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128 条记录 (耗时 0.043 秒)

    Piperidine sulphonamide derivatives
    3.
    发明授权
    Piperidine sulphonamide derivatives 有权
    哌啶磺酰胺衍生物

    公开(公告)号：US08202888B2

    公开(公告)日：2012-06-19

    申请号：US12365911

    申请日：2009-02-05

    申请人： Henner Knust ,  Matthias Nettekoven ,  Emmanuel Pinard ,  Olivier Roche ,  Mark Rogers-Evans

    发明人： Henner Knust ,  Matthias Nettekoven ,  Emmanuel Pinard ,  Olivier Roche ,  Mark Rogers-Evans

    IPC分类号： A61K31/454 ,  C07D401/06

    CPC分类号： C07D401/06 ,  C07D211/96

    摘要： The present invention relates to piperidine sulphonamide derivatives of formula wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid addition salts thereof. The compounds of formula I are orexin receptor antagonists and the related compounds can be useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.

    摘要翻译： 本发明涉及下式的哌啶磺酰胺衍生物其中Ar 1，Ar 2，R 1，R 2，m和n如说明书和权利要求中所定义，或其药学上合适的酸加成盐。 式I化合物是食欲蛋白受体拮抗剂，相关化合物可用于治疗睡眠呼吸暂停，发作性睡病，失眠，睡眠，夜间综合征，昼夜节律障碍或与神经疾病相关的睡眠障碍。

    5-substituted benzoxazines
    5.
    发明授权
    5-substituted benzoxazines 失效
    5-取代的苯并恶嗪

    公开(公告)号：US08044047B2

    公开(公告)日：2011-10-25

    申请号：US12549687

    申请日：2009-08-28

    申请人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： C07D265/02 ,  C07D413/04 ,  A61K31/536

    CPC分类号： C07D265/18

    摘要： The present invention is concerned with 5-substituted benzoxazine derivatives of formula (I) wherein X, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions containing them. Compounds of the present invention are 5-HT5A receptor antagonists, and are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及式（I）的5-取代苯并恶嗪衍生物，其中X，R 1和R 2如本文所述，以及它们的制备，含有它们的药物组合物。 本发明化合物是5-HT5A受体拮抗剂，可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐惧症，社交恐惧症，强迫症，创伤后应激障碍，疼痛， 记忆障碍，痴呆，饮食行为障碍，性功能障碍，睡眠障碍，滥用药物，运动障碍如帕金森病，精神病或胃肠疾病。

    2-aminoquinoline derivatives
    8.
    发明授权
    2-aminoquinoline derivatives 失效
    2-氨基喹啉衍生物

    公开(公告)号：US07994324B2

    公开(公告)日：2011-08-09

    申请号：US12394092

    申请日：2009-02-27

    申请人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： C07D215/38

    CPC分类号： C07D215/38 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

    摘要： The present invention is concerned with 2-aminoquinoline derivatives, in particular compounds of formula (I) wherein R1 and R2 are as described herein, pharmaceutical compositions containing such compounds, and methods for their manufacture. The compounds of the invention are 5-HT5A receptor antagonists useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及2-氨基喹啉衍生物，特别是式（I）的化合物，其中R 1和R 2如本文所述，含有这些化合物的药物组合物及其制备方法。 本发明的化合物是可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐怖症，社会恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍， 痴呆症，饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神疾病或胃肠疾病。

    2-aminoquinolines
    9.
    发明授权
    2-aminoquinolines 失效
    2-氨基喹啉

    公开(公告)号：US07989628B2

    公开(公告)日：2011-08-02

    申请号：US12394083

    申请日：2009-02-27

    申请人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： C07D215/38

    CPC分类号： C07D215/38 ,  C07D405/12

    摘要： The present invention is concerned with 2-aminoquinoline derivatives of formula I wherein Z, R1, and Ar1 are as defined herein, pharmaceutical compositions containing them, methods for their manufacture. The compounds are 5-HT5A receptor antagonists and are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及式I的2-氨基喹啉衍生物，其中Z，R 1和Ar 1如本文所定义，含有它们的药物组合物，其制备方法。 这些化合物是5-HT5A受体拮抗剂，可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐怖症，社交恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆 饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神病或胃肠疾病。