公开(公告)号：US20070072240A1

公开(公告)日：2007-03-29

申请号：US11522978

申请日：2006-09-19

申请人： Ole Brekke ,  John Stacy ,  Louise Kausmally

发明人： Ole Brekke ,  John Stacy ,  Louise Kausmally

IPC分类号： C40B30/06 ,  C40B40/10 ,  G01N33/53 ,  A61K39/00

CPC分类号： C12Q1/6809 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/088 ,  C07K16/1217 ,  C07K2317/21 ,  C07K2317/622

摘要： The present invention relates to an antibody expression library derived from a patient which has been immunochallenged with one or more foreign antigens associated with a particular disease or foreign agent, wherein said patients have been immunochallenged with the foreign antigens at a time point such that they still contain a repertoire of antibody producing cells which are enriched with cells producing antibodies directed to said foreign antigens associated with said disease or foreign agent, or at a time point such that they are still in an active phase of immune response to said foreign antigens associated with said disease or foreign agent. Methods of producing such expression libraries are also disclosed.

摘要翻译： 本发明涉及来自患者的抗体表达文献，所述抗体表达文库已被一种或多种与特定疾病或外来试剂相关联的外来抗原免疫突变，其中所述患者在时间点已经与外来抗原免疫激活， 含有抗体产生细胞的所有组成成分，所述细胞富含细胞，所述细胞产生针对与所述疾病或异种细胞相关的所述外源抗原的抗体，或者在时间点，使得它们仍然处于与所述外源抗原相关的所述外来抗原的免疫应答的活性期 说疾病或外来药物。 还公开了产生这种表达文库的方法。