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公开(公告)号:US09573928B2
公开(公告)日:2017-02-21
申请号:US14502112
申请日:2014-09-30
申请人: Olivier Loiseleur , Daniel Kaufmann , Stephan Abel , Hans Michael Bürger , Mark Meisenbach , Beat Schmitz , Gottfried Sedelmeier
发明人: Olivier Loiseleur , Daniel Kaufmann , Stephan Abel , Hans Michael Bürger , Mark Meisenbach , Beat Schmitz , Gottfried Sedelmeier
IPC分类号: C07D401/14 , C07D401/04 , C07D295/155
CPC分类号: C07D401/04 , C07D295/155 , C07D401/14
摘要: The present invention relates to novel amides and a process for preparing these amides.
摘要翻译: 本发明涉及新颖的酰胺和这些酰胺的制备方法。
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公开(公告)号:US20110301031A1
公开(公告)日:2011-12-08
申请号:US13133754
申请日:2009-12-09
申请人: Michel Muehlebach , Thomas Pitterna , Jérôme Yves Cassayre , Andrew Edmunds , Camilla Corsi , Myriem El Qacemi , Roger Graham Hall , André Jeanguenat , André Stoller , Christopher Richard Ayles Godfrey , Jürgen Harry Schaetzer , Olivier Loiseleur , Peter Maienfisch , Neil Brian Carter
发明人: Michel Muehlebach , Thomas Pitterna , Jérôme Yves Cassayre , Andrew Edmunds , Camilla Corsi , Myriem El Qacemi , Roger Graham Hall , André Jeanguenat , André Stoller , Christopher Richard Ayles Godfrey , Jürgen Harry Schaetzer , Olivier Loiseleur , Peter Maienfisch , Neil Brian Carter
IPC分类号: A01N25/32 , C07D211/32 , A61K31/438 , A61K31/445 , A01N43/40 , A01P3/00 , A01P13/00 , A01P1/00 , A01P9/00 , A01P7/04 , A01P5/00 , C07D471/10 , A01N57/00
CPC分类号: C07D471/10 , A01N43/90 , A01N47/06 , C07D211/94 , C07D405/12
摘要: A compound of the formula (I), wherein the substituents are as defined in claim 1, are useful as a pesticides.
摘要翻译: 式(I)的化合物,其中取代基如权利要求1中所定义,可用作农药。
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公开(公告)号:US07812170B2
公开(公告)日:2010-10-12
申请号:US10598041
申请日:2005-03-02
申请人: David John Hughes , James Edward Peace , Suzanna Riley , Sally Russell , Joseph John Swanborough , Roger Graham Hall , André Jeanguenat , Olivier Loiseleur , Peter Renold , Stephan Trah , Jean Wenger
发明人: David John Hughes , James Edward Peace , Suzanna Riley , Sally Russell , Joseph John Swanborough , Roger Graham Hall , André Jeanguenat , Olivier Loiseleur , Peter Renold , Stephan Trah , Jean Wenger
IPC分类号: C07D401/00
CPC分类号: C07D401/04 , A01N37/46 , A01N43/40 , A01N43/56 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D493/08 , C07D495/04 , C07D513/04
摘要: Compounds of the formula (I) in which Z, is an oxygen atom; or a sulfur atom; Z2 is an oxygen atom; or a sulfur atom; R, is an aryl or heteroaryl group, which is unsubstituted or substituted; R2 is hydrogen; or an organic substituent; R3 is hydrogen; or an organic substituent; R4 is hydrogen; or an organic substituent; or R3 and R4, taken together, form, together with the nitrogen atom, to which they are attached, a ring, which is unsubstituted or substituted; R5 is hydrogen; or an unsubstituted or substituted alkyl group; or forms, taken together with R8 or with a monovalent substituent attached to that atom of R6, via which atom R6 is directly connected with the carbon atom, shown in the formula I, which carries R5, one additional bond; R6 and R7, taken together, form, together with the two carbon atoms, shown in the formula I, to which atoms they are attached, a bicyclic ring system, which ring system is carbocyclic or heterocyclic, which ring system is substituted, in the manner shown in the formula I, by the four substituents —N(R2)-C(═Z1)-R, —C(═Z2)-N(R3)-R4, R5 and R8, and which ring system is optionally further substituted; and R8 is hydrogen; or an unsubstituted or substituted alkyl group; or forms, taken together with R5 or with a monovalent substituent attached to that atom of R7, via which atom R7 is directly connected with the carbon atom, shown in the formula I, which carries R8, one additional bond, and, where appropriate, tautomers thereof, in each case in free form or in salt form, can be used as agrochemical active ingredients and can be prepared in a manner known per se.
摘要翻译: 其中Z为氧原子的式(I)化合物; 或硫原子; Z2是氧原子; 或硫原子; R 1是未取代或取代的芳基或杂芳基; R2是氢; 或有机取代基; R3是氢; 或有机取代基; R4是氢; 或有机取代基; 或者R 3和R 4一起与它们所连接的氮原子一起形成未被取代或被取代的环, R5是氢; 或未取代或取代的烷基; 或其形式,与R8一起或与R6的该原子连接的一价取代基,其中原子R6直接与碳原子连接,如式I所示,其携带R5,另外一个键; R6和R7一起与式I中所示的两个碳原子一起形成,其中它们连接的原子是双环系统,该环系是碳环或杂环的,该环系被取代,在 式(I)所示的四种取代基-N(R 2)-C(= Z 1)-R,-C(= Z 2)-N(R 3)-R 4,R 5和R 8, 取代 R8是氢; 或未取代或取代的烷基; 或其形式与R5一起或与R7的原子连接的一价取代基,其中原子R7与碳原子直接连接,如式I所示,其携带R8,一个附加键,并且在适当的情况下, 互变异构体,以游离形式或盐形式,可以用作农业化学活性成分,并且可以以本身已知的方式制备。
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公开(公告)号:US20100273830A1
公开(公告)日:2010-10-28
申请号:US12668939
申请日:2008-07-14
申请人: Roger Graham Hall , Olivier Loiseleur , Jagadish Pabba , Sitaram Pal , Andre Jeanguenat , Andrew Edmunds , Andre Stoller
发明人: Roger Graham Hall , Olivier Loiseleur , Jagadish Pabba , Sitaram Pal , Andre Jeanguenat , Andrew Edmunds , Andre Stoller
IPC分类号: A01N43/78 , C07D493/04 , C07D487/04 , C07D498/04 , C07D513/04 , A01N43/76 , A01N43/52 , A01N43/58 , A01N43/56 , C07D495/04 , C07D401/04 , A01P7/02 , A01P7/04
CPC分类号: C07D317/68 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D411/14 , C07D413/14 , C07D417/14 , C07D498/12
摘要: An insecticidal compound of formula (I) in which G1, G2, and G3 together with the two carbon atoms to which G1 and G3 are attached, form a non-aromatic 4- or 5-membered ring system; wherein G1 is sulfur, SO, SO2, oxygen, a direct bond, NRa or CR5aR5b; G2 is sulfur, SO, SO2, oxygen, a direct bond, NRb or CR5cR5d; G3 is sulfur, SO, SO2, oxygen, a direct bond, NRc or CR5eR5f; with the provisos that a) not more than 1 group G can be a direct bond, b) not more than 2 G groups can be oxygen, sulfur, SO or SO2 and c) when 2 G groups are oxygen, SO, SO2 and/or sulfur the two groups are separated by a carbon atom; each of Z1 and Z2, which may be the same or different, represents oxygen or sulfur; D is phenyl or a 5- or 6-membered heteroaromatic ring and R1a, R1b, R5a, R5b, R5c, R5d, R5e, R5f, Ra, Rb Rc, R2, R3 and R20 are specified organic groups and agronomically acceptable salts/isomers/enantiomers/tautomers/N-oxides of those compounds.
摘要翻译: 其中G1,G2和G3与G1和G3所连接的两个碳原子连接的式(I)杀虫化合物形成非芳族4-或5-元环系; 其中G1是硫,SO,SO2,氧,直接键,NRa或CR5aR5b; G2是硫,SO,SO2,氧,直接键,NRb或CR5cR5d; G3是硫,SO,SO2,氧,直接键,NRc或CR5eR5f; 条件是a)不超过1组G可以是直接键,b)不超过2G基团可以是氧,硫,SO或SO 2,以及c)当2G基团是氧,SO,SO 2和/ 或硫,两个基团被碳原子隔开; Z1和Z2中的每一个可以相同或不同,表示氧或硫; D是苯基或5-或6-元杂芳环,R1a,R1b,R5a,R5b,R5c,R5d,R5e,R5f,Ra,RbRc,R2,R3和R20是指定的有机基团和农艺学上可接受的盐/异构体 /对映异构体/互变异构体/ N-氧化物。
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公开(公告)号:US20080275065A1
公开(公告)日:2008-11-06
申请号:US11576950
申请日:2005-10-10
申请人: Anthony Cornelius O'Sullivan , David John Hughes , Andre Jeanguenat , Michel Muehlebach , Olivier Loiseleur
发明人: Anthony Cornelius O'Sullivan , David John Hughes , Andre Jeanguenat , Michel Muehlebach , Olivier Loiseleur
IPC分类号: A01N43/40 , C07D401/04 , A01N43/54 , A01P7/04 , C07D487/04
CPC分类号: C07D405/14 , A01N43/56 , C07D401/04 , C07D409/14
摘要: Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as agrochemical active ingredients and can be prepared in a manner known per se.
摘要翻译: 其中取代基如权利要求1所定义的式I化合物,以及式I化合物的农业化学上可接受的盐和所有立体异构体和互变异构形式可以用作农业化学活性成分,并且可以以本身已知的方式制备。
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公开(公告)号:US20080249318A1
公开(公告)日:2008-10-09
申请号:US11893481
申请日:2007-08-16
申请人: Murat Acemoglu , Thomas Allmendinger , John Vincent Calienni , Jacques Cercus , Olivier Loiseleur , Gottfried Sedelmeier , David Xu
发明人: Murat Acemoglu , Thomas Allmendinger , John Vincent Calienni , Jacques Cercus , Olivier Loiseleur , Gottfried Sedelmeier , David Xu
IPC分类号: C07D209/34 , C07C227/22 , C07C211/55 , C07C233/01
CPC分类号: C07C211/52 , C07C211/56 , C07C227/22 , C07C229/42 , C07C233/15 , C07C235/16 , C07C235/24 , C07C2601/16 , C07D209/34
摘要: A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.
摘要翻译: 制备式I化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法,其包括用碱定义其中符号如本文所定义的式II的内酰胺; 及其前体和制备前体的方法。 式I的化合物是作为环加氧酶II的选择性抑制剂的药物活性化合物。
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公开(公告)号:US20070293683A1
公开(公告)日:2007-12-20
申请号:US11845946
申请日:2007-08-28
申请人: Olivier Loiseleur , Daniel Kaufmann , Stephan Abel , Hans Burger , Mark Meisenbach , Beat Schmitz , Gottfried Sedelmeier
发明人: Olivier Loiseleur , Daniel Kaufmann , Stephan Abel , Hans Burger , Mark Meisenbach , Beat Schmitz , Gottfried Sedelmeier
IPC分类号: C07D211/70
CPC分类号: C07D401/04 , C07D295/155 , C07D401/14
摘要: The present invention relates to novel amides and a process for preparing these amides.
摘要翻译: 本发明涉及新颖的酰胺和这些酰胺的制备方法。
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公开(公告)号:US20060063820A1
公开(公告)日:2006-03-23
申请号:US10540038
申请日:2003-12-22
申请人: Peter Renold , Werner Zambach , Arthur Steiger , Roger Hall , Olivier Loiseleur , Stephan Trah
发明人: Peter Renold , Werner Zambach , Arthur Steiger , Roger Hall , Olivier Loiseleur , Stephan Trah
CPC分类号: C07C255/54 , A01N31/08 , A01N31/16 , A01N33/20 , A01N37/38 , A01N37/40 , A01N43/28 , A01N43/30 , A01N43/40 , A01N43/42 , A01N43/56 , A01N47/30 , A01N53/00 , C07C43/225 , C07C43/29 , C07C49/84 , C07C69/708 , C07C69/712 , C07C69/743 , C07C69/76 , C07C69/92 , C07C205/34 , C07C205/37 , C07C205/43 , C07C205/49 , C07C205/56 , C07C205/57 , C07C235/16 , C07C255/55 , C07C255/57 , C07C271/16 , C07C271/48 , C07C275/30 , C07C275/34 , C07C2601/02 , C07D213/63 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D215/20 , C07D215/233 , C07D215/58 , C07D231/20 , C07D231/22 , C07D233/94 , C07D257/04 , C07D277/34 , C07D285/08 , C07D285/14 , C07D307/58 , C07D317/64 , C07D333/32
摘要: Compounds of formula (I), wherein A1 is, for example, a bond or a C1-C6alkylene bridge; A2 is, for example, a bond or C1-C6alkylene; A3 is, for example, C1-C6alkylene; W is, for example, O or S; T is, for example, a bond, O, NH, NR7, S, SO, SO2, —C(═O)—O— or —O—C(═O)—; Q is a bond, O, NR7, S, SO or SO2; Y is O, NR7, S, SO or SO2; X1 and X2 are, each independently of the other, fluorine, chlorine, bromine or iodine; R1 is, for example, halogen, CN, nitro, C1-C6alkyl or C1-C6haloalkyl; R2 and R3 are, for example, H, halogen, CN, nitro or C1-C6alkyl; R7 is, for example, H, C1-C6alkyl or C1-C3haloalkyl; m is 1 or 2; and E is C1-C6alkyl, C1-C6haloalkyl, aryl or heterocyclyl; and, where applicable, possible E/Z isomers, mixtures of E/Z isomers and/or tautomers thereof, in each case in free form or in salt form; a process for the preparation of and the use of those compounds; pesticidal compositions in which the active ingredient has been selected from those compounds, or an agrochemically usable salt thereof; a process for the preparation of and the use of those compositions; plant propagation material treated with those compositions; and a method of controlling pests are described.
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公开(公告)号:US20110224079A1
公开(公告)日:2011-09-15
申请号:US13130721
申请日:2009-11-30
申请人: Michel Muehlebach , Thomas Pitterna , Andre Jeanguenat , Myriem El Qacemi , Roger Graham Hall , Andrew Edmunds , Camilla Corsi , Andre Stoller , Christopher Richard Godfrey , Jurgen Harry Schaetzer , Olivier Loiseleur , Peter Maienfisch , Jerome Yves Cassayre
发明人: Michel Muehlebach , Thomas Pitterna , Andre Jeanguenat , Myriem El Qacemi , Roger Graham Hall , Andrew Edmunds , Camilla Corsi , Andre Stoller , Christopher Richard Godfrey , Jurgen Harry Schaetzer , Olivier Loiseleur , Peter Maienfisch , Jerome Yves Cassayre
IPC分类号: A01N25/32 , A01N43/40 , C07D471/10 , C07D211/98 , C07D405/12 , C07D211/56 , C07D409/12 , C07D401/12 , A01P3/00 , A01P13/00 , A01P15/00 , A01P21/00
CPC分类号: C07D471/10 , A01N43/90 , A01N47/06 , C07D211/94
摘要: Novel compounds of the formula (I), wherein the substituents are as defined in claim 1; compositions containing them and their use as insecticides, acaricides, nematicides or molluscicides.
摘要翻译: 新的式(I)化合物,其中取代基如权利要求1所定义; 含有它们的组合物及其作为杀虫剂,杀螨剂,杀线虫剂或杀软体动物剂的用途。
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公开(公告)号:US07906677B2
公开(公告)日:2011-03-15
申请号:US12436991
申请日:2009-05-07
申请人: Murat Acemoglu , Thomas Allmendinger , John Vincent Calienni , Jacques Cercus , Olivier Loiseleur , Gottfried Sedelmeier , David Xu
发明人: Murat Acemoglu , Thomas Allmendinger , John Vincent Calienni , Jacques Cercus , Olivier Loiseleur , Gottfried Sedelmeier , David Xu
IPC分类号: C07C227/22 , C07C209/62
CPC分类号: C07C211/52 , C07C211/56 , C07C227/22 , C07C229/42 , C07C233/15 , C07C235/16 , C07C235/24 , C07C2601/16 , C07D209/34
摘要: A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.
摘要翻译: 制备式I化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法,其包括用碱定义其中符号如本文所定义的式II的内酰胺; 及其前体和制备前体的方法。 式I的化合物是作为环加氧酶II的选择性抑制剂的药物活性化合物。
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