPC分类号: C07K14/705 , C07K16/28 , A61P35/00 , A61P37/06
摘要: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.
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5.
公开(公告)号:US20210228680A1
公开(公告)日:2021-07-29
申请号:US15734961
申请日:2019-06-03
申请人: ONCOIMMUNE, INC.
发明人: Yang Liu , Pan Zheng , Martin Devenport
摘要: The present invention relates to the use of a CD24 protein for preventing or treating Graft versus Host Disease and mucositis.
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公开(公告)号:US20200147167A1
公开(公告)日:2020-05-14
申请号:US16748455
申请日:2020-01-21
申请人: OncoImmune, Inc.
发明人: Yang LIU , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
IPC分类号: A61K38/07 , A61K31/4355 , A61K38/08 , A61K31/00 , A61K45/06 , A61K31/565 , A61K31/498 , A61K31/395
摘要: The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
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公开(公告)号:US20190255140A1
公开(公告)日:2019-08-22
申请号:US16294615
申请日:2019-03-06
申请人: OncoImmune, Inc.
发明人: Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
IPC分类号: A61K38/07 , A61K38/08 , A61K31/4355 , A61K31/00 , A61K31/395 , A61K31/565 , A61K31/498 , A61K45/06
摘要: The present invention relates to treating, a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIT inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIE inhibitor.
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公开(公告)号:US20190038716A1
公开(公告)日:2019-02-07
申请号:US16074726
申请日:2017-02-02
申请人: ONCOIMMUNE, INC.
发明人: Yang LIU , Pan ZHENG , Martin DEVENPORT
摘要: This invention relates to the use of a CD24 protein for treating leptin-deficient conditions, such as lipodystrophy, by increasing the level of circulating leptin.
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公开(公告)号:US09611309B2
公开(公告)日:2017-04-04
申请号:US14519745
申请日:2014-10-21
申请人: OncoImmune, Inc.
发明人: Xincheng Zheng , Wei Wu , Yang Liu , Pan Zheng
IPC分类号: C07K19/00 , C07K14/705 , C07K14/435 , C07K14/47
CPC分类号: C07K14/70596 , C07K14/435 , C07K14/47 , C07K19/00 , C07K2319/30
摘要: Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian immunoglobulin.
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公开(公告)号:US20220125874A1
公开(公告)日:2022-04-28
申请号:US16491708
申请日:2018-03-06
申请人: ONCOIMMUNE, INC.
发明人: Yang LIU , Pan ZHENG , Martin DEVENPORT
摘要: The present invention relates to the use of a CD24 protein for treating Systemic Lupus Erythematosus (Lupus, SLE).
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